Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Lauren B. Becnel"'
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Akademický článek
A FAIR-Based Approach to Enhancing the Discovery and Re-Use of Transcriptomic Data Assets for Nuclear Receptor Signaling Pathways
Autor: Scott A. Ochsner, Yolanda F. Darlington, Apollo McOwiti, Wasula H. Kankanamge, Alexey Naumov, Lauren B. Becnel, Neil J. McKenna
Publikováno v: Data Science Journal, Vol 16 (2017)
Public transcriptomic assets in the nuclear receptor (NR) signaling field hold considerable collective potential for exposing underappreciated aspects of NR regulation of gene expression. This potential is undermined however by a series of enduring i
Externí odkaz: https://doaj.org/article/455cc8ad64904b639b5cbb5455f1c8dc
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3
Use of Real-World Evidence to Drive Drug Development Strategy and Inform Clinical Trial Design
Autor: Jen Webster, Simon Dagenais, Leo Russo, Lauren B. Becnel, Ann Madsen
Publikováno v: Clinical pharmacology and therapeutics. 111(1)
Interest in real-world data (RWD) and real-world evidence (RWE) to expedite and enrich the development of new biopharmaceutical products has proliferated in recent years, spurred by the 21st Century Cures Act in the United States and similar policy e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b464851dfe45c802940428ba89da88e4
https://pubmed.ncbi.nlm.nih.gov/34839524
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4
Presenting and sharing clinical data using the eTRIKS Standards Master Tree for tranSMART
Autor: Kavita Rege, Andreas Tielmann, Rudi Balling, Sascha Herzinger, Dorina Bratfalean, Venkata P. Satagopam, Reinhard Schneider, Paul Houston, Adriano Barbosa-Silva, Paul Peeters, Fabien Richard, Serge Eifes, Wei Gu, Lauren B. Becnel
Publikováno v: Bioinformatics
Bioinformatics, 809. (2018).
Motivation Standardization and semantic alignment have been considered one of the major challenges for data integration in clinical research. The inclusion of the CDISC SDTM clinical data standard into the tranSMART i2b2 via a guiding master ontology
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c9b6b56f214a2a29a34b02d68a5736c
https://doi.org/10.1093/bioinformatics/bty809
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5
BRIDG: a domain information model for translational and clinical protocol-driven research
Autor: Michael L. Glickman, Diane Wold, MaryAnn Slack, Boris Brodsky, Edward Helton, Wendy Ver Hoef, Smita Hastak, Lauren B. Becnel, Rebecca Daniels Kush, Robert P. Milius, Charles Jaffe
Publikováno v: Journal of the American Medical Informatics Association. 24:882-890
Background: It is critical to integrate and analyze data from biological, translational, and clinical studies with data from health systems; however, electronic artifacts are stored in thousands of disparate systems that are often unable to readily e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d89a67e65855f674d5f090a5a36d88
https://doi.org/10.1093/jamia/ocx004
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7
FAIR data sharing: The roles of common data elements and harmonization
Autor: Tammy Jackson, Frank Pétavy, Barbara Jauregui, Jose Galvez, Lynn D. Hudson, Denise Warzel, Rebecca Daniels Kush, Eileen A. Navarro, Ronald D. Fitzmartin, Lauren B. Becnel, Alexander Sherman, F. L. Zhou, Nicole Harmon, Maura A. Kush
Publikováno v: Journal of biomedical informatics. 107
The value of robust and responsible data sharing in clinical research and healthcare is recognized by patients, patient advocacy groups, researchers, journal editors, and the healthcare industry globally. Privacy and security concerns acknowledged, t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4106a7c5ceec969eebedb5493e5b1ad
https://pubmed.ncbi.nlm.nih.gov/32407878
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8
Use of EHRs data for clinical research: Historical progress and current applications
Autor: Amy Harris Nordo, Prasanna Rao, Komathi Stem, Hugh P. Levaux, Jose Galvez, Era Prakash, Lauren B. Becnel, Rebecca Daniels Kush
Publikováno v: Learning Health Systems
The benefits of reusing EHR data for clinical research studies are numerous. They portend the opportunity to bring new therapies to patients sooner, potentially at a lower cost, and to accelerate learning health cycles—through faster data acquisiti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622ccb68f4c7dd8956f9cc0839a320f1
http://europepmc.org/articles/PMC6508843
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9
Acquire: an open-source comprehensive cancer biobanking system
Autor: Lauren B. Becnel, Benjamin Pew, Heidi Dowst, Shijing Qu, Christopher M. Watkins, Jonathan Barney, Apollo McOwiti
Publikováno v: Bioinformatics
Motivation: The probability of effective treatment of cancer with a targeted therapeutic can be improved for patients with defined genotypes containing actionable mutations. To this end, many human cancer biobanks are integrating more tightly with ge
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::944610dc9905e2d128a10b354a2867d4
https://doi.org/10.1093/bioinformatics/btv012
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