Výsledky vyhledávání - "Lauren C. DeSantis"

Deletion of the brain-specific α and δ isoforms of adapter protein SH2B1 protects mice from obesity

Autor: Christin Carter-Su, Martin G. Myers, Jr, Ormond A. MacDougald, Gowri Chandrashekar, Erik S. Clutter, Abrielle M. Cacciaglia, Paul B. Vander, Devika P. Bagchi, Alexander H. Bedard, Lauren C. DeSantis, Joel M. Cline, Alan C. Rupp, Anabel Flores, Lawrence S. Argetsinger, Jessica L. Cote, Ada Admin

Mice lacking SH2B1 and humans with inactivating mutations of SH2B1 display severe obesity and insulin resistance. SH2B1 is an adapter protein that is recruited to the receptors of multiple hormones and neurotrophic factors. Of the four known alternat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a79c3cf7a5184c1d76cfda90893f0213
https://doi.org/10.2337/figshare.13229090.v1

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OR12-6 Deletion Of The Brain-Specific α And δ Isoforms Of SH2B1 Protects Against Diet-Induced Obesity In A Leptin-Independent Manner

Autor: Martin G. Myers, Joel M. Cline, Erik S. Clutter, Anabel Flores, Lauren C. DeSantis, Alexander H Bedard, Christin Carter-Su, Abrielle M Cacciaglia, Lawrence S. Argetsinger, Jessica L. Cote

Publikováno v: Journal of the Endocrine Society

The scaffold protein SH2B1 plays a critical role in the regulation of energy balance and glucose homeostasis—humans with mutations in SH2B1 are obese and diabetic, as are SH2B1KO mice. The 4 known isoforms of SH2B1 (α, β, γ, δ), which differ on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a681d5993a1572a0806c3be1a2c6f7
https://doi.org/10.1210/js.2019-or12-6