Výsledky vyhledávání - "Laureline Roger"

Akademický článek

T cell memory revisited using single telomere length analysis

Autor: Laureline Roger, Kelly L. Miners, Louise Leonard, Julia W. Grimstead, David A. Price, Duncan M. Baird, Kristin Ladell

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

The fundamental basis of T cell memory remains elusive. It is established that antigen stimulation drives clonal proliferation and differentiation, but the relationship between cellular phenotype, replicative history, and longevity, which is likely e

Externí odkaz: https://doaj.org/article/9fd079d5624c4d788d97c445966b751e

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Akademický článek

CD57+ Memory T Cells Proliferate In Vivo

Autor: Raya Ahmed, Kelly L. Miners, Julio Lahoz-Beneytez, Rhiannon E. Jones, Laureline Roger, Christina Baboonian, Yan Zhang, Eddie C.Y. Wang, Marc K. Hellerstein, Joseph M. McCune, Duncan M. Baird, David A. Price, Derek C. Macallan, Becca Asquith, Kristin Ladell

Publikováno v: Cell Reports, Vol 33, Iss 11, Pp 108501- (2020)

Summary: A central paradigm in the field of lymphocyte biology asserts that replicatively senescent memory T cells express the carbohydrate epitope CD57. These cells nonetheless accumulate with age and expand numerically in response to persistent ant

Externí odkaz: https://doaj.org/article/7885536d2b5e42149b0d76509a9181e5

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Akademický článek

Human TSCM cell dynamics in vivo are compatible with long-lived immunological memory and stemness.

Autor: Pedro Costa Del Amo, Julio Lahoz-Beneytez, Lies Boelen, Raya Ahmed, Kelly L Miners, Yan Zhang, Laureline Roger, Rhiannon E Jones, Silvia A Fuertes Marraco, Daniel E Speiser, Duncan M Baird, David A Price, Kristin Ladell, Derek Macallan, Becca Asquith

Publikováno v: PLoS Biology, Vol 16, Iss 6, p e2005523 (2018)

Adaptive immunity relies on the generation and maintenance of memory T cells to provide protection against repeated antigen exposure. It has been hypothesised that a self-renewing population of T cells, named stem cell-like memory T (TSCM) cells, are

Externí odkaz: https://doaj.org/article/c85bfaa7e2db4200835697b9df1f03c9

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Akademický článek

Escape from Telomere-Driven Crisis Is DNA Ligase III Dependent

Autor: Rhiannon E. Jones, Sehyun Oh, Julia W. Grimstead, Jacob Zimbric, Laureline Roger, Nicole H. Heppel, Kevin E. Ashelford, Kate Liddiard, Eric A. Hendrickson, Duncan M. Baird

Publikováno v: Cell Reports, Vol 8, Iss 4, Pp 1063-1076 (2014)

Short dysfunctional telomeres are capable of fusion, generating dicentric chromosomes and initiating breakage-fusion-bridge cycles. Cells that escape the ensuing cellular crisis exhibit large-scale genomic rearrangements that drive clonal evolution a

Externí odkaz: https://doaj.org/article/74ca282653444cada7d066278696395b

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Akademický článek

Cooperative anti-invasive effect of Cdc42/Rac1 activation and ROCK inhibition in SW620 colorectal cancer cells with elevated blebbing activity.

Autor: Marion de Toledo, Christelle Anguille, Laureline Roger, Pierre Roux, Gilles Gadea

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e48344 (2012)

Rho GTPases are key regulators of tumour cell invasion and therefore constitute attractive targets for the design of anticancer agents. Several strategies have been developed to modulate their increased activities during cancer progression. Interesti

Externí odkaz: https://doaj.org/article/4a22ecc5d5f54901a9c638ef4052a19e

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Akademický článek

Blood cell telomere length is a dynamic feature.

