Dissection of the TssB-TssC interface during type VI secretion sheath complex formation.

Autor: Xiang Y Zhang, Yannick R Brunet, Laureen Logger, Badreddine Douzi, Christian Cambillau, Laure Journet, Eric Cascales

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e81074 (2013)

The Type VI secretion system (T6SS) is a versatile machine that delivers toxins into either eukaryotic or bacterial cells. At a molecular level, the T6SS is composed of a membrane complex that anchors a long cytoplasmic tubular structure to the cell

Externí odkaz: https://doaj.org/article/75250badd1cb4ba1833b2e4523564fc0

In situ and high-resolution Cryo-EM structure of the Type VI secretion membrane complex

Autor: Riccardo Pellarin, Victoria Schmidt, Yassine Cherrak, Laureen Logger, Rémi Fronzes, Romain Kooger, Chiara Rapisarda, Eric Durand, Eric Cascales, Martin Pilhofer

Publikováno v: EMBO Journal
EMBO Journal, EMBO Press, 2019, 38 (10), ⟨10.15252/embj.2018100886⟩
EMBO Journal, 2019, 38 (10), ⟨10.15252/embj.2018100886⟩

Bacteria have evolved macromolecular machineries that secrete effectors and toxins to survive and thrive in diverse environments. The type VI secretion system (T6SS) is a contractile machine that is related to Myoviridae phages. The T6SS is composed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54d031571feb22378b1e9adcfd7d8e36
https://doi.org/10.1101/441683

Fusion Reporter Approaches to Monitoring Transmembrane Helix Interactions in Bacterial Membranes

Autor: Laureen, Logger, Abdelrahim, Zoued, Eric, Cascales

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1615

In transenvelope multiprotein machines such as bacterial secretion systems, protein-protein interactions not only occur between soluble domains but might also be mediated by helix-helix contacts in the inner membrane. Here we describe genetic assays

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9863745f1d5e57db9c7f1d858bd37310
https://pubmed.ncbi.nlm.nih.gov/28667614

Molecular Dissection of the Interface between the Type VI Secretion TssM Cytoplasmic Domain and the TssG Baseplate Component

Autor: Marie Guérin, Eric Durand, Laureen Logger, Eric Cascales, Marie-Stéphanie Aschtgen

Publikováno v: Journal of Molecular Biology
Journal of Molecular Biology, 2016, 428 (22), pp.4424-4437. ⟨10.1016/j.jmb.2016.08.032⟩
Journal of Molecular Biology, Elsevier, 2016, 428 (22), pp.4424-4437. ⟨10.1016/j.jmb.2016.08.032⟩

The type VI secretion system (T6SS) is a multiprotein complex that catalyses toxin secretion through the bacterial cell envelope of various Gram-negative bacteria including important human pathogens. This machine uses a bacteriophage-like contractile

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::732a5912b26189f4a7101487f7bec477
https://hal-amu.archives-ouvertes.fr/hal-01780174/file/0-Logger-TssMc-Text-REVISED.pdf

H-NS Silencing of the Salmonella Pathogenicity Island 6-Encoded Type VI Secretion System Limits Salmonella enterica Serovar Typhimurium Interbacterial Killing

Autor: Laurent Aussel, Yannick R. Brunet, Eric Cascales, Tâm Mignot, Ahmad Khodr, Laureen Logger, Sylvie Rimsky

Publikováno v: Infection and Immunity
Infection and Immunity, 2015, 83 (7), pp.2738--2750. ⟨10.1128/IAI.00198-15⟩
Infection and Immunity, American Society for Microbiology, 2015, 83 (7), pp.2738-2750. ⟨10.1128/IAI.00198-15⟩
Infection and Immunity, American Society for Microbiology, 2015, 83 (7), pp.2738--2750. 〈10.1128/IAI.00198-15〉
Infection and Immunity, American Society for Microbiology, 2015, 83 (7), pp.2738--2750. ⟨10.1128/IAI.00198-15⟩
Infection and Immunity, 2015, 83 (7), pp.2738-2750. ⟨10.1128/IAI.00198-15⟩

The secretion of bacterial toxin proteins is achieved by dedicated machineries called secretion systems. The type VI secretion system (T6SS) is a widespread versatile machine used for the delivery of protein toxins to both prokaryotic and eukaryotic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb8516a0a649e790f4b582b1c4461710
https://hal.science/hal-01452067