Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Lauren, Dong"'
Autor:
Jedd D Wolchok, Taha Merghoub, Sadna Budhu, Roberta Zappasodi, Svena Verma, Inna Serganova, Lauren Dong, Levi Mark Mangarin, Yacine Marouf, Jonathan F Khan
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/f5d34c96234c445483351b5b93532dde
Autor:
Arnab Ghosh, Judith Michels, Riccardo Mezzadra, Divya Venkatesh, Lauren Dong, Ricardo Gomez, Fadi Samaan, Yu-Jui Ho, Luis Felipe Campesato, Levi Mangarin, John Fak, Nathan Suek, Aliya Holland, Cailian Liu, Mohsen Abu-Akeel, Yonina Bykov, Hong Zhong, Kelly Fitzgerald, Sadna Budhu, Andrew Chow, Roberta Zappasodi, Katherine S. Panageas, Olivier de Henau, Marcus Ruscetti, Scott W. Lowe, Taha Merghoub, Jedd D. Wolchok
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 18 (2022)
In addition to playing a major role in tumor cell biology, p53 generates a microenvironment that promotes antitumor immune surveillance via tumor-associated macrophages. We examined whether increasing p53 signaling in the tumor microenvironment influ
Externí odkaz:
https://doaj.org/article/4dd0c33291a24e69965b3018d2f98727
604 Combining a novel dual RAF/MEK inhibitor with immunomodulation to promote an anti-tumor response
Autor:
Taha Merghoub, Sadna Budhu, Isabell Schulze, Lauren Dong, Hyejin Choi, Nezar Mehanna, Neal Rosen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/376cfb883ec94324900c5cfe2123a4cc
Publikováno v:
Journal of Clinical and Translational Science, Vol 5, Pp 138-139 (2021)
ABSTRACT IMPACT: Our data identify a novel candidate for combination strategy in melanoma treatment, and can inform clinicians in their decision-making process regarding therapeutic intervention for melanoma patients. OBJECTIVES/GOALS: Soluble adenyl
Externí odkaz:
https://doaj.org/article/25a50077063b45b595600a4d55a43367
Autor:
Hyejin Choi, Jiehui Deng, Shuai Li, Tarik Silk, Lauren Dong, Elliott J. Brea, Sean Houghton, David Redmond, Hong Zhong, Jonathan Boiarsky, Esra A. Akbay, Paul D. Smith, Taha Merghoub, Kwok-Kin Wong, Jedd D. Wolchok
Publikováno v:
Cell Reports, Vol 27, Iss 3, Pp 806-819.e5 (2019)
Summary: KRAS is one of the driver oncogenes in non-small-cell lung cancer (NSCLC) but remains refractory to current modalities of targeted pathway inhibition, which include inhibiting downstream kinase MEK to circumvent KRAS activation. Here, we sho
Externí odkaz:
https://doaj.org/article/efa987c04f3a452490755f945bd7a287
Autor:
Jonathan Khan, Winson Cai, Yanhong Yang, Lauren Dong, Kelsey Hopland, Kenny Kwok-Hei Yu, Ruby Freeman, Terence Purdon, Viviane Tabar, Taha Merghoub, Jedd Wolchok, Renier Brentjens
Publikováno v:
Regular and Young Investigator Award Abstracts.
Autor:
Svena Verma, Inna Serganova, Lauren Dong, Sadna Budhu, Levi Mangarin, Roberta Zappasodi, Taha Merghoub, Jedd D. Wolchok
Publikováno v:
Cancer Research. 83:5873-5873
Tumor reliance on glycolysis is a hallmark of cancer and a mechanism of resistance to immunotherapy. This resistance is due to lactate-mediated immune suppression and competition for glucose between T cells and tumor cells within the tumor microenvir
Autor:
Svena Verma, Inna Serganova, Sadna Budhu, Lauren Dong, Myat Ko, Levi Mangarin, Taha Merghoub, Jedd Wolchok, Roberta Zappasodi
Publikováno v:
Cancer Research. 82:3537-3537
Preferential engagement in glycolysis is a hallmark of cancer cells and contributes to the progression and metastasis of many tumor types, including melanoma and triple-negative breast cancer (TNBC). Tumor reliance on glycolysis is emerging as a mech
Autor:
Arnab Ghosh, Judith Michel, Divya Venkatesh, Riccardo Mezzadra, Lauren Dong, Fadi Samaan, Ricardo Gomez, Nathan Suek, Aliya Holland, Yu-Jui Ho, Mohsen Abu-Akeel, Luis Felipe Campesato, Levi Mark Bala Mangarin, Cailian Liu, Hong Zhong, Sadna Budhu, Andrew Chow, Roberta Zappasodi, Marcus Ruscetti, Scott W. Lowe, Taha Merghoub, Jedd D. Wolchok
Publikováno v:
Cancer Research. 82:250-250
Canonical p53-activated pathways can influence a microenvironment that promotes antitumor immune surveillance via tumor-associated macrophages (TAMs). We examined whether p53 activity in the tumor microenvironment (TME) influences antitumor immunity
Autor:
Lauren Dong, Hyejin Choi, Sadna Budhu, Isabell Schulze, Svena Verma, Nezar Mehanna, Neal Rosen, Taha Merghoub, Jedd Wolchok
Publikováno v:
Cancer Research. 82:4175-4175
To enhance the therapeutic scope of MEK inhibitors (MEKis), we aim to develop new strategies to extend their usage to MEKi resistant RAS mutant cancers, which represent an unmet clinical need. CH5126766 (CKI27) binds the allosteric site of MEK to inh