Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Lauren B. Kinner-Bibeau"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract The release of Heat Shock Proteins (HSPs) from aberrant cells can initiate immune responses following engagement of the HSPs with antigen presenting cells (APCs). This is an important mechanism for cancer immunosurveillance and can also be m
Externí odkaz:
https://doaj.org/article/97d4f75192d24757a9d884d4ad3eb92d
Autor:
Lauren B. Kinner-Bibeau, Abigail L. Sedlacek, Michelle N. Messmer, Simon C. Watkins, Robert J. Binder
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Low dose of the heat shock protein gp96 can drive effector T-cell responses, yet high-dose gp96 is immunosuppressive by expanding the regulatory T-cell population. Here the authors explain this dichotomy by showing that high-dose gp96 can drive plasm
Externí odkaz:
https://doaj.org/article/cf78ebbf481d47ad9ecf5de60d0357a8
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
The release of Heat Shock Proteins (HSPs) from aberrant cells can initiate immune responses following engagement of the HSPs with antigen presenting cells (APCs). This is an important mechanism for cancer immunosurveillance and can also be modeled by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681aff4b23fa6a8646591204a47b21b9
http://europepmc.org/articles/PMC8352880
http://europepmc.org/articles/PMC8352880
Autor:
Robert J. Binder, Abigail L. Sedlacek, Lauren B. Kinner-Bibeau, Simon C. Watkins, Michelle N. Messmer
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Immune responses primed by endogenous heat shock proteins, specifically gp96, can be varied, and mechanisms controlling these responses have not been defined. Immunization with low doses of gp96 primes T helper type 1 (Th1) immune responses, whereas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca3c5a557bc14b6b28101fa90558ff8
https://doi.org/10.1038/ncomms15648
https://doi.org/10.1038/ncomms15648
Distinct heat shock protein-mediated immune responses are induced by macrophages and dendritic cells
Publikováno v:
The Journal of Immunology. 202:59.10-59.10
Heat shock proteins (HSPs) induce potent immune responses against their chaperoned antigens and thus have potential as cancer immunotherapy. APCs, T cells, and NK cells are all required in HSP-mediated immune responses. NK cells are activated indirec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce573a83c5b7500b5def966db10c2c8d
https://doi.org/10.4049/jimmunol.202.supp.59.10
https://doi.org/10.4049/jimmunol.202.supp.59.10
Publikováno v:
Scientific Reports
A number of Heat Shock Proteins (HSPs), in the extracellular environment, are immunogenic. Following cross-presentation of HSP-chaperoned peptides by CD91+ antigen presenting cells (APCs), T cells are primed with specificity for the derivative antige
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f78474201b53044b02736dadfffa3c