Výsledky vyhledávání - "Laureano Leonel Sabatier"

Diseño, síntesis y evaluación biológica de nuevos derivados de α-hidroxiamidas como agentes anticonvulsivos

Autor: Laureano Leonel Sabatier

Publikováno v: SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP

De acuerdo con la Organización Mundial de la Salud, existen más de 50 millones de personas en el mundo con Epilepsia, concentrándose la mayor proporción en países en vías de desarrollo. En Argentina, particularmente, se estima que 1 de cada 100

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948a8c7cef077cc172f58b276b5e6ad9
http://sedici.unlp.edu.ar/handle/10915/93992

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Design, synthesis and biological evaluation of N-substituted α-hydroxyimides and 1,2,3-oxathiazolidine-4-one-2,2-dioxides with anticonvulsant activity

Autor: Pablo Hernán Palestro, Andrea Enrique, Pedro Martín, Valentina Pastore, Luciana Gavernet, María Laura Sbaraglini, Laureano Leonel Sabatier

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 34, Iss 1, Pp 1465-1473 (2019)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

In this investigation, we studied a family of compounds with an oxathiazolidine-4-one-2,2-dioxide skeleton and their amide synthetic precursors as new anticonvulsant drugs. The cyclic structures were synthesized using a three-step protocol that inclu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1841d138c113b041c0afb791f4d41fb
https://pubmed.ncbi.nlm.nih.gov/31411081

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2’-Hydroxy-4’,5’-dimethyl-4-dimethylaminochalcone, a novel fluorescent flavonoid with capacity to detect aluminium in cells and modulate Alzheimer’s disease targets

Autor: Natalia Claudia Colettis, Fabiola Kamecki, Damijan Knez, Marina Rademacher, Luciana Gavernet, Stanislav Gobec, Felicitas de Tezanos Pinto, Mariel Marder, Laureano Leonel Sabatier, José Luis Eugenio Monti, Carolina Marcucci, Alejandra Marcos, Mariela S. Ferreira-Gomes

Publikováno v: Journal of Photochemistry and Photobiology A: Chemistry. 409:113137

Alzheimer’s disease (AD) is a progressive multifactorial neurodegenerative disorder with several factors contributing to its aetiology such as abnormal protein aggregation (e.g., β-amyloid peptide), oxidative stress, alterations in neurotransmitte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f2166a49495b22961110ca286a376de
https://doi.org/10.1016/j.jphotochem.2021.113137

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Searching for New Leads to Treat Epilepsy: Target-Based Virtual Screening for the Discovery of Anticonvulsant Agents

Autor: Pedro Martín, Maria Villalba, Luciana Gavernet, Sofía Goicoechea, Nicolás Jorge Enrique, Luis Enrique Bruno Blanch, Pablo Hernán Palestro, Verónica Milesi, Laureano Leonel Sabatier

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP

The purpose of this investigation is to contribute to the development of new anticonvulsant drugs to treat patients with refractory epilepsy. We applied a virtual screening protocol that involved the search into molecular databases of new compounds a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed9e458886f9780fe8dccb7661ff689d
http://pubs.acs.org/doi/10.1021/acs.jcim.7b00721

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Synthesis and anticonvulsant activity of bioisosteres of trimethadione, N-derivative-1,2,3-oxathiazolidine-4-one-2,2-dioxides from α-hydroxyamides

Autor: Andrea Enrique, Mariel Marder, Luis E. Bruno-Blanch, Laureano Leonel Sabatier, Valentina Pastore

Publikováno v: Bioorganicmedicinal chemistry. 21(4)

The synthesis and anticonvulsant activity of novel heterocycles N-derivative-1,2,3-oxathiazolidine-4-one-2,2-dioxides, bioisosteres of trimethadione (TMD, oxazolidine-2,4-dione) and phenytoin (PHE), are described. TMD is an anticonvulsant drug widely

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d49d35e4ef8cf40de41739bac894d0e1
https://pubmed.ncbi.nlm.nih.gov/23321016

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