Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Lauren B. Pickens"'
Publikováno v:
Angewandte Chemie International Edition. 51:11136-11140
A very accommodating host: Three tetracycline biosynthetic pathways were overexpressed and manipulated in the heterologous host Streptomyces lividans K4-114. Through the inactivation of various genes and characterization of the resulting biosynthetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::665c0ea397ddc3aef7f9e0173f72c2a1
https://doi.org/10.1002/anie.201205426
https://doi.org/10.1002/anie.201205426
Publikováno v:
Journal of Biological Chemistry. 286:41539-41551
SsfX3 is a GDSL family acyltransferase that transfers salicylate to the C-4 hydroxyl of a tetracycline intermediate in the penultimate step during biosynthesis of the anticancer natural product SF2575. The C-4 salicylate takes the place of the more c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::471b2a7bb8d10c7af554da40c82a5ad5
https://doi.org/10.1074/jbc.m111.299859
https://doi.org/10.1074/jbc.m111.299859
Autor:
Yi Tang, Lauren B. Pickens
Publikováno v:
Metabolic Engineering. 11:69-75
Tetracyclines have been important agents in combating infectious disease since their discovery in the mid-twentieth century. Following widespread use, tetracycline resistance mechanisms emerged and continue to create a need for new derivatives that a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7711ef0539e41df897a69bb58e1973f2
https://doi.org/10.1016/j.ymben.2008.10.001
https://doi.org/10.1016/j.ymben.2008.10.001
Autor:
Lauren B. Pickens, Yi Tang
Oxytetracycline (OTC) is a broad-spectrum antibiotic that acts by inhibiting protein synthesis in bacteria. It is an important member of the bacterial aromatic polyketide family, which is a structurally diverse class of natural products. OTC is synth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a32e659edd7aeac0b1d2c932e2997b95
https://europepmc.org/articles/PMC2934616/
https://europepmc.org/articles/PMC2934616/
Publikováno v:
Encyclopedia of Industrial Biotechnology ISBN: 9780471799306
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cc69d32376d6130a65452188c698ba6
https://doi.org/10.1002/9780470054581.eib041
https://doi.org/10.1002/9780470054581.eib041
SF2575 1 is a tetracycline polyketide produced by Streptomyces sp. SF2575 and displays exceptionally potent anticancer activity toward a broad range of cancer cell lines. The structure of SF2575 is characterized by a highly substituted tetracycline a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8c119e83bda617ddf1ec7e88735a270
https://europepmc.org/articles/PMC2800175/
https://europepmc.org/articles/PMC2800175/