Aged xCT-Deficient Mice Are Less Susceptible for Lactacystin-, but Not 1-Methyl-4-Phenyl-1,2,3,6- Tetrahydropyridine-, Induced Degeneration of the Nigrostriatal Pathway

Autor: Eduard Bentea, Laura De Pauw, Lise Verbruggen, Lila C. Winfrey, Lauren Deneyer, Cynthia Moore, Giulia Albertini, Hideyo Sato, Ann Van Eeckhaut, Charles K. Meshul, Ann Massie

Publikováno v: Frontiers in Cellular Neuroscience, Vol 15 (2021)

The astrocytic cystine/glutamate antiporter system xc– (with xCT as the specific subunit) imports cystine in exchange for glutamate and has been shown to interact with multiple pathways in the brain that are dysregulated in age-related neurological

Externí odkaz: https://doaj.org/article/a6d327e1e24344a8926ec84d90535739

Ketamine Does Not Exert Protective Properties on Dopaminergic Neurons in the Lactacystin Mouse Model of Parkinson’s Disease

Autor: Lauren Deneyer, Ann Massie, Eduard Bentea

Publikováno v: Frontiers in Behavioral Neuroscience, Vol 12 (2018)

Parkinson’s disease (PD) is an age-related neurodegenerative condition characterized by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). A loss of proteasome function participates to the pathogenesis of PD, l

Externí odkaz: https://doaj.org/article/aeb766347d434ef2a7cf40415c3e9cc1

CHronic RhINOSinusitis Outcome Registry (CHRINOSOR): establishment of an international outcome registry driven by mHealth technology

Autor: Sven F. Seys, Peter W. Hellings, Isam Alobid, Vibeke Backer, Emilie Bequignon, Christian von Buchwald, Carlo Cavaliere, André Coste, Lauren Deneyer, Zuzana Diamant, Julia Eckl-Dorna, Wytske J. Fokkens, Simon Gane, Philippe Gevaert, Christiane Holbaek-Haase, Clemens Holzmeister, Claire Hopkins, Valérie Hox, Caroline Huart, Roger Jankowski, Mark Jorissen, Anette Kjeldsen, Lisa Knipps, Bibi Lange, Rik van der Lans, Anu Laulajainen-Hongisto, Kenneth Larsen, David T. Liu, Valerie Lund, Gert Mariën, Simonetta Masieri, Geoffrey Mortuaire, Joaquim Mullol, Sietze Reitsma, Philippe Rombaux, Sven Schneider, Andreas Steinsvik, Peter-Valentin Tomazic, Sanna K. Toppila-Salmi, Laura Van Gerven, Thibaut Van Zele, Paula Virkkula, Martin Wagenmann, Claus Bachert

Publikováno v: The Journal of Allergy and Clinical Immunology: In Practice, Vol. 11, no.2, p. 431 (2022)

Real-world evidence (RWE) is a valuable instrument to better understand the patient journey and effectiveness of therapies. RWE on prevalence of uncontrolled CRS and CRS natural course of disease across Europe is scarce. In addition, there is limited

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12bd2c4204b5ea04f265995685d2e748
https://pubmed.ncbi.nlm.nih.gov/36272718

Chronic sulfasalazine treatment in mice induces system xc- - independent adverse effects

Autor: Lindsay Sprimont, Lauren Deneyer, Pauline Janssen, Olaya Lara, Azzedine Gharib, Ann Massie, Charles Nicaise, Hideyo Sato, Lise Verbruggen, Eduard Bentea, Laura De Pauw

Publikováno v: Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 12 (2021)
Verbruggen, L, Sprimont, L, Bentea, E, Janssen, P, Gharib, A, Deneyer, L, De Pauw, L, Lara, O, Sato, H, Nicaise, C & Massie, A 2021, ' Chronic sulfasalazine treatment in mice induces system xc--independent adverse effects ', Frontiers in Pharmacology, vol. 12, 625699 . https://doi.org/10.3389/fphar.2021.625699

Despite ample evidence for the therapeutic potential of inhibition of the cystine/glutamate antiporter system xc− in neurological disorders and in cancer, none of the proposed inhibitors is selective. In this context, a lot of research has been per

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::039ae793fd2926f0f04f5aed25a5b034
https://doi.org/10.3389/fphar.2021.625699

Plastic changes at corticostriatal synapses predict improved motor function in a partial lesion model of Parkinson’s disease

Autor: Charles K. Meshul, Lise Verbruggen, Eduard Bentea, Madeline J Churchill, Lauren Deneyer, Rebecca L. Hood, Ann Massie, Cynthia Moore

Publikováno v: Brain Research Bulletin. 130:257-267

In Parkinson's disease, striatal dopamine depletion leads to plastic changes at excitatory corticostriatal and thalamostriatal synapses. The functional consequences of these responses on the expression of behavioral deficits are incompletely understo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f26bcb25b19280a2e924c3895ef00525
https://doi.org/10.1016/j.brainresbull.2017.02.005