Zobrazeno 1 - 10 of 61 pro vyhledávání: '"Laurel, Mendelsohn"'
1
Akademický článek
An Imaging Flow Cytometry Method to Measure Citrullination of H4 Histone as a Read-out for Neutrophil Extracellular Traps Formation
Autor: Emilia Barbu, Venina Dominical, Laurel Mendelsohn, Swee Lay Thein
Publikováno v: Bio-Protocol, Vol 11, Iss 4 (2021)
The formation of neutrophil extracellular traps (NETs) is thought to play a critical role in infections and propagating sterile inflammation. Histone citrullination is an essential and early step in NETs formation, detectable prior to the formation o
Externí odkaz: https://doaj.org/article/5a93abc71c584d4aa01fbb3da59c9abe
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2
Akademický článek
Detection and Quantification of Histone H4 Citrullination in Early NETosis With Image Flow Cytometry Version 4
Autor: Emilia A. Barbu, Venina M. Dominical, Laurel Mendelsohn, Swee Lay Thein
Publikováno v: Frontiers in Immunology, Vol 11 (2020)
Neutrophil extracellular traps (NETs) formation has been implicated in an increasing number of infectious and non-infectious pathologies. NETosis is a tightly regulated process; the end-stage and read-out is the formation of DNA strands extruded from
Externí odkaz: https://doaj.org/article/cacd4d3a7bf44e308b14678300b47f7d
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3
Akademický článek
Neutrophils remain detrimentally active in hydroxyurea-treated patients with sickle cell disease.
Autor: Emilia Alina Barbu, Venina M Dominical, Laurel Mendelsohn, Swee Lay Thein
Publikováno v: PLoS ONE, Vol 14, Iss 12, p e0226583 (2019)
Neutrophilia is a feature of sickle cell disease (SCD) that has been consistently correlated with clinical severity and has been shown to remain highly activated even at steady state. In addition to induction of fetal hemoglobin (HbF), hydroxyurea (H
Externí odkaz: https://doaj.org/article/02c97e64d05b4045bc626fa25ebdd211
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6
An Imaging Flow Cytometry Method to Measure Citrullination of H4 Histone as a Read-out for Neutrophil Extracellular Traps Formation
Autor: Venina Marcela Dominical, Laurel Mendelsohn, Swee Lay Thein, Emilia Alina Barbu
Publikováno v: Bio Protoc
The formation of neutrophil extracellular traps (NETs) is thought to play a critical role in infections and propagating sterile inflammation. Histone citrullination is an essential and early step in NETs formation, detectable prior to the formation o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a5f244b575a4a778136bc0e4adbbdaa
https://doi.org/10.21769/bioprotoc.3927
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7
The platelet NLRP3 inflammasome is upregulated in sickle cell disease via HMGB1/TLR4 and Bruton tyrosine kinase
Autor: Sebastian Vogel, Swee Lay Thein, Zenaide M.N. Quezado, James S. Nichols, Taruna Arora, Laurel Mendelsohn, Xunde Wang, Arun S. Shet, Darlene Allen, Christian A. Combs
Publikováno v: Blood Advances. 2:2672-2680
A key inflammatory mechanism recently identified in platelets involves the Nod-like receptor nucleotide-binding domain leucine-rich repeat containing protein 3 (NLRP3) and Bruton tyrosine kinase (BTK), which control activation of caspase-1 within inf
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26406e723e23bfe96d742ca16d17b5e5
https://doi.org/10.1182/bloodadvances.2018021709
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8
GlycA is not a useful biomarker of inflammation in sickle cell disease
Autor: Darlene Allen, Arun S. Shet, Julie K. Weisman, Daveena Meeks, Swee Lay Thein, Alan T. Remaley, Maureen Sampson, Laurel Mendelsohn, Jim Nichols
Publikováno v: International journal of laboratory hematology
Introduction: Sickle cell disease (SCD) is a multisystemic disorder, the pathology being driven by recurrent inflammation particularly during a vaso-occlusive crisis. GlycA, a composite measure of protein glycation, is a sensitive biomarker for disor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::347f1ccde028becbee0b744efdb0b13a
https://doi.org/10.1111/ijlh.12907
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9
Akademický článek
Apolipoprotein A-I and serum amyloid A plasma levels are biomarkers of acute painful episodes in patients with sickle cell disease
Autor: Ashaunta Tumblin, Anitaben Tailor, Gerard T. Hoehn, A. Kyle Mack, Laurel Mendelsohn, Lita Freeman, Xiuli Xu, Alan T. Remaley, Peter J. Munson, Anthony F. Suffredini, Gregory J. Kato
Publikováno v: Haematologica, Vol 95, Iss 9 (2010)
Background Acute painful episodes are the clinical hallmark of sickle cell disease and have been linked to morbidity and mortality in the sickle cell population.Design and Methods We undertook exploratory proteomic studies on paired plasma samples co
Externí odkaz: https://doaj.org/article/be1fac7d2a314cf593187bb59bc8a1a6
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10
Akademický článek
Chronic hyper-hemolysis in sickle cell anemia: association of vascular complications and mortality with less frequent vasoocclusive pain.
Autor: James G Taylor, Vikki G Nolan, Laurel Mendelsohn, Gregory J Kato, Mark T Gladwin, Martin H Steinberg
Publikováno v: PLoS ONE, Vol 3, Iss 5, p e2095 (2008)
BACKGROUND:Intravascular hemolysis in sickle cell anemia could contribute to complications associated with nitric oxide deficiency, advancing age, and increased mortality. We have previously reported that intense hemolysis is associated with increase
Externí odkaz: https://doaj.org/article/0c370d60034048fa9133380125bbdc88
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