Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Laurel S. Kleppe"'
Autor:
Claudia F. Lucchinetti, Chan Il Choi, Hyesook Yoon, Monica R. Langley, Isobel A. Scarisbrick, Laurel S. Kleppe, Whitney L. Simon, Claudia C.S. Chini, Eduardo N. Chini, Yong Guo, Thais Peclat
Publikováno v:
The Journal of Neuroscience. 41:8644-8667
Western-style diets cause disruptions in myelinating cells and astrocytes within the mouse CNS. Increased CD38 expression is present in the cuprizone and experimental autoimmune encephalomyelitis models of demyelination and CD38 is the main nicotinam
Autor:
Whitney L. Simon, Elena De Vita, Aubry K. Miller, Erin M. Triplet, Isobel A. Scarisbrick, Chan Il Choi, Hyesook Yoon, Laurel S. Kleppe
Publikováno v:
Glia
Kallikrein related peptidase 6 (Klk6) is a secreted serine protease highly expressed in oligodendrocytes and implicated in demyelinating conditions. To gain insights into the significance of Klk6 to oligodendrocyte biology, we investigated the impact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb6358ef97af4b3fea36da9e948704ab
https://europepmc.org/articles/PMC8732303/
https://europepmc.org/articles/PMC8732303/
Autor:
Shuchong Pan, Horng H Chen, Cristina Correia, Haiming Dai, Tyra A Witt, Laurel S Kleppe, John C Burnett, Robert D Simari
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112986 (2014)
The family of natriuretic peptides (NPs), including atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), exert important and diverse actions for cardiovascular and renal homeostasis. The autocrine
Externí odkaz:
https://doaj.org/article/40303679b20d4262b8eacfc91da7ef2f
Autor:
Chan-Il Choi, Thais Peclat, Monica R. Langley, Whitney L. Simon, Laurel S. Kleppe, Hyesook Yoon, Claudia C.S. Chini, Eduardo N. Chini, Yong Guo, Claudia F. Lucchinetti, Isobel A. Scarisbrick
Western-style diets cause disruptions in myelinating cells and astrocytes within the mouse CNS. CD38 has increased expression in the cuprizone and EAE demyelination models and is the main NAD+ depleting enzyme in CNS tissue. Altered NAD+ metabolism h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cb7156efd1556bc2f167c7e993bdf33
https://doi.org/10.1101/2020.06.10.143941
https://doi.org/10.1101/2020.06.10.143941
Autor:
Isobel A. Scarisbrick, Whitney L. Simon, Monica R. Langley, Laurel S. Kleppe, Erin M. Triplet, Chan Il Choi, Hyesook Yoon, Ha Neui Kim
Publikováno v:
J Neurosci
Myelin loss limits neurological recovery and myelin regeneration and is critical for restoration of function. We recently discovered that global knock-out of the thrombin receptor, also known as Protease Activated Receptor 1 (PAR1), accelerates myeli
Publikováno v:
The FASEB Journal. 33
Autor:
Whitney L. Simon, Maja Radulovic, Isobel A. Scarisbrick, Laurel S. Kleppe, Patrick J. Walsh, Chan Il Choi, Hyesook Yoon, Erin M. Triplet, Ha Neui Kim, James R. Dutton
Publikováno v:
Neurobiology of disease
Neurobiology of Disease, Vol 152, Iss, Pp 105294-(2021)
Neurobiology of Disease, Vol 152, Iss, Pp 105294-(2021)
Despite concerted efforts to identify CNS regeneration strategies, an incomplete understanding of how the needed molecular machinery is regulated limits progress. Here we use models of lateral compression and FEJOTA clip contusion-compression spinal
Autor:
Isobel A. Scarisbrick, Andrew Kleven, Laurel S. Kleppe, Alex R. Paulsen, Zhe Ying, Jianmin Wu, Fernando Gomez-Pinilla, Hyesook Yoon
Publikováno v:
Biochimica et biophysica acta, vol 1862, iss 4
Here we show that the interplay between exercise training and dietary fat regulates myelinogenesis in the adult central nervous system. Mice consuming high fat with coordinate voluntary running wheel exercise for 7 weeks showed increases in the abund
Autor:
Monica R. Langley, Whitney L. Simon, Hyesook Yoon, Isobel A. Scarisbrick, Aleksey V. Matveyenko, Nathan K. LeBrasseur, Ha Neui Kim, Ian R. Lanza, Laurel S. Kleppe
Publikováno v:
Neurobiology of disease
Neurobiology of Disease, Vol 141, Iss, Pp 104934-(2020)
Neurobiology of Disease, Vol 141, Iss, Pp 104934-(2020)
A diet high in fat and sucrose (HFHS), the so-called Western diet promotes metabolic syndrome, a significant co-morbidity for individuals with spinal cord injury (SCI). Here we demonstrate that the spinal cord of mice consuming HFHS expresses reduced
Autor:
Nathan K. LeBrasseur, Laurel S. Kleppe, Whitney L. Simon, Isobel A. Scarisbrick, Monica R. Langley, Ha Neui Kim, Aleksey V. Matveyenko, Chan Il Choi, Hyesook Yoon, Ian R. Lanza
Publikováno v:
Biochim Biophys Acta Mol Basis Dis
Metabolic syndrome is a key risk factor and co-morbidity in multiple sclerosis (MS) and other neurological conditions, such that a better understanding of how a high fat diet contributes to oligodendrocyte loss and the capacity for myelin regeneratio