Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Lauren Abell"'
Autor:
Kiyoto Nishi, Akira Yoshii, Lauren Abell, Bo Zhou, Ricardo Frausto, Julia Ritterhoff, Timothy S. McMillen, Ian Sweet, Yibin Wang, Chen Gao, Rong Tian
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112641- (2023)
Summary: Branched-chain amino acid (BCAA) metabolism is linked to glucose homeostasis, but the underlying signaling mechanisms are unclear. We find that gluconeogenesis is reduced in mice deficient of Ppm1k, a positive regulator of BCAA catabolism, w
Externí odkaz:
https://doaj.org/article/f43a4a961cc14f469d68140c703a2479
Autor:
Jason W. Miklas, Shiri Levy, Peter Hofsteen, Diego Ic Mex, Elisa Clark, Jeanot Muster, Aaron M. Robitaille, Gargi Sivaram, Lauren Abell, Jamie M. Goodson, Inez Pranoto, Anup Madan, Michael T. Chin, Rong Tian, Charles E. Murry, Randall T. Moon, Yuliang Wang, Hannele Ruohola-Baker
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103574- (2022)
Summary: Heart disease is the leading cause of death with no method to repair damaged myocardium due to the limited proliferative capacity of adult cardiomyocytes. Curiously, mouse neonates and zebrafish can regenerate their hearts via cardiomyocyte
Externí odkaz:
https://doaj.org/article/642e6fbe603b46798aadc2710661e1bb
Publikováno v:
Analytical Chemistry. 95:6029-6037
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::801609f0ae173684a96e10ef038be466
https://doi.org/10.1021/acs.analchem.3c00054
https://doi.org/10.1021/acs.analchem.3c00054
Autor:
Kiyoto Nishi, Lauren Abell, Ricardo Frausto, Julia Ritterhoff, Timothy McMillen, Ian Sweet, Yibin Wang, Chen Gao, Rong Tian
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24a61dfc41f05e790fbd9d293e1efc94
https://doi.org/10.2139/ssrn.4022706
https://doi.org/10.2139/ssrn.4022706
Autor:
Jason W. Miklas, Shiri Levy, Peter Hofsteen, Diego Ic Mex, Elisa Clark, Jeanot Muster, Aaron M. Robitaille, Gargi Sivaram, Lauren Abell, Jamie M. Goodson, Inez Pranoto, Anup Madan, Michael T. Chin, Rong Tian, Charles E. Murry, Randall T. Moon, Yuliang Wang, Hannele Ruohola-Baker
Publikováno v:
iScience
iScience, Vol 25, Iss 1, Pp 103574-(2022)
iScience, Vol 25, Iss 1, Pp 103574-(2022)
Summary Heart disease is the leading cause of death with no method to repair damaged myocardium due to the limited proliferative capacity of adult cardiomyocytes. Curiously, mouse neonates and zebrafish can regenerate their hearts via cardiomyocyte d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4108bee827152af7bb0592dd9e8cb147
http://europepmc.org/articles/PMC8704488
http://europepmc.org/articles/PMC8704488
Publikováno v:
Analytical Chemistry. 91:2464-2471
Coenzyme A (CoA) and acetyl-coenzyme A (acetyl-CoA) are ubiquitous cellular molecules, which mediate hundreds of anabolic and catabolic reactions including energy metabolism. Highly sensitive methods including absorption spectroscopy and mass spectro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6945961a71e00e1e20708bba5e99509
https://doi.org/10.1021/acs.analchem.8b05286
https://doi.org/10.1021/acs.analchem.8b05286
Publikováno v:
Diabetes. 68
The rate limiting step of BCAA (Branched-chain amino acid; Valine, Leucine and Isoleucine) catabolism is regulated by the branched-chain keto acid dehydrogenase complex (BCKDC). PPM1K is a phosphatase which regulates BCAA catabolism by activating BCK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8035d52e2fead655e49e77ef4a76143
https://doi.org/10.2337/db19-1921-p
https://doi.org/10.2337/db19-1921-p
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Leigh syndrome is a mitochondrial disease characterized by neurological disorders, metabolic abnormality and premature death. There is no cure for Leigh syndrome; therefore, new therapeutic targets are urgently needed. In Ndufs4-KO mice, a mouse mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b939190625f1563e1dab0189cc42dac
https://doi.org/10.1038/s41598-019-39419-4
https://doi.org/10.1038/s41598-019-39419-4
Autor:
Lauren Abell, Robert H. Pierce, Jean S. Campbell, Timothy Panella, Dhaval Shah, Ramzi Melhem, Dong M. Shin, William Cairns Stewart Smith, John Celebi, Marie-Louise Fjaellskog, Ann Wild Gramza, Justine Yang Bruce, Alain Algazi
Publikováno v:
Journal of Clinical Oncology. 39:6029-6029
6029 Background: The absence of infiltrating antigen-specific CD8+ T-cells at baseline is associated with low response rates to PD-1 blockade. SCCHN tumors often exclude effector T cells, and 2nd line response rates are low (13-18%). Highly immunogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71d3ef4babc3c263c970f0b047d69f16
https://doi.org/10.1200/jco.2021.39.15_suppl.6029
https://doi.org/10.1200/jco.2021.39.15_suppl.6029
Publikováno v:
Analytical Chemistry
Coenzymes of cellular redox reactions and cellular energy mediate biochemical reactions fundamental to the functioning of all living cells. Despite their immense interest, no simple method exists to gain insights into their cellular concentrations in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc5841ed99b4db640e5e3486c89d4605
https://doi.org/10.1021/acs.analchem.6b00442
https://doi.org/10.1021/acs.analchem.6b00442