Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Laurel Doghramji"'
Autor:
Natalia Goldstein-Daruech, Emily K Cope, Ke-Qing Zhao, Katarina Vukovic, Jennifer M Kofonow, Laurel Doghramji, Bernardo González, Alexander G Chiu, David W Kennedy, James N Palmer, Jeffery G Leid, James L Kreindler, Noam A Cohen
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e15700 (2011)
Cigarette smokers and those exposed to second hand smoke are more susceptible to life threatening infection than non-smokers. While much is known about the devastating effect tobacco exposure has on the human body, less is known about the effect of t
Externí odkaz:
https://doaj.org/article/bbdedc33f8c148bd974b3a6519f23da6
Autor:
Ivy W. Maina, Steven G. Brooks, Alyssa M. Civantos, David W. Kennedy, Noam A. Cohen, Nithin D. Adappa, Laurel Doghramji, Elizabeth M. Stevens, Monique Arnold, Danielle R. Reed, Michael A. Kohanski, Mariel Blasetti, Alan D. Workman, Cailu Lin, James N. Palmer, Beverly J. Cowart, Jennifer E. Douglas, Lauren R. Colquitt, Corrine Mansfield
Publikováno v:
Int Forum Allergy Rhinol
BACKGROUND: Bitter and sweet taste receptors are present in the human upper airway, where they have roles in innate immunity. Previous studies have shown that one of the 25 bitter receptors, TAS2R38, responds to specific bacterial signaling molecules
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e58961a93985b45a4ef7b16a5655d7
https://pubmed.ncbi.nlm.nih.gov/32846055
https://pubmed.ncbi.nlm.nih.gov/32846055
Autor:
Jeremy D. Waldram, Jeff Bulva, Nithin D. Adappa, Laurel Doghramji, John V. Bosso, Andrew A. White, Jordan T. Glicksman, Arjun K. Parasher, David Lawrence Brauer, Kristen M. Walters, James N. Palmer
Publikováno v:
International Forum of Allergy & Rhinology. 8:1093-1097
Background Aspirin-exacerbated respiratory disease (AERD) is characterized by chronic eosinophilic rhinosinusitis, nasal polyps, asthma, and respiratory sensitivity to aspirin and nonsteroidal anti-inflammatory drugs (NSAIDs). In addition to sensitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37d3a6ae1386f691adab2fcac09b6172
https://doi.org/10.1002/alr.22168
https://doi.org/10.1002/alr.22168
Autor:
James N. Palmer, Arjun K. Parasher, Jordan T. Glicksman, Mariel Blasetti, Steven G. Brooks, Laurel Doghramji, Erica R. Thaler, David W. Kennedy, Michal Trope, Nithin D. Adappa, Noam A. Cohen
Publikováno v:
International Forum of Allergy & Rhinology. 8:668-675
Background Disagreement exists about the relationship between Lund-Mackay CT scores (LMCTS) and quality-of-life outcome (QoL) measures. We investigated whether preoperative LMCTS are associated with preoperative QoL, and whether LMCTS is predictive o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db8e8c19f43bf8a702c4c8c313607da4
https://doi.org/10.1002/alr.22109
https://doi.org/10.1002/alr.22109
Autor:
Alan D. Workman, Bei Chen, Ryan M. Carey, David W. Kennedy, Derek B. McMahon, Nithin D. Adappa, Laurel Doghramji, Jenna R. Freund, Robert J. Lee, Benjamin M. Hariri, James N. Palmer, Michael A. Kohanski
Publikováno v:
The FASEB Journal. 32:155-167
Mucociliary clearance, driven by the engine of ciliary beating, is the primary physical airway defense against inhaled pathogens and irritants. A better understanding of the regulation of ciliary beating and mucociliary transport is necessary for ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2665405eb5b67473c46462cbb0f1819c
https://doi.org/10.1096/fj.201700114rrr
https://doi.org/10.1096/fj.201700114rrr
Autor:
David W. Kennedy, Corrine Mansfield, Derek B. McMahon, Nithin D. Adappa, Danielle R. Reed, Benjamin M. Hariri, Robert J. Lee, Jenna R. Freund, Laurel Doghramji, Bei Chen, Peihua Jiang, James N. Palmer
Publikováno v:
Journal of Biological Chemistry. 292:8484-8497
Chronic rhinosinusitis has a significant impact on patient quality of life, creates billions of dollars of annual healthcare costs, and accounts for ∼20% of adult antibiotic prescriptions in the United States. Because of the rise of resistant micro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b7847f6053d8bea7368772ff9c8871f
https://doi.org/10.1074/jbc.m116.771949
https://doi.org/10.1074/jbc.m116.771949
Autor:
Bei Chen, David W. Kennedy, Benjamin M. Hariri, Nithin D. Adappa, Masha Y. Niv, Corrine Mansfield, Sakeena J. Payne, Laurel Doghramji, Robert J. Lee, James N. Palmer
Publikováno v:
American Journal of Rhinology & Allergy. 30:261-268
Background T2R bitter taste receptors play a crucial role in sinonasal innate immunity by upregulating mucociliary clearance and nitric oxide (NO) production in response to bitter gram-negative quorum-sensing molecules in the airway surface liquid. P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cefae183d9381992c5608e8536559dda
https://doi.org/10.2500/ajra.2016.30.4331
https://doi.org/10.2500/ajra.2016.30.4331
Autor:
Carl M. Truesdale, James N. Palmer, Corrine Mansfield, Nithin D. Adappa, David W. Kennedy, Beverly J. Cowart, Noam A. Cohen, Laurel Doghramji, Alan D. Workman
Publikováno v:
International Forum of Allergy & Rhinology. 6:783-791
Background Sinonasal biofilms have been demonstrated in specimens collected from chronic rhinosinusitis (CRS) patients. Mounting evidence suggests that biofilms contribute to therapeutically recalcitrant CRS. Recently, the bitter taste receptor T2R38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbeae4295c17af5a238152357d20f282
https://doi.org/10.1002/alr.21803
https://doi.org/10.1002/alr.21803
Autor:
Michael A. Kohanski, Bei Chen, Neil N. Patel, Li-Yin Hung, James N. Palmer, Julie P. Shtraks, Nithin D. Adappa, De’Broski R. Herbert, Laurel Doghramji, Noam A. Cohen, David W. Kennedy, Mariel Blasetti, Alan D. Workman
Publikováno v:
J Allergy Clin Immunol
BACKGROUND: IL-25 can function as an early signal for the respiratory Type 2 response characteristic of allergic asthma and chronic rhinosinusitis with nasal polyps (CRSwNP). In the mouse gut, tuft cells are the epithelial source of IL-25. However, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb26aeb44b6e93e0427524cbee42bc2a
https://europepmc.org/articles/PMC9057652/
https://europepmc.org/articles/PMC9057652/
Autor:
Danielle R. Reed, Laurel Doghramji, Peihua Jiang, David W. Kennedy, Nithin D. Adappa, James N. Palmer, Corrine Mansfield, Robert J. Lee, Jenna R. Freund
Bitter taste receptors (taste family 2 bitter receptor proteins; T2Rs), discovered in many tissues outside the tongue, have recently become potential therapeutic targets. We have shown previously that airway epithelial cells express several T2Rs that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a66fc5d7848125c913d269943476822
https://europepmc.org/articles/PMC6016477/
https://europepmc.org/articles/PMC6016477/