Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Laurel Hoffman"'
Autor:
Zhijun Tan, Vivekh Ehamparanathan, Tingwei Ren, Peifeng Tang, Laurel Hoffman, June Kuang, Peiran Liu, Chao Huang, Cheng Du, Li Tao, Letha Chemmalil, Angela Lewandowski, Sanchayita Ghose, Zheng Jian Li, Shijie Liu
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Disulfide bond reduction, which commonly occurs during monoclonal antibody (mAb) manufacturing processes, can result in a drug substance with high levels of low molecular weight (LMW) species that may fail release specifications because the drug’s
Externí odkaz:
https://doaj.org/article/18ea0b2eb9fc414ebf9fd1ddbcf039cb
Autor:
Peifeng Tang, Zhijun Tan, Vivekh Ehamparanathan, Tingwei Ren, Laurel Hoffman, Cheng Du, Yuanli Song, Li Tao, Angela Lewandowski, Sanchayita Ghose, Zheng Jian Li, Shijie Liu
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Disulfide bonds play a crucial role in folding and structural stabilization of monoclonal antibodies (mAbs). Disulfide bond reduction may happen during the mAb manufacturing process, resulting in low molecular weight species and possible failure to m
Externí odkaz:
https://doaj.org/article/c3dc9748a0654796b05a080bcd584973
Autor:
Li Tao, Shijie Liu, Vivekh Ehamparanathan, Cheng Du, Zheng Jian Li, Angela Lewandowski, Laurel Hoffman, Sanchayita Ghose, Yuanli Song, Tingwei Ren, Zhijun Tan, Peifeng Tang
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Disulfide bonds play a crucial role in folding and structural stabilization of monoclonal antibodies (mAbs). Disulfide bond reduction may happen during the mAb manufacturing process, resulting in low molecular weight species and possible failure to m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b85ae209df75c3fd1e664a5e0217843e
https://pubmed.ncbi.nlm.nih.gov/33031716
https://pubmed.ncbi.nlm.nih.gov/33031716
Autor:
Zheng Jian Li, Peiran Liu, Peifeng Tang, Zhijun Tan, June Kuang, Shijie Liu, Letha Chemmalil, Angela Lewandowski, Laurel Hoffman, Li Tao, Sanchayita Ghose, Chao Huang, Vivekh Ehamparanathan, Cheng Du, Tingwei Ren
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Disulfide bond reduction, which commonly occurs during monoclonal antibody (mAb) manufacturing processes, can result in a drug substance with high levels of low molecular weight (LMW) species that may fail release specifications because the drug’s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce482db70c542c34bddf2efa362e2dbb
https://pubmed.ncbi.nlm.nih.gov/33016217
https://pubmed.ncbi.nlm.nih.gov/33016217
Publikováno v:
Biochemistry. 56:2149-2160
Ca2+-calmodulin-dependent protein kinase II (CaMKII) is highly abundant in neurons, where its concentration reaches that typically found for cytoskeletal proteins. Functional reasons for such a high concentration are not known, but given the multitud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc85c1dd92f86ffcfcdef0778ce88374
https://doi.org/10.1021/acs.biochem.7b00028
https://doi.org/10.1021/acs.biochem.7b00028
Autor:
Tapan K. Das, Thomas R. Slaney, Yunping Huang, Sambit R. Kar, Anthony Leone, Gurusamy Balakrishnan, Li Tao, Gregory V. Barnett, Laurel Hoffman, Jacob Bongers, Naresh Chennamsetty
Publikováno v:
Journal of pharmaceutical sciences. 108(6)
Tryptophan (Trp) oxidation in proteins leads to a number of events, including changes in color, higher order structure (HOS), and biological activity. We describe here a number of new findings through a comprehensive characterization of 6 monoclonal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c34f0901eb516236eb163329999787c0
https://pubmed.ncbi.nlm.nih.gov/30639740
https://pubmed.ncbi.nlm.nih.gov/30639740
Publikováno v:
Biophysical Journal. 109(3):510-520
Protein signaling occurs in crowded intracellular environments, and while high concentrations of macromolecules are postulated to modulate protein-protein interactions, analysis of their impact at each step of the reaction pathway has not been system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3076932bf8f931521d29d657b715cf5
Autor:
Margaret S. Cheung, Qian Wang, M. Neal Waxham, Laurel Hoffman, Swarnendu Tripathi, Pengzhi Zhang
Publikováno v:
Journal of Molecular Recognition. 28:74-86
Calmodulin (CaM) is a primary calcium (Ca(2+) )-signaling protein that specifically recognizes and activates highly diverse target proteins. We explored the molecular basis of target recognition of CaM with peptides representing the CaM-binding domai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c15ca8fb4d8e2a4175f09d8a9e02eef6
https://doi.org/10.1002/jmr.2413
https://doi.org/10.1002/jmr.2413
Publikováno v:
Biochemistry. 56(15)
Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::051ad173d1219c8f573e0905c77f326c
https://pubmed.ncbi.nlm.nih.gov/28318265
https://pubmed.ncbi.nlm.nih.gov/28318265
Publikováno v:
Journal of Biological Chemistry. 289:14644-14655
Neurogranin (Ng) is a member of the IQ motif class of calmodulin (CaM)-binding proteins, and interactions with CaM are its only known biological function. In this report we demonstrate that the binding affinity of Ng for CaM is weakened by Ca(2+) but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f8a23964aaf5cea0cb0caf642bf985d
https://doi.org/10.1074/jbc.m114.560656
https://doi.org/10.1074/jbc.m114.560656