Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Lauren Chessum"'
Autor:
Lucy A Dunbar, Pranav Patni, Carlos Aguilar, Philomena Mburu, Laura Corns, Helena RR Wells, Sedigheh Delmaghani, Andrew Parker, Stuart Johnson, Debbie Williams, Christopher T Esapa, Michelle M Simon, Lauren Chessum, Sherylanne Newton, Joanne Dorning, Prashanthini Jeyarajan, Susan Morse, Andrea Lelli, Gemma F Codner, Thibault Peineau, Suhasini R Gopal, Kumar N Alagramam, Ronna Hertzano, Didier Dulon, Sara Wells, Frances M Williams, Christine Petit, Sally J Dawson, Steve DM Brown, Walter Marcotti, Aziz El‐Amraoui, Michael R Bowl
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 9, Pp n/a-n/a (2019)
Abstract Hearing relies on mechanically gated ion channels present in the actin‐rich stereocilia bundles at the apical surface of cochlear hair cells. Our knowledge of the mechanisms underlying the formation and maintenance of the sound‐receptive
Externí odkaz:
https://doaj.org/article/aa32f3d7e38046868ba58a51eb9e8d12
Autor:
Paul K. Potter, Michael R. Bowl, Prashanthini Jeyarajan, Laura Wisby, Andrew Blease, Michelle E. Goldsworthy, Michelle M. Simon, Simon Greenaway, Vincent Michel, Alun Barnard, Carlos Aguilar, Thomas Agnew, Gareth Banks, Andrew Blake, Lauren Chessum, Joanne Dorning, Sara Falcone, Laurence Goosey, Shelley Harris, Andy Haynes, Ines Heise, Rosie Hillier, Tertius Hough, Angela Hoslin, Marie Hutchison, Ruairidh King, Saumya Kumar, Heena V. Lad, Gemma Law, Robert E. MacLaren, Susan Morse, Thomas Nicol, Andrew Parker, Karen Pickford, Siddharth Sethi, Becky Starbuck, Femke Stelma, Michael Cheeseman, Sally H. Cross, Russell G. Foster, Ian J. Jackson, Stuart N. Peirson, Rajesh V. Thakker, Tonia Vincent, Cheryl Scudamore, Sara Wells, Aziz El-Amraoui, Christine Petit, Abraham Acevedo-Arozena, Patrick M. Nolan, Roger Cox, Anne-Marie Mallon, Steve D. M. Brown
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Random mutagenesis can uncover novel genes involved in phenotypic traits. Here the authors perform a large-scale phenotypic screen on over 100 mouse strains generated by ENU mutagenesis to identify mice with age-related diseases, which they attribute
Externí odkaz:
https://doaj.org/article/fa97ab87303c498f824c8286a0325379
Autor:
Youming Zhang, Thanushiyan Poobalasingam, Laura L. Yates, Simone A. Walker, Martin S. Taylor, Lauren Chessum, Jackie Harrison, Loukia Tsaprouni, Ian M. Adcock, Clare M. Lloyd, William O. Cookson, Miriam F. Moffatt, Charlotte H. Dean
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 1 (2018)
We previously identified dipeptidylpeptidase 10 (DPP10) on chromosome 2 as a human asthma susceptibility gene, through positional cloning. Initial association results were confirmed in many subsequent association studies but the functional role of DP
Externí odkaz:
https://doaj.org/article/67ed6d54a0234aaa8bc3fcd1b739bff4
Autor:
Lauren Chessum, Sara Wells, Lydia Teboul, Adam Caulder, Nicolas Jullien, Jorik Loeffler, Marie-Christine Birling, Gemma F. Codner, Valerie Erbs
Publikováno v:
Methods
Methods, 2020, ⟨10.1016/j.ymeth.2020.06.011⟩
Methods, Elsevier, 2020, ⟨10.1016/j.ymeth.2020.06.011⟩
Methods, 2020, ⟨10.1016/j.ymeth.2020.06.011⟩
Methods, Elsevier, 2020, ⟨10.1016/j.ymeth.2020.06.011⟩
The widespread availability of recombineered vectors and gene targeted embryonic stem cells from large-scale repositories facilitates the generation of mouse models for functional genetic studies. Southern blotting validates the structure of these ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0b1ad57e2e66bd381133ea249dcfe79
