Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Laurel M Heckman"'
Autor:
Seungkyu Lee, Sooyeon Jo, Sébastien Talbot, Han-Xiong Bear Zhang, Masakazu Kotoda, Nick A Andrews, Michelino Puopolo, Pin W Liu, Thomas Jacquemont, Maud Pascal, Laurel M Heckman, Aakanksha Jain, Jinbo Lee, Clifford J Woolf, Bruce P Bean
Publikováno v:
eLife, Vol 8 (2019)
Voltage-dependent sodium and calcium channels in pain-initiating nociceptor neurons are attractive targets for new analgesics. We made a permanently charged cationic derivative of an N-type calcium channel-inhibitor. Unlike cationic derivatives of lo
Externí odkaz:
https://doaj.org/article/de64bb25275445b0a3e4407fe3462af5
Publikováno v:
Organic letters. 22(21)
Herein, we demonstrate the on-demand synthesis of chloramine from aqueous ammonia and sodium hypochlorite solutions, and its subsequent utilization as an ambiphilic nitrogen source in continuous-flow synthesis. Despite its advantages in cost and atom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe3ced59c6ec2f8390d0089e96c4318
https://pubmed.ncbi.nlm.nih.gov/33086788
https://pubmed.ncbi.nlm.nih.gov/33086788
Autor:
Masakazu Kotoda, Aakanksha Jain, Michelino Puopolo, Clifford J. Woolf, Nick Andrews, Sooyeon Jo, Thomas Jacquemont, Jinbo Lee, Han-Xiong Bear Zhang, Laurel M. Heckman, Maud Pascal, Sébastien Talbot, Bruce P. Bean, Pin W. Liu, Seungkyu Lee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f248ef109b663ee9e8597550bb1d46d
https://doi.org/10.7554/elife.48118.sa2
https://doi.org/10.7554/elife.48118.sa2
Autor:
Thomas Jacquemont, Masakazu Kotoda, Clifford J. Woolf, Laurel M. Heckman, Nick Andrews, Bruce P. Bean, Seungkyu Lee, Han-Xiong Bear Zhang, Michelino Puopolo, Sooyeon Jo, Sébastien Talbot, Maud Pascal, Aakanksha Jain, Jinbo Lee, Pin W. Liu
Publikováno v:
eLife, Vol 8 (2019)
eLife
eLife
Voltage-dependent sodium and calcium channels in pain-initiating nociceptor neurons are attractive targets for new analgesics. We made a permanently charged cationic derivative of an N-type calcium channel-inhibitor. Unlike cationic derivatives of lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da15a53b3d2fd9e142887faa060738cd
https://elifesciences.org/articles/48118
https://elifesciences.org/articles/48118
Autor:
Brenda C. Shields, Jonathan B. Grimm, Eric R. Schreiter, Laurel M. Heckman, Luke D. Lavis, Mark A. Verdecia, Charles Kim
Publikováno v:
Angewandte Chemie (International Ed. in English)
Photolabile protecting groups (or “photocages”) enable precise spatiotemporal control of chemical functionality and facilitate advanced biological experiments. Extant photocages exhibit a simple input–output relationship, however, where applica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a8ba4d591d739422433908bae4843dd
https://doi.org/10.1002/ange.201602941
https://doi.org/10.1002/ange.201602941
Publikováno v:
Organic letters. 20(11)
Highly functionalized 2-arylindoles were synthesized from 2-alkenylarylisocyanides and arylboronic acids using a simple, inexpensive copper catalyst. The reaction exhibits excellent functional group tolerance for both the arylisocyanide and boronic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc37f338e1dd846e27b5fb715b547782
https://pubmed.ncbi.nlm.nih.gov/29761699
https://pubmed.ncbi.nlm.nih.gov/29761699
Autor:
Laurel M. Heckman, Brian R. Stepp, SonBinh T. Nguyen, Franz M. Geiger, Julianne M. Gibbs-Davis, Faith C. Boman
Publikováno v:
Journal of the American Chemical Society. 131:844-848
We present electronic spectra of single-strand and duplex DNA oligonucleotides covalently attached to fused quartz/aqueous interfaces and demonstrate that a strong nonlinear optical linear dichroism response is obtained when adenine and thymine bases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79eaa3b42b723609c7d1ea8ddf209674
https://doi.org/10.1021/ja808007b
https://doi.org/10.1021/ja808007b
Chemical fluorophores find wide use in biology to detect and visualize different phenomena. A key advantage of small-molecule dyes is the ability to construct compounds where fluorescence is activated by chemical or biochemical processes. Fluorogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e98e7a484c988abd20c6668134b25eb
https://doi.org/10.1016/b978-0-12-386932-6.00001-6
https://doi.org/10.1016/b978-0-12-386932-6.00001-6
Publikováno v:
Progress in molecular biology and translational science. 113
Chemical fluorophores find wide use in biology to detect and visualize different phenomena. A key advantage of small-molecule dyes is the ability to construct compounds where fluorescence is activated by chemical or biochemical processes. Fluorogenic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cc10cc3c93657d02207a5ef954a35c07
https://pubmed.ncbi.nlm.nih.gov/23244787
https://pubmed.ncbi.nlm.nih.gov/23244787
Publikováno v:
The journal of physical chemistry. B. 116(16)
The chiral discrimination ability of amino acid based chiral ionic liquids is studied using chiroptical luminescence techniques. A racemic mixture of dissymmetric europium tris(2,6-pyridinedicarboxylate) complexes are dissolved in five chiral ionic l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c20f94e2cd8cd654480a2498bf69969
https://pubmed.ncbi.nlm.nih.gov/22462559
https://pubmed.ncbi.nlm.nih.gov/22462559