Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Laurel L Lenz"'
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009531 (2021)
Most individuals who consume foods contaminated with the bacterial pathogen Listeria monocytogenes (Lm) develop mild symptoms, while others are susceptible to life-threatening systemic infections (listeriosis). Although it is known that the risk of s
Externí odkaz:
https://doaj.org/article/68478766fb8d47b3a0c3f729a53e42f0
Publikováno v:
PLoS Pathogens, Vol 13, Iss 5, p e1006388 (2017)
Interferons (IFNs) target macrophages to regulate inflammation and resistance to microbial infections. The type II IFN (IFNγ) acts on a cell surface receptor (IFNGR) to promote gene expression that enhance macrophage inflammatory and anti-microbial
Externí odkaz:
https://doaj.org/article/087c0784087549f19b7becd0d9f37019
Autor:
Sarah E Clark, Holly C Filak, Brandon S Guthrie, Rebecca L Schmidt, Amanda Jamieson, Patricia Merkel, Vijaya Knight, Caroline M Cole, David H Raulet, Laurel L Lenz
Publikováno v:
PLoS Pathogens, Vol 12, Iss 6, p e1005708 (2016)
Natural killer (NK) cells produce interferon (IFN)-γ and thus have been suggested to promote type I immunity during bacterial infections. Yet, Listeria monocytogenes (Lm) and some other pathogens encode proteins that cause increased NK cell activati
Externí odkaz:
https://doaj.org/article/b0cfe5075d0b459682c420c5e453d221
Publikováno v:
Frontiers in Immunology, Vol 6 (2015)
Externí odkaz:
https://doaj.org/article/ae71d5e38eaf4d3c8122de4b840652e4
Publikováno v:
Frontiers in Immunology, Vol 5 (2014)
Externí odkaz:
https://doaj.org/article/f0d83a0668bf47739016458cae2ba76e
Autor:
Laurel L Lenz, Emily M Eshleman
Publikováno v:
Frontiers in Immunology, Vol 5 (2014)
Type I interferons (IFNs) were first described for their ability to protect the host from viral infections and may also have beneficial effects under specific conditions within some bacterial infections. Yet, these pleiotropic cytokines are now known
Externí odkaz:
https://doaj.org/article/93f43e2126164674908446bad16bec83
Autor:
Rebecca L Schmidt, Laurel L Lenz
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45186 (2012)
Inflammasome activation permits processing of interleukins (IL)-1β and 18 and elicits cell death (pyroptosis). Whether these responses are independently licensed or are "hard-wired" consequences of caspase-1 (casp1) activity has not been clear. Here
Externí odkaz:
https://doaj.org/article/02e6d419abd14e099be3524052466c63
Publikováno v:
PLoS Pathogens, Vol 7, Iss 11, p e1002368 (2011)
Listeria monocytogenes (Lm) infection induces rapid and robust activation of host natural killer (NK) cells. Here we define a region of the abundantly secreted Lm endopeptidase, p60, that potently but indirectly stimulates NK cell activation in vitro
Externí odkaz:
https://doaj.org/article/6deccbdc236940c29b6f4b2c9922d95c
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15142 (2010)
Many inflammatory diseases, as well as infections, are accompanied by elevation in cellular levels of Reactive Oxygen Species (ROS). Here we report that MPYS, a.k.a. STING, which was recently shown to mediate activation of IFNβ expression during inf
Externí odkaz:
https://doaj.org/article/e1b9b353ac354eb5aa4402168471d66d