Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Lauren C. Binge"'
Autor:
Charles R. Mackay, Lauren C. Binge, Alyce J. Nicholls, Connie H.Y. Wong, Ana Carolina Oliveira, Marjon E. Kamp, Raymond Shim, Linda J. Mason
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 9, p e0163750 (2016)
PLoS ONE, Vol 11, Iss 9, p e0163750 (2016)
Fermentation of dietary fibre in the gut yields large amounts of short chain fatty acids (SCFAs). SCFAs can impart biological responses in cells through their engagement of 'metabolite-sensing' G protein-coupled receptors (GPCRs). One of the main SCF
Publikováno v:
Diabetes
For autoimmune conditions like type 1 diabetes to progress, self-reactive CD8+ T cells would need to interact with peptide–antigen cross-presented on the surface of antigen-presenting cells in a major histocompatibility complex (MHC) class I-restri
Autor:
Eliana Mariño, Lauren C. Binge, Charles R. Mackay, Kendle M. Maslowski, Kate E. Rogers, Jan Kranich, Angélica T. Vieira, Laurence Macia, Alison N. Thorburn
Publikováno v:
Immunological Reviews. 245:164-176
Certain autoimmune diseases as well as asthma have increased in recent decades, particularly in developed countries. The hygiene hypothesis has been the prevailing model to account for this increase; however, epidemiology studies also support the con
Autor:
Jennifer M Dyson, Meredith J. Layton, Steven Petratos, Lauren C. Binge, Adam R. Cole, Christina Anne Mitchell, Lisa M Ooms, Calum Sutherland, Megan Victoria Astle
Publikováno v:
Journal of Biological Chemistry. 286:23407-23418
Neuron polarization is essential for the formation of one axon and multiple dendrites, establishing the neuronal circuitry. Phosphoinositide 3-kinase (PI3K) signaling promotes axon selection and elongation. Here we report in hippocampal neurons siRNA
Autor:
Tony Tiganis, Ivan Ivetac, David A. Sheffield, Christina Anne Mitchell, Rajendra Gurung, Lauren C. Binge, Philip W. Majerus, Sandra Hakim, Kristy A. Horan
Publikováno v:
EMBO reports. 10:487-493
Akt is a crucial phosphoinositide 3-kinase (PI(3)K) effector that regulates cell proliferation and survival. PI(3)K-generated signals, PtdIns(3,4,5)P(3) and PtdIns(3,4)P(2), direct Akt plasma membrane engagement. Pathological Akt plasma membrane asso
Autor:
Katie Leach, Nina Chevalier, Robert J. Moore, Suzanne Luong, Caroline Ang, Jian Tan, Charles R. Mackay, Atsushi Hijikata, Mikako Maruya, Lauren C. Binge, Richard A. Flavell, Dragana Stanley, Alison N. Thorburn, Craig R. M. McKenzie, Angélica T. Vieira, Sidonia Fagarasan, Laurence Macia, Connie H.Y. Wong, Mauro M. Teixeira, Stefan Offermanns, Eliana Mariño, Remy Robert
Publikováno v:
Nature Communications. 6
Diet and the gut microbiota may underpin numerous human diseases. A major metabolic product of commensal bacteria are short-chain fatty acids (SCFAs) that derive from fermentation of dietary fibre. Here we show that diets deficient or low in fibre ex
Autor:
Clare G Fedele, Antonella Papa, Rajendra Gurung, Lauren C. Binge, Parvin Rahman, Daniel T. Ferguson, Catriona McLean, Ryan C. Chai, John T. Price, Paul Timpson, Lisa M Ooms, James R.W. Conway, Frank Koentgen, Jessica L. Vieusseux, Tony Tiganis, Elizabeth M Davies, Christina Anne Mitchell
Publikováno v:
Cancer cell. 28(2)
SummaryMetastasis is the major cause of breast cancer mortality. Phosphoinositide 3-kinase (PI3K) generated PtdIns(3,4,5)P3 activates AKT, which promotes breast cancer cell proliferation and regulates migration. To date, none of the inositol polyphos
Autor:
Paul Anthony Robinson, Hong Wang, Susan Brown, Jennifer M. Dyson, Denny L Cottle, Clare G Fedele, David Pook, Lauren C. Binge, Belinda S. Cowling, Meagan Jane Mcgrath, Absorn Sriratana, Christina Anne Mitchell, Gail P. Risbridger, Birunthi Niranjan
Publikováno v:
Cancer research. 73(16)
It is now clear that progression from localized prostate cancer to incurable castrate-resistant prostate cancer (CRPC) is driven by continued androgen receptor (AR), signaling independently of androgen. Thus, there remains a strong rationale to suppr
Autor:
Laurence, Macia, Alison N, Thorburn, Lauren C, Binge, Eliana, Marino, Kate E, Rogers, Kendle M, Maslowski, Angélica T, Vieira, Jan, Kranich, Charles R, Mackay
Publikováno v:
Immunological reviews. 245(1)
Certain autoimmune diseases as well as asthma have increased in recent decades, particularly in developed countries. The hygiene hypothesis has been the prevailing model to account for this increase; however, epidemiology studies also support the con
Publikováno v:
Diabetes
Marino E, Tan B, Binge L, Mackay CR, Grey ST. B-Cell cross-presentation of autologous antigen precipitates diabetes. Diabetes …