Výsledky vyhledávání - "Lauren A. Licata"

Liver myeloid-derived suppressor cells expand in response to liver metastases in mice and inhibit the anti-tumor efficacy of anti-CEA CAR-T

Autor: Alfred Ayala, Prajna Guha, Cang T. Nguyen, Gary Point, Ronald P. DeMatteo, Richard P. Junghans, Mitchell Thorn, Rachel A. Burga, Lauren A. Licata, Steven C. Katz, N. Joseph Espat

Publikováno v: Cancer Immunology, Immunotherapy. 64:817-829

Chimeric antigen receptor-modified T cell (CAR-T) technology, a promising immunotherapeutic tool, has not been applied specifically to treat liver metastases (LM). While CAR-T delivery to LM can be optimized by regional intrahepatic infusion, we prop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12baf2f508acd2dd8cc54629732b3db4
https://doi.org/10.1007/s00262-015-1692-6

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Neutrophil:lymphocyte ratios and serum cytokine changes after hepatic artery chimeric antigen receptor-modified T-cell infusions for liver metastases

Autor: Mitchell Thorn, Robin Davies, Brian F. Stainken, Abdul Saied, Elise McCormack, Richard P. Junghans, E O Assanah, Lauren A. Licata, N J Espat, Steven C. Katz, Rachel A. Burga, P D Khare

Publikováno v: Cancer gene therapy

Our phase I Hepatic Immunotherapy for Metastases (HITM) trial tested the safety of chimeric antigen receptor-modified T-cell (CAR-T) hepatic artery infusions (HAI) for unresectable carcinoembryonic antigen (CEA)+ liver metastases (LM). High neutrophi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fe78db5b22a9ca2e8717f8b2937eaf2
https://doi.org/10.1038/cgt.2014.50

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Biliary obstruction results in PD-1-dependent liver T cell dysfunction and acute inflammation mediated by Th17 cells and neutrophils

Autor: Lauren A. Licata, Alfred Ayala, Steven C. Katz, N. Joseph Espat, Richard P. Junghans, Cang T. Nguyen, Mitchell Thorn, Rachel A. Burga, Vincent Falanga

Publikováno v: Journal of leukocyte biology. 94(4)

Biliary obstruction is a common clinical problem that is associated with intrahepatic inflammation and impaired immunity. PD-1 is well known to mediate T cell dysfunction but has been reported to promote and attenuate acute inflammation in various in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94720077ff2641019f043b95cdecbc86
https://pubmed.ncbi.nlm.nih.gov/23883516

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The RNA-binding protein HuR regulates GATA3 mRNA stability in human breast cancer cell lines

Autor: James Crismale, Christine L. Hostetter, Lauren A. Licata, Judith Clancy Keen, Anjali Sheth

Publikováno v: Breast cancer research and treatment. 122(1)

Meta-analyses of microarray data indicate that GATA3 is co-expressed with estrogen receptor alpha (ER) in breast cancer cells. While the significance of this remains unclear, it is thought that GATA3 may serve as a prognostic indicator in breast tumo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54d831408e9058acbefb6927ef1f92f1
https://pubmed.ncbi.nlm.nih.gov/19728080

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Timing is everything: order of administration of 5-aza 2' deoxycytidine, trichostatin A and tamoxifen changes estrogen receptor mRNA expression and cell sensitivity

Autor: Christine L. Hostetter, Lauren A. Licata, Judith Clancy Keen

Publikováno v: Cancer letters. 275(2)

Restoration of estrogen receptor (ER) expression using epigenetic inhibitors re-establishes expression of the estrogen receptor (ER) and restores tamoxifen sensitivity in ER negative breast cancer cells. We tested if order of administration of the DN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82addb5e19811ba9cf3866c379d57e1c
https://pubmed.ncbi.nlm.nih.gov/19013015

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Targeting myeloid-derived suppressor cells and the PD-1/PD-L1 axis to enhance immunotherapy with anti-CEA designer T cells for the treatment of colorectal liver metastases

Autor: Lauren A. Licata, Mitchell Thorn, Cang T. Nguyen, Richard P. Junghans, Rachel A. Burga, Steven C. Katz, N. Joseph Espat

Publikováno v: Journal of Clinical Oncology. 31:3079-3079

3079 Background: Immunotherapy for colorectal cancer liver metastases (CRCLM) is limited by the intrahepatic immunosuppressive environment mediated in part by myeloid derived suppressor cells (MDSC), which expand in response to tumor. T cell suppress

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1dd824599b4cdd1d601ac40c2dcc66d
https://doi.org/10.1200/jco.2013.31.15_suppl.3079

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A role for GATA-3 in control of estrogen receptor alpha expression

Autor: Judith Clancy Keen, Lauren A. Licata, Christine L. Hostetter

Publikováno v: Cancer Research. 69:3050

Abstract #3050 Expression of the GATA-3 binding protein correlates with estrogen receptor (ER) alpha expression in primary and cultured breast cancer cells. While the significance of this correlation and role of GATA-3 in breast cancer remains unclea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::031e03d4af89b10348e51941c5f239aa
https://doi.org/10.1158/0008-5472.sabcs-3050

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