Autor: Ulrika Svenson, Katarina Nordfjäll, Duncan Baird, Laureline Roger, Pia Osterman, Mai-Lis Hellenius, Göran Roos

Publikováno v: PLoS ONE, Vol 6, Iss 6, p e21485 (2011)

There is a considerable heterogeneity in blood cell telomere length (TL) for individuals of similar age and recent studies have revealed that TL changes by time are dependent on TL at baseline. TL is partly inherited, but results from several studies

Externí odkaz: https://doaj.org/article/0ef5223d771a4663863a8f16c240a732

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CD57+ Memory T Cells Proliferate In Vivo

Autor: Becca Asquith, Rhiannon E. Jones, Kristin Ladell, Yan Zhang, Julio Lahoz-Beneytez, Laureline Roger, Raya Ahmed, Derek C. Macallan, Edward Chung Yern Wang, Duncan M. Baird, Kelly L. Miners, Joseph M. McCune, Christina Baboonian, Marc K. Hellerstein, David Price

Publikováno v: Cell Reports
Cell Reports, Elsevier Inc, 2020, 33 (11), pp.108501. ⟨10.1016/j.celrep.2020.108501⟩
Cell Reports, Vol 33, Iss 11, Pp 108501-(2020)
e5
e1

Summary A central paradigm in the field of lymphocyte biology asserts that replicatively senescent memory T cells express the carbohydrate epitope CD57. These cells nonetheless accumulate with age and expand numerically in response to persistent anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019bd1176b8dcb79c13d493b4d25cfba
https://hal.archives-ouvertes.fr/hal-03204476

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Human TSCM cell dynamics in vivo are compatible with long-lived immunological memory and stemness

Autor: Julio Lahoz-Beneytez, Kristin Ladell, Duncan M. Baird, Rhiannon E. Jones, Yan Zhang, Lies Boelen, Daniel E. Speiser, Becca Asquith, Laureline Roger, Silvia A. Fuertes Marraco, Kelly L. Miners, David Price, Derek C. Macallan, Raya Ahmed, Pedro Costa del Amo

Publikováno v: PLoS Biology, Vol 16, Iss 6, p e2005523 (2018)
PLoS Biology
PLoS Biology, Public Library of Science, 2018, 16 (6), pp.e2005523. ⟨10.1371/journal.pbio.2005523⟩

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba97db7aa0bbf06b267a2f573533b52
http://europepmc.org/articles/PMC6033534?pdf=render

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Telomere length profiles in primary human peritoneal mesothelial cells are consistent with senescence

Autor: Duncan M. Baird, Andras Rudolf, Rhiannon E. Jones, Donald James Fraser, Timothy Bowen, Melisa Lopez-Anton, Laureline Roger, Janusz Witowski

Publikováno v: Mechanisms of Ageing and Development
Mechanisms of Ageing and Development, Elsevier, 2017, 164, pp.37-40. ⟨10.1016/j.mad.2017.03.010⟩
Mechanisms of Ageing and Development, 2017, 164, pp.37-40. ⟨10.1016/j.mad.2017.03.010⟩

Mesothelial cell (MC) senescence contributes to malignancy and tissue fibrosis. The\ud role of telomere erosion in MC senescence remains controversial, with evidence for\ud both telomere-dependent and telomere-independent mechanisms reported. Single\

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25fe28e03fe9ebb73991380800543f95
https://hal.archives-ouvertes.fr/hal-03204489

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Reproducibility of telomere length assessment: an international collaborative study

Publikováno v: International Journal of Epidemiology
International Journal of Epidemiology, Oxford University Press (OUP), 2015, 44 (5), pp.1673-1683. ⟨10.1093/ije/dyu191⟩
International Journal of Epidemiology, 44(5), 1673-1683. Oxford University Press
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
International Journal of Epidemiology, Oxford University Press (OUP), 2015, 44 (5), pp.1749-1754. ⟨10.1093/ije/dyv171⟩
International Journal of Epidemiology, 2015, 44 (5), pp.1673-1683. ⟨10.1093/ije/dyu191⟩
International Journal of Epidemiology, 2015, 44 (5), pp.1749-1754. ⟨10.1093/ije/dyv171⟩

Background: Telomere length is a putative biomarker of ageing, morbidity and mortality. Its application is hampered by lack of widely applicable reference ranges and uncertainty regarding the present limits of measurement reproducibility within and b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97e1d407941b583151ede2d144ea393f
http://europepmc.org/articles/PMC4681105

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