Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Lauren D. Van Wassenhove"'
Autor:
Amit U. Joshi, Lauren D. Van Wassenhove, Kelsey R. Logas, Paras S. Minhas, Katrin I. Andreasson, Kenneth I. Weinberg, Che-Hong Chen, Daria Mochly-Rosen
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-18 (2019)
Abstract Aldehyde dehydrogenase 2 deficiency (ALDH2*2) causes facial flushing in response to alcohol consumption in approximately 560 million East Asians. Recent meta-analysis demonstrated the potential link between ALDH2*2 mutation and Alzheimer’s
Externí odkaz:
https://doaj.org/article/91476726563c45a99cd6b718ef21b5bc
Autor:
Che-Hong Chen, Andrey V. Malkovskiy, Jayakumar Rajadas, Bradley Efron, Lauren D. Van Wassenhove, Kwame Osei-Sarfo, Daria Mochly-Rosen, Lorraine J. Gudas, Yury Goltsev
Publikováno v:
Calcified tissue international, vol 108, iss 2
Calcif Tissue Int
Calcif Tissue Int
ALDH2 inactivating mutation (ALDH2*2) is the most abundant mutation leading to bone morphological aberration. Osteoporosis has long been associated with changes in bone biomaterial in elderly populations. Such changes can be exacerbated with elevated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03fcfd34c1315e7ab232033dfb94df11
https://escholarship.org/uc/item/85f5h3wz
https://escholarship.org/uc/item/85f5h3wz
Autor:
Daria Mochly-Rosen, Kelsey R. Logas, Lauren D. Van Wassenhove, Kenneth I. Weinberg, Che-Hong Chen, Katrin I. Andreasson, Amit Joshi, Paras S. Minhas
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-18 (2019)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
Aldehyde dehydrogenase 2 deficiency (ALDH2*2) causes facial flushing in response to alcohol consumption in approximately 560 million East Asians. Recent meta-analysis demonstrated the potential link between ALDH2*2 mutation and Alzheimer’s Disease
Publikováno v:
Molecular Genetics and Metabolism. 119(1-2):28-36
Maintenance of the hematopoietic stem cell (HSC) compartment depends on the ability to metabolize exogenously and endogenously generated toxins, and to repair cellular damage caused by such toxins. Reactive aldehydes have been demonstrated to cause s
Autor:
Che-Hong Chen, Beruh Dejene, Daria Mochly-Rosen, Jennifer Tsai, Kelsey R. Logas, Kenneth I. Weinberg, Lauren D. Van Wassenhove
Publikováno v:
Blood. 134:105-105
HSC loss in FA is due to failure to resolve DNA inter-strand crosslinks (ICL), which can be induced by reactive aldehydes, radiation, or other clastogenic agents. Aldehyde exposure may occur through environmental sources, e.g. ingestion, absorption,
Autor:
Hongbin Cao, Aaron J Mattingly, Joshua Bloomstein, Hyun Shin Park, Eric T. Kool, Sarah M. Knox, Matthew C. Stevens, Dadi Jiang, Che-Hong Chen, Amanda Simmons, Julie P. Saiki, Lauren D. Van Wassenhove, Vignesh Viswanathan, Davud Sirjani, Daria Mochly-Rosen, Dhanya Nambiar, Rie von Eyben, Quynh-Thu Le
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 24
Xerostomia (dry mouth) is the most common side effect of radiation therapy in patients with head and neck cancer and causes difficulty speaking and swallowing. Since aldehyde dehydrogenase 3A1 (ALDH3A1) is highly expressed in mouse salivary stem/prog
Autor:
Chelsea Fournier, Zhi Fen Wu, Matthew J. Merrins, Charles R. Evans, Michelle L. Wynn, Sofia D. Merajver, Sydney A. Bridges, Sepideh Ashrafzadeh, Liwei Bao, Leslie S. Satin, Lauren D. Van Wassenhove, Charles F. Burant, Santiago Schnell, Joel A. Yates
Inflammatory breast cancer (IBC) is an extremely lethal cancer that rapidly metastasizes. Although the molecular attributes of IBC have been described, little is known about the underlying metabolic features of the disease. Using a variety of metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83e4805a23f6779da724d8439e9d9db6
https://europepmc.org/articles/PMC4919454/
https://europepmc.org/articles/PMC4919454/
Autor:
Alejandra C. Ventura, Peng Jiang, Sofia D. Merajver, Domitilla Del Vecchio, Alexander J. Ninfa, Lauren D. Van Wassenhove
We used a model system of purified components to explore the effects of a downstream target on the signaling properties of a covalent modification cycle, an example of retroactivity. In the experimental system used, a bifunctional enzyme catalyzed th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c14cb0b18307a219fb1502ecd1d99e
http://www.pnas.org/content/107/22/10032.long
http://www.pnas.org/content/107/22/10032.long
Publikováno v:
Protein Kinase C in Cancer Signaling and Therapy ISBN: 9781607615422
PKC expression is intimately associated with breast cancer initiation, progression, and therapy responsiveness, and these effects are highly isozyme-specific. PKC isozymes play key roles in proliferation and apoptosis of breast cancer cells and exert
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0934b1359d9e8c7c2703eafbb8b2f450
https://doi.org/10.1007/978-1-60761-543-9_17
https://doi.org/10.1007/978-1-60761-543-9_17
Autor:
Alejandra C. Ventura, Sofia D. Merajver, Megan Egbert, Santiago Schnell, Lauren D. Van Wassenhove, Michelle L. Wynn
Publikováno v:
The Breast. 22:S24-S25