Leucine improves the aerosol performance of dry powder inhaler formulations of siRNA-loaded nanoparticles

Autor: You Xu, Laure Harinck, Abhijeet G. Lokras, Per Gerde, Ewa Selg, Carl-Olof Sjöberg, Henrik Franzyk, Aneesh Thakur, Camilla Foged

Publikováno v: Xu, Y, Harinck, L, Lokras, A G, Gerde, P, Selg, E, Sjöberg, C-O, Franzyk, H, Thakur, A & Foged, C 2022, ' Leucine improves the aerosol performance of dry powder inhaler formulations of siRNA-loaded nanoparticles ', International Journal of Pharmaceutics, vol. 621, 121758 . https://doi.org/10.1016/j.ijpharm.2022.121758

Thermostable dry powder inhaler (DPI) formulations with high aerosol performance are attractive inhalable solid dosage forms for local treatment of inflammatory lung diseases. We recently demonstrated that lipidoid-polymer hybrid nanoparticles (LPNs)

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https://pubmed.ncbi.nlm.nih.gov/35483619