https://hal.science/hal-03226116
https://hal.science/hal-03226116
Autor:
Michael R. Bowl, Elsa Rossignol, Mattéa J. Finelli, Enrico Castroflorio, Lauren Chessum, Davide Aprile, Anna Fassio, Andrew R. Bassett, Alexis Lupien-Meilleur, Philippe M. Campeau, Julia Grasegger, Peter L. Oliver, Matteo T. Degiacomi, Matteo Moschetta, Fabio Benfenati, Alexander Jeans
Publikováno v:
Human Molecular Genetics
Human molecular genetics, 2019, Vol.28(4), pp.584-597 [Peer Reviewed Journal]
Human molecular genetics, 2019, Vol.28(4), pp.584-597 [Peer Reviewed Journal]
Mutations in the Tre2/Bub2/Cdc16 (TBC)1 domain family member 24 (TBC1D24) gene are associated with a range of inherited neurological disorders, from drug-refractory lethal epileptic encephalopathy and DOORS syndrome (deafness, onychodystrophy, osteod
Autor:
Aziz El-Amraoui, Stuart L. Johnson, Christine Petit, Michelle Simon, Prashanthini Jeyarajan, Lauren Chessum, Michael R. Bowl, Sherylanne Newton, Andrea Lelli, Helena Rr Wells, Frances M K Williams, Andrew Parker, Joanne Dorning, Didier Dulon, Susan Morse, Suhasini R. Gopal, Steve D.M. Brown, Sedigheh Delmaghani, Philomena Mburu, Christopher T. Esapa, Ronna Hertzano, Sara Wells, Debbie Williams, Carlos A. Aguilar, Kumar N. Alagramam, Pranav Patni, Thibault Peineau, Walter Marcotti, Laura F. Corns, Sally J. Dawson, Gemma F. Codner, Lucy A Dunbar
Publikováno v:
EMBO Molecular Medicine
EMBO Molecular Medicine, Wiley Open Access, 2019, 11 (9), pp.e10288. ⟨10.15252/emmm.201910288⟩
EMBO Molecular Medicine, 2019, 11 (9), pp.e10288. ⟨10.15252/emmm.201910288⟩
EMBO Molecular Medicine, Vol 11, Iss 9, Pp n/a-n/a (2019)
EMBO Molecular Medicine, Wiley Open Access, 2019, 11 (9), pp.e10288. ⟨10.15252/emmm.201910288⟩
EMBO Molecular Medicine, 2019, 11 (9), pp.e10288. ⟨10.15252/emmm.201910288⟩
EMBO Molecular Medicine, Vol 11, Iss 9, Pp n/a-n/a (2019)
International audience; Hearing relies on mechanically gated ion channels present in the actin-rich stereocilia bundles at the apical surface of cochlear hair cells. Our knowledge of the mechanisms underlying the formation and maintenance of the soun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edaae1d8c8cc8054398a9affa8ff41c6
https://hal-pasteur.archives-ouvertes.fr/pasteur-03261798/document
https://hal-pasteur.archives-ouvertes.fr/pasteur-03261798/document
Autor:
Andrew Parker, Jack A. Prescott, Graham P. Trent, Yang Song, Elizabeth C. Driver, Yoko Ogawa, Beatrice Milon, Michael R. Bowl, Walter Marcotti, Lauren Chessum, Steve D.M. Brown, Abigail K. Dragich, Mark McMurray, Stuart L. Johnson, Ronna Hertzano, Gemma F. Codner, Michael C. Kelly, Sara Wells, Ran Elkon, Gregory I. Frolenkov, Matthew W. Kelley, Christopher T. Esapa, Maggie S. Matern
Publikováno v:
Nature
The sensory cells that are responsible for hearing include the cochlear inner hair cells (IHCs) and outer hair cells (OHCs), with the OHCs being necessary for sound sensitivity and tuning1. Both cell types are thought to arise from common progenitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::649ebf04ce5b1b36043ae735bebf58b9
https://eprints.whiterose.ac.uk/146863/1/EMS80307.pdf
https://eprints.whiterose.ac.uk/146863/1/EMS80307.pdf
Publikováno v:
Current Protocols in Mouse Biology
Mice are an invaluable model organism for the study of auditory function. Even though there are differences in size and frequency response, the anatomy and physiology of the mouse and human ear are remarkably similar. In addition, the tools available
