Zobrazeno 1 - 10
of 257
pro vyhledávání: '"Laurel L Lenz"'
Publikováno v:
Current Research in Immunology, Vol 1, Iss , Pp 1-9 (2020)
The type II interferon (IFNγ) promotes resistance to intracellular pathogens. Most immune and somatic cells also express the IFNγ receptor (IFNGR) and respond to IFNγ. While myeloid cell have been implicated as important targets of IFNγ, it remai
Externí odkaz:
https://doaj.org/article/643f591270dc42b6995512ea8816eed7
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009531 (2021)
Most individuals who consume foods contaminated with the bacterial pathogen Listeria monocytogenes (Lm) develop mild symptoms, while others are susceptible to life-threatening systemic infections (listeriosis). Although it is known that the risk of s
Externí odkaz:
https://doaj.org/article/68478766fb8d47b3a0c3f729a53e42f0
Autor:
Sandy R. Larson, Nikki Bortell, Alysha Illies, William J. Crisler, Jennifer L. Matsuda, Laurel L. Lenz
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Kinase activity plays an essential role in the regulation of immune cell defenses against pathogens. The protein kinase CK2 (formerly casein kinase II) is an evolutionarily conserved kinase with hundreds of identified substrates. CK2 is ubiquitously
Externí odkaz:
https://doaj.org/article/2834febe335e496f8b95c25575705ac9
Autor:
Melissa M. Walker, Soojin Kim, William J. Crisler, Kimberlie Nguyen, Laurel L. Lenz, John C. Cambier, Andrew Getahun
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Stimulator of interferon genes (STING) plays a central role in innate immune responses to viral and intracellular bacterial infections, and cellular damage. STING is a cytosolic sensor of cyclic dinucleotides (CDNs) including those produced by pathog
Externí odkaz:
https://doaj.org/article/9c135511f7434450b8fd32851c4ee559
Autor:
Elizabeth R. Aguilera, Laurel L. Lenz
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Bacterial and viral pathogens are predominant causes of pulmonary infections and complications. Morbidity and mortality from these infections is increased in populations that include the elderly, infants, and individuals with genetic disorders such a
Externí odkaz:
https://doaj.org/article/2d2c57858111430f945bc41e68573b30
Autor:
Taylor K. Soderborg, Sarah E. Clark, Christopher E. Mulligan, Rachel C. Janssen, Lyndsey Babcock, Diana Ir, Bridget Young, Nancy Krebs, Dominick J. Lemas, Linda K. Johnson, Tiffany Weir, Laurel L. Lenz, Daniel N. Frank, Teri L. Hernandez, Kristine A. Kuhn, Angelo D’Alessandro, Linda A. Barbour, Karim C. El Kasmi, Jacob E. Friedman
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Infants born to obese mothers have altered microbiome and increased risk of obesity and NAFLD. Here the authors establish causality by showing that maternal obesity-shaped infant gut microbiome induces macrophage dysfunction, inflammation, and diet-i
Externí odkaz:
https://doaj.org/article/ae080f0844c14d709b3a8306cb9877f4
Publikováno v:
Cell Reports, Vol 23, Iss 9, Pp 2582-2594 (2018)
The bacterial pathogen Listeria monocytogenes (Lm) capitalizes on natural killer (NK) cell production of regulatory interleukin (IL)-10 to establish severe systemic infections. Here, we identify regulators of this IL-10 secretion. We show that IL-18
Externí odkaz:
https://doaj.org/article/5349d1cd1c8c49c9b849f6d204db45ee
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Natural killer (NK) cells can produce IFNγ or IL-10 to regulate inflammation and immune responses but the factors driving NK cell IL-10 secretion are poorly-defined. Here, we identified NK cell-intrinsic STAT3 activation as vital for IL-10 productio
Externí odkaz:
https://doaj.org/article/ce1faefa95334bcab085196cd0862de7
Autor:
Jenna M. Vickery, Jody D. Toperzer, Julie E. Raab, Laurel L. Lenz, Sean P. Colgan, Brian C. Russo
For many intracellular pathogens, their virulence depends on an ability to spread between cells of an epithelial layer. For intercellular spread to occur, these pathogens deform the plasma membrane into a protrusion structure that is engulfed by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e5ab9368bca10a7bc375ef112e36dca
https://doi.org/10.1101/2023.04.25.537990
https://doi.org/10.1101/2023.04.25.537990
