Non-invasive imaging reveals conditions that impact distribution and persistence of cells after in vivo administration

Autor: Lauren Scarfe, Arthur Taylor, Jack Sharkey, Rachel Harwood, Michael Barrow, Joan Comenge, Lydia Beeken, Cai Astley, Ilaria Santeramo, Claire Hutchinson, Lorenzo Ressel, Jon Smythe, Eric Austin, Raphael Levy, Matthew J. Rosseinsky, Dave J. Adams, Harish Poptani, Brian K. Park, Patricia Murray, Bettina Wilm

Publikováno v: Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-17 (2018)

Abstract Background Cell-based regenerative medicine therapies are now frequently tested in clinical trials. In many conditions, cell therapies are administered systemically, but there is little understanding of their fate, and adverse events are oft

Externí odkaz: https://doaj.org/article/90b861852cd94ace8b91583c61cbdcce

Cell-free hemoglobin augments acute kidney injury during experimental sepsis

Autor: Nataliya I. Skrypnyk, Jamie L. Kuck, Julie A. Bastarache, Fiona E. Harrison, Ciara M. Shaver, Haichun Yang, Lorraine B. Ware, Melinda G. Paul, Lauren Scarfe, Nathan D. Putz, Mark P. de Caestecker, Stuart R. Landstreet

Publikováno v: Am J Physiol Renal Physiol

Acute kidney injury is a common complication of severe sepsis and contributes to high mortality. The molecular mechanisms of acute kidney injury during sepsis are not fully understood. Because hemoproteins, including myoglobin and hemoglobin, are kno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0093f1abc08152624add27f9bd4cc5d
https://doi.org/10.1152/ajprenal.00375.2018

Non-invasive imaging reveals conditions that impact distribution and persistence of cells after in vivo administration

Autor: Eric Austin, Jon Smythe, Brian Kevin Park, Jack Sharkey, Harish Poptani, Patricia Murray, Joan Comenge, Michael Barrow, Dave J. Adams, Raphaël Lévy, Cai Astley, Bettina Wilm, Rachel Harwood, Ilaria Santeramo, Arthur Taylor, Claire Hutchinson, Lydia Beeken, Lauren Scarfe, Lorenzo Ressel, Matthew J. Rosseinsky

Publikováno v: Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-17 (2018)
STEM CELL RESEARCH & THERAPY
Stem Cell Research and Therapy
Stem Cell Research & Therapy

BackgroundCell-based regenerative medicine therapies are now frequently tested in clinical trials. In many conditions, cell therapies are administered systemically, but there is little understanding of their fate, and adverse events are often under-r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::423f44298678aa2efedc7ec4b27b94e4
http://link.springer.com/article/10.1186/s13287-018-1076-x

Multimodal Imaging Techniques Show Differences in Homing Capacity Between Mesenchymal Stromal Cells and Macrophages in Mouse Renal Injury Models

Autor: Michael Barrow, Patricia Murray, Bettina Wilm, Dave J. Adams, Matthew J. Rosseinsky, Arthur Taylor, Lauren Scarfe, Jack Sharkey, Rachel Harwood

Publikováno v: Molecular Imaging and Biology
MOLECULAR IMAGING AND BIOLOGY

PurposeThe question of whether mesenchymal stromal cells (MSCs) home to injured kidneys remains a contested issue. To try and understand the basis for contradictory findings reported in the literature, our purpose here was to investigate whether MSC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ed50c8ffc7bc08f6b5c20bca3f136f
https://pubmed.ncbi.nlm.nih.gov/31823201

Long-term outcomes in mouse models of ischemia-reperfusion-induced acute kidney injury

Autor: Emily Newton, Anna Menshikh, Rachel Delgado, Yuantee Zhu, Lauren Scarfe, Mark P. de Caestecker, Charlene Finney

Publikováno v: Am J Physiol Renal Physiol

Severe acute kidney injury has a high mortality and is a risk factor for progressive chronic kidney disease. None of the potential therapies that have been identified in preclinical studies have successfully improved clinical outcomes. This failure i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::913fa6ffe4b0b6b39fed92740a986503
https://europepmc.org/articles/PMC7132317/