Autor:
Carlos A. Aguilar, Becky Starbuck, Siddharth Sethi, Paul Potter, Gemma Law, Marie Hutchison, Ruairidh King, Gareth Banks, Anne-Marie Mallon, Ines Heise, Thomas Agnew, Vincent Michel, Rosie Hillier, Femke Stelma, Patrick M. Nolan, Aziz El-Amraoui, Michelle Simon, Laura Wisby, Shelley Harris, Susan Morse, Laurence Goosey, Ian J. Jackson, Steve D. M. Brown, Lauren Chessum, Michelle Goldsworthy, Robert E MacLaren, Saumya Kumar, Michael Cheeseman, Andrew Parker, Sara Wells, Christine Petit, Sally H. Cross, Cheryl L. Scudamore, Stuart N. Peirson, Simon Greenaway, Heena V. Lad, Rajesh V. Thakker, Prashanthini Jeyarajan, Abraham Acevedo-Arozena, Andrew Blake, Karen Pickford, Sara Falcone, T Nicol, Angela Hoslin, Andy Haynes, Alun R. Barnard, Tonia L. Vincent, Russell G. Foster, Tertius Hough, Joanne Dorning, Michael R. Bowl, Roger D. Cox, A Blease
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications
Nature Communications, 2016, 7, pp.12444. ⟨10.1038/ncomms12444⟩
Potter, P K, Bowl, M R, Jeyarajan, P, Wisby, L, Blease, A, Goldsworthy, M E, Simon, M M, Greenaway, S, Michel, V, Barnard, A, Aguilar, C, Agnew, T, Banks, G, Blake, A, Chessum, L, Dorning, J, Falcone, S, Goosey, L, Harris, S, Haynes, A, Heise, I, Hillier, R, Hough, T, Hoslin, A, Hutchison, M, King, R, Kumar, S, Lad, H V, Law, G, MacLaren, R E, Morse, S, Nicol, T, Parker, A, Pickford, K, Sethi, S, Starbuck, B, Stelma, F, Cheeseman, M, Cross, S H, Foster, R G, Jackson, I J, Peirson, S N, Thakker, R V, Vincent, T, Scudamore, C, Wells, S, El-Amraoui, A, Petit, C, Acevedo-Arozena, A, Nolan, P M, Cox, R, Mallon, A-M & Brown, S D M 2016, ' Novel gene function revealed by mouse mutagenesis screens for models of age-related disease ', Nature Communications, vol. 7, 12444 . https://doi.org/10.1038/ncomms12444
Nature Communications
Nature Communications, 2016, 7, pp.12444. ⟨10.1038/ncomms12444⟩
Potter, P K, Bowl, M R, Jeyarajan, P, Wisby, L, Blease, A, Goldsworthy, M E, Simon, M M, Greenaway, S, Michel, V, Barnard, A, Aguilar, C, Agnew, T, Banks, G, Blake, A, Chessum, L, Dorning, J, Falcone, S, Goosey, L, Harris, S, Haynes, A, Heise, I, Hillier, R, Hough, T, Hoslin, A, Hutchison, M, King, R, Kumar, S, Lad, H V, Law, G, MacLaren, R E, Morse, S, Nicol, T, Parker, A, Pickford, K, Sethi, S, Starbuck, B, Stelma, F, Cheeseman, M, Cross, S H, Foster, R G, Jackson, I J, Peirson, S N, Thakker, R V, Vincent, T, Scudamore, C, Wells, S, El-Amraoui, A, Petit, C, Acevedo-Arozena, A, Nolan, P M, Cox, R, Mallon, A-M & Brown, S D M 2016, ' Novel gene function revealed by mouse mutagenesis screens for models of age-related disease ', Nature Communications, vol. 7, 12444 . https://doi.org/10.1038/ncomms12444
Determining the genetic bases of age-related disease remains a major challenge requiring a spectrum of approaches from human and clinical genetics to the utilization of model organism studies. Here we report a large-scale genetic screen in mice emplo
Autor:
Susan Morse, Elizabeth Smart, Robert E MacLaren, Sara Wells, Alun R. Barnard, Michael R. Bowl, Lauren Chessum, Andrew Parker, Stuart L. Johnson, Rachel E. Hardisty-Hughes, Walter Marcotti, Joanne Dorning, Melissa West, Carlos Aguilar, Leanne Carrott, Steve D. M. Brown, Greg Ball
Publikováno v:
The Journal of Neuroscience. 36:222-234
TheNeuroplastingene encodes two synapse-enriched protein isoforms, Np55 and Np65, which are transmembrane glycoproteins that regulate several cellular processes, including the genesis, maintenance, and plasticity of synapses. We found that an absence