Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Lauren Cech"'
Autor:
Franziska Haderk, Yu-Ting Chou, Lauren Cech, Celia Fernández-Méndez, Johnny Yu, Victor Olivas, Ismail M. Meraz, Dora Barbosa Rabago, D. Lucas Kerr, Carlos Gomez, David V. Allegakoen, Juan Guan, Khyati N. Shah, Kari A. Herrington, Oghenekevwe M. Gbenedio, Shigeki Nanjo, Mourad Majidi, Whitney Tamaki, Yashar K. Pourmoghadam, Julia K. Rotow, Caroline E. McCoach, Jonathan W. Riess, J. Silvio Gutkind, Tracy T. Tang, Leonard Post, Bo Huang, Pilar Santisteban, Hani Goodarzi, Sourav Bandyopadhyay, Calvin J. Kuo, Jeroen P. Roose, Wei Wu, Collin M. Blakely, Jack A. Roth, Trever G. Bivona
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Targeted therapy is effective in many tumor types including lung cancer, the leading cause of cancer mortality. Paradigm defining examples are targeted therapies directed against non-small cell lung cancer (NSCLC) subtypes with oncogenic alt
Externí odkaz:
https://doaj.org/article/be0a7eca3725431ab19bfe58739629b9
Autor:
Timothy P. Spicer, R. Luke Wiseman, Christina B. Cooley, Lauren Cech, Louis Scampavia, Bryan O. Seguinot, Lars Plate, Evan T. Powers, Julia M. D. Grandjean, Jeffery W. Kelly, Aparajita Madhavan, Emery Smith, Ryan J Paxman
Publikováno v:
Nature Chemical Biology. 16:1052-1061
Activation of the IRE1/XBP1s signaling arm of the unfolded protein response (UPR) is a promising strategy to correct defects in endoplasmic reticulum (ER) proteostasis implicated in diverse diseases. However, no pharmacologic activators of this pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14e0cd8b201d997aeaeac068f8f901b7
https://doi.org/10.1038/s41589-020-0584-z
https://doi.org/10.1038/s41589-020-0584-z
Autor:
Manasi Mayekar, Deborah Caswell, Natalie Vokes, Emily K. Law, Wei Wu, William Hill, Eva Gronroos, Andrew Rowan, Maise Al Bakir, Clare Weeden, Caroline E. McCoach, Collin M. Blakely, Nuri Alpay Temiz, Ai Nagano, Daniel L. Kerr, Julia K. Rotow, Oriol Pich, Franziska Haderk, Michelle Dietzen, Carlos Martinez Ruiz, Bruna Almeida, Lauren Cech, Beatrice Gini, Joanna Przewrocka, Chris Moore, Miguel Murillo, Bjorn Bakker, Brandon Rule, Cameron Durfee, Shigeki Nanj, Lisa Tan, Lindsay K. Larson, Prokopios P. Argyris, William L. Brown, Johnny Yu, Carlos Gomez, Philippe Gui, Rachel I. Vogel, Elizabeth A. Yu, Nicholas J. Thomas, Subramanian Venkatesan, Sebastijan Hobor, Su Kit Chew, Nicholas McGranahan, Nnennaya Kanu, Eliezer M. Van Allen, Julian Downward, Reuben S. Harris, Trever Bivona, Charles Swanton
Publikováno v:
Cancer Research. 82:2197-2197
Introduction: Increasing our understanding of drivers of mutagenesis in lung cancer is critical in our efforts to prevent tumor reoccurrence and resistance. Results: Using the multi-region TRACERx lung cancer study, we uncovered that APOBEC3B is sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93c49478ed5c7c84f95d81176cd804c0
https://doi.org/10.1158/1538-7445.am2022-2197
https://doi.org/10.1158/1538-7445.am2022-2197
Autor:
Brandon Rule, Collin M. Blakely, Julian Downward, Charles Swanton, Subramanian Venkatesan, Beatrice Gini, Nnennaya Kanu, Elizabeth A. Yu, William Hill, Manasi K. Mayekar, Bjorn Bakker, Ai Nagano, Shigeki Nanjo, Andrew Rowan, Philippe Gui, Lindsay K. Larson, Carlos Martinez Ruiz, Reuben S. Harris, Emily K. Law, Daniel Lucas Kerr, Deborah R. Caswell, Nuri A. Temiz, Su Kit Chew, Franziska Haderk, Christopher I. Moore, Natalie I. Vokes, Sebastijan Hobor, Wei Wu, Prokopios P. Argyris, Michelle Dietzen, Johnny Yu, Rachel Isaksson Vogel, Bruna Almeida, Carlos Gomez, Trever G. Bivona, Eliezer M. Van Allen, Maise Al Bakir, Cameron Durfee, Julia K Rotow, Nicholas J. Thomas, Eva Grönroos, Lisa Tan, Nicholas McGranahan, Lauren Cech, William L. Brown, Miguel M. Murillo, Caroline E. McCoach, Joanna Przewrocka
Introductory paragraphThe clinical success of targeted cancer therapy is limited by drug resistance that renders cancers lethal in patients1-4. Human tumours can evolve therapy resistance by acquiringde novogenetic alterations and increased heterogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e88669dbc506986684565de05cabf66a
https://doi.org/10.1101/2020.12.18.423280
https://doi.org/10.1101/2020.12.18.423280
Autor:
Erin L. Schenk, Thierry Jahan, Trever G. Bivona, Anshal Gupta, Rafael Gomez-Sjoberg, Norma Neff, Nicholas J. Thomas, Franziska Haderk, Bianca Bacaltos, Spyros Darmanis, Pallav K. Kolli, Hien Do, Johannes R. Kratz, D. Lucas Kerr, Robert C. Doebele, Khyati N. Shah, Julia K Rotow, Mayra Gonzalez, Matthew A. Gubens, Yaron Gesthalter, Caroline E. McCoach, Kirk D. Jones, Eric J. Seeley, Anatoly Urisman, Ashley Maynard, Daniel D. Le, Michelle Tan, Philippe Gui, Lisa Tan, Weilun Tan, Tasha Lea, Sourav Bandyopadhyay, David M. Naeger, Lincoln Harris, Collin M. Blakely, Lauren Cech, Alexander Zee, David M. Jablons, Rene Sit, Wei Wu, Jonathan S. Weissman, Kevin A. Yamauchi, Elizabeth A. Yu
Publikováno v:
Cell
Summary Lung cancer, the leading cause of cancer mortality, exhibits heterogeneity that enables adaptability, limits therapeutic success, and remains incompletely understood. Single-cell RNA sequencing (scRNA-seq) of metastatic lung cancer was perfor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::794e39225d45574e5c6f24ca9d417b48
https://pubmed.ncbi.nlm.nih.gov/32822576
https://pubmed.ncbi.nlm.nih.gov/32822576
Autor:
Julia M D, Grandjean, Aparajita, Madhavan, Lauren, Cech, Bryan O, Seguinot, Ryan J, Paxman, Emery, Smith, Louis, Scampavia, Evan T, Powers, Christina B, Cooley, Lars, Plate, Timothy P, Spicer, Jeffery W, Kelly, R Luke, Wiseman
Publikováno v:
Nature chemical biology. 16(10)
Activation of the IRE1/XBP1s signaling arm of the unfolded protein response (UPR) is a promising strategy to correct defects in endoplasmic reticulum (ER) proteostasis implicated in diverse diseases. However, no pharmacologic activators of this pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3f4323cc55d9629c0ba6ed0c9be200c0
https://pubmed.ncbi.nlm.nih.gov/32704180
https://pubmed.ncbi.nlm.nih.gov/32704180