Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Lauren A Webster"'
Autor:
Maikel Izquierdo, De Lin, Sandra O'Neill, Lauren A Webster, Christy Paterson, John Thomas, Mirtha Elisa Aguado, Enrique Colina Araújo, Daniel Alpízar-Pedraza, Halimatu Joji, Lorna MacLean, Anthony Hope, David W Gray, Martin Zoltner, Mark C Field, Jorge González-Bacerio, Manu De Rycker
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 18, Iss 2, p e0011956 (2024)
BackgroundChagas disease is caused by the protozoan parasite Trypanosoma cruzi and leads to ~10,000 deaths each year. Nifurtimox and benznidazole are the only two drugs available but have significant adverse effects and limited efficacy. New chemothe
Externí odkaz:
https://doaj.org/article/eda16b548238447697b8e6f336b5e1ca
Autor:
Martin Zoltner, De Lin, Jorge González-Bacerio, Maikel Izquierdo, David W. Gray, Sandra O’Neill, Anthony G. Hope, Mark C. Field, Lauren A. Webster
Publikováno v:
SLAS Discovery. 25:1064-1071
Leucyl aminopeptidases (LAPs) are involved in multiple cellular functions, which, in the case of infectious diseases, includes participation in the pathogen-host cell interface and pathogenesis. Th...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eceb2b5a0317f60fc45a0134195e74ad
https://doi.org/10.1177/2472555220923367
https://doi.org/10.1177/2472555220923367
Autor:
Benson R Kidenya, Rodrick Kabangila, Robert N Peck, Stephen E Mshana, Lauren E Webster, Serena P Koenig, Warren D Johnson, Daniel W Fitzgerald
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57527 (2013)
Early, efficient and inexpensive methods for the detection of pulmonary tuberculosis are urgently needed for effective patient management as well as to interrupt transmission. These methods to detect M. tuberculosis in a timely and affordable way are
Externí odkaz:
https://doaj.org/article/27a01d3b075c4ac99b9d060a2bbb0211
Autor:
Lauren E. Webster, Lorraine L. Lipscombe, Karen Tu, Baiju R. Shah, Jeremiah Hwee, Gillian L. Booth
Publikováno v:
BMC Health Services Research, Vol 18, Iss 1, Pp 1-8 (2018)
BMC Health Services Research
BMC Health Services Research
Background Health care data allow for the study and surveillance of chronic diseases such as diabetes. The objective of this study was to identify and validate optimal algorithms for diabetes cases within health care administrative databases for diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d65cf4195c4e66d67ae3dd09b48c24c
http://link.springer.com/article/10.1186/s12913-018-3148-0
http://link.springer.com/article/10.1186/s12913-018-3148-0
Autor:
Jennifer Riley, Borvornwat Toviwek, Kevin D. Read, Adchatawut Konsue, Lauren A. Webster, Oraphan Phuangsawai, Irene Hallyburton, Supa Hannongbua, Nicole Mutter, Mark G. Anderson, M. Paul Gleeson
Publikováno v:
Bioorganic & Medicinal Chemistry. 46:116348
Twenty eight new N2,N4-diphenylpyrimidine-2,4-diamines have been prepared in order to expand our understanding of the anti-malarial SAR of the scaffold. The aim of the study was to make structural modifications to improve the overall potency, selecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9626e7cf48b864ec65e99cac4298ff0d
https://doi.org/10.1016/j.bmc.2021.116348
https://doi.org/10.1016/j.bmc.2021.116348
Autor:
Lauren A, Webster, Michael, Thomas, Michael, Urbaniak, Susan, Wyllie, Han, Ong, Michele, Tinti, Alan H, Fairlamb, Markus, Boesche, Sonja, Ghidelli-Disse, Gerard, Drewes, Ian H, Gilbert
Publikováno v:
ACS Infectious Diseases
The folate pathway has been extensively studied in a number of organisms, with its essentiality exploited by a number of drugs. However, there has been little success in developing drugs that target folate metabolism in the kinetoplastids. Despite co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::78ccb1d13703749f6a7d708822ac42ce
https://pubmed.ncbi.nlm.nih.gov/30264983
https://pubmed.ncbi.nlm.nih.gov/30264983
Autor:
Benson R. Kidenya, Daniel W. Fitzgerald, Robert N. Peck, Rodrick Kabangila, Stephen E. Mshana, Lauren E. Webster, Sehan Behan, Oksana Ocheretina
Publikováno v:
Tuberculosis. 94:1-7
Multidrug-resistant tuberculosis (MDR-TB) is an emerging problem in many parts of the world, and levels of MDR-TB among new TB patients are increasing in sub-Saharan Africa. We reviewed the prevalence and molecular epidemiology of MDR-TB in East Afri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bb70ea5ff77c9047d6e5e26fd38c649
https://doi.org/10.1016/j.tube.2013.08.009
https://doi.org/10.1016/j.tube.2013.08.009
Publikováno v:
Journal of Investigative Dermatology. 139:2252-2257.e1
This article aims to provide an overview of drug discovery with a focus on application within dermatology. The term "drug" can be used to describe a wide variety of agents, including small molecules, cell therapies, and antibodies, which may be dosed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5144c1dea38f2433573938dded92de0
https://doi.org/10.1016/j.jid.2019.07.699
https://doi.org/10.1016/j.jid.2019.07.699
Autor:
John Farris, Naomi J. Aldrich, Lauren M. Webster, Lisa K. Kenyon, Lyndsay Hammond, Cailee Gallagher
Publikováno v:
Physicaloccupational therapy in pediatrics. 37(1)
Young children with neurodevelopmental conditions are often limited in their ability to explore and learn from their environment. The purposes of this case series were to (1) describe the outcomes of using an alternative power mobility device with yo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a809fbc9759ea270c9324d3aed30e0ce
https://pubmed.ncbi.nlm.nih.gov/26735082
https://pubmed.ncbi.nlm.nih.gov/26735082
Publikováno v:
Tetrahedron Letters
Graphical abstract
We report the extension of the copper(II) tetrafluoroborate catalysed opening of epoxides with alcohols to include a wider variety of alcohols, a range of solvents and a method to purify the products from the reaction.
We report the extension of the copper(II) tetrafluoroborate catalysed opening of epoxides with alcohols to include a wider variety of alcohols, a range of solvents and a method to purify the products from the reaction.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28b998c1764f63afff36615dcd735d7d
https://doi.org/10.1016/j.tetlet.2011.10.090
https://doi.org/10.1016/j.tetlet.2011.10.090