Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Lauren Bathurst"'
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100068 (2014)
The assessment of BRCA1 and BRCA2 coding sequences to identify pathogenic mutations associated with inherited breast/ovarian cancer syndrome has provided a method to identify high-risk individuals, allowing them to seek preventative treatments and st
Externí odkaz:
https://doaj.org/article/3489aa0bd41d4e55bb452568a2077e5b
Autor:
Cheryl Crozier, Lauren Bathurst, Melanie Spears, Jane Bayani, John M. S. Bartlett, Linda Liao
Publikováno v:
Cancer Research. 80:PD2-10
Background: For treatment of metastatic or advanced ER+/HER2- breast cancer, CDK4/6 inhibition (CDKi), including CDK4/6 inhibitors palbociclib, ribociclib and abemaciclib, is now the standard of care. Approximately 25% of patients however will not re
Autor:
Julie Livingstone, Lincoln Stein, Cheryl Crozier, Gun Ho Jang, Cindy Q. Yao, Melanie Spears, Lauren Bathurst, Paul C. Boutros, John Douglas Mcpherson, Jane Bayani, Daniel Rea, Quang M. Trinh, Elizabeth N. Kornaga, Irina Kalatskaya, John M. S. Bartlett
Publikováno v:
JCO Precision Oncology. :1-13
PURPOSE Hormone receptor–positive breast cancer remains an ongoing therapeutic challenge, despite optimal anti-endocrine therapies. In this study, we assessed the prognostic ability of genomic signatures to identify patients at risk for recurrence
Publikováno v:
Cancer Research. 73:1931-1931
Germline mutations in the breast cancer susceptibility gene BRCA1 confer an overall lifetime risk of developing breast cancer of up to 80%. Given the high risk of cancer development associated with BRCA1 mutation carriers, it is important that they b
Publikováno v:
Cancer Research. 72:693-693
While most breast cancers are sporadic, 5-10% are hereditary and attributable to the presence of a mutation in the breast cancer associated gene 1 (BRCA1). The BRCA1 gene encodes a tumour suppressor with several well described roles in maintaining ge