Synthesis of Cyclic N ‐Hydroxylated Ureas and Oxazolidinone Oximes Enabled by Chemoselective Iodine(III)‐Mediated Radical or Cationic Cyclizations of Unsaturated N ‐Alkoxyureas

Autor: Kevin Cariou, Laure Peilleron, Pascal Retailleau

Publikováno v: Advanced Synthesis and Catalysis
Advanced Synthesis and Catalysis, Wiley-VCH Verlag, 2019, 361 (22), pp.5160-5169. ⟨10.1002/adsc.201901135⟩

International audience; In this study we describe the reactivity of unsaturated N-alkoxyureas in the presence of different combinations of a hypervalent iodine(III) reagent and a bromide source or TEMPO. Three complementary cyclizations can be achiev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff7fd13ed176d8d58df1abd54b61030d
https://doi.org/10.1002/adsc.201901135

Synthetic approaches towards avibactam and other diazabicyclooctane β-lactamase inhibitors

Autor: Kevin Cariou, Laure Peilleron

Publikováno v: Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2020, ⟨10.1039/C9OB02605C⟩

International audience; Avibactam is a non β-lactam β-lactamase inhibitor that has recently been approved in association with a β-lactam antibiotic for the treatment of severe infections caused by otherwise resistant bacteria. Its therapeutic succ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::827bcf5f35cdea44cbf7cc2243523537
https://hal.archives-ouvertes.fr/hal-02466833/file/RevueAvibactam.pdf

Halonium-Induced Polyene Cyclizations

Autor: Kevin Cariou, Tatyana D. Grayfer, Agathe C.A. D'Hollander, Laure Peilleron

Publikováno v: SYNTHESIS
SYNTHESIS, Georg Thieme Verlag, 2019, 51 (08), pp.1753-1769. ⟨10.1055/s-0037-1612254⟩

This review covers the methods that chemists have developed to access halogenated polycyclic structures from polyenes, by emulating Nature’s enzymatic machineries. From pioneering studies to the most recent developments, the different strategies, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b22b9b2f27f2c8e51a8317ffe4e9e13
https://hal.archives-ouvertes.fr/hal-02307164

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis

Autor: Mark F, van Delft, Stephane, Chappaz, Yelena, Khakham, Chinh T, Bui, Marlyse A, Debrincat, Kym N, Lowes, Jason M, Brouwer, Christoph, Grohmann, Phillip P, Sharp, Laura F, Dagley, Lucy, Li, Kate, McArthur, Meng-Xiao, Luo, Hui San, Chin, W Douglas, Fairlie, Erinna F, Lee, David, Segal, Stephane, Duflocq, Romina, Lessene, Sabrina, Bernard, Laure, Peilleron, Thao, Nguyen, Caroline, Miles, Soo San, Wan, Rachael M, Lane, Ahmad, Wardak, Kurt, Lackovic, Peter M, Colman, Jarrod J, Sandow, Andrew I, Webb, Peter E, Czabotar, Grant, Dewson, Keith G, Watson, David C S, Huang, Guillaume, Lessene, Benjamin T, Kile

Publikováno v: Nature chemical biology. 15(11)

Activating the intrinsic apoptosis pathway with small molecules is now a clinically validated approach to cancer therapy. In contrast, blocking apoptosis to prevent the death of healthy cells in disease settings has not been achieved. Caspases have b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0477b40e4e5384654fad1f5b446d351b
https://pubmed.ncbi.nlm.nih.gov/31591564