Homeostatic regulation of axonal Kv1.1 channels accounts for both synaptic and intrinsic modifications in CA3 circuit

Autor: Norah Boumedine-Guignon, Juan José Garrido, Zbili M, Laure Fronzaroli-Molinieres, Andrzej Bialowas, Sylvain Rama, Dominique Debanne, María J. Benítez

Homeostatic plasticity of intrinsic excitability goes hand-in-hand with homeostatic plasticity of synaptic transmission. However, the mechanisms linking the two forms of homeostatic regulation have not been identified so far. Using electrophysiologic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd90edcbcd82ff2724d6b5d94f0a7b84
https://doi.org/10.1101/2021.04.22.440937

LGI1 tunes intrinsic excitability by regulating the density of axonal Kv1 channels

Autor: Léa Rodriguez, Fabrice Usseglio, Michaël Russier, Morgane Boillot, Fahamoe Youssouf, Norah Boumedine-Guignon, Mickaël Zbili, Christine Formisano-Tréziny, Michael Seagar, María J. Benítez, Marion Sangiardi, Laure Fronzaroli-Molinieres, Stéphanie Baulac, Olivier Caillard, Juan José Garrido, Yves Maulet, Marina De San Feliciano, Dominique Debanne, Oussama El Far

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2017, 114 (29), pp.7719-7724. ⟨10.1073/pnas.1618656114⟩
Proceedings of the National Academy of Sciences of the United States of America, 2017, 114 (29), pp.7719-7724. ⟨10.1073/pnas.1618656114⟩
Digital.CSIC. Repositorio Institucional del CSIC
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© The Author(s).
Autosomal dominant epilepsy with auditory features results from mutations in leucine-rich glioma-inactivated 1 (LGI1), a soluble glycoprotein secreted by neurons. Animal models of LGI1 depletion display spontaneous seizures, ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f623ed8dbbc0511470554df8022dc0f5
https://www.hal.inserm.fr/inserm-01708767

Presynaptic action potential waveform determines cortical synaptic latency

Autor: Laure Fronzaroli-Molinieres, Sami Boudkkazi, Dominique Debanne

Publikováno v: The Journal of Physiology. 589:1117-1131

Synaptic latency at cortical synapses is determined by the presynaptic release probability (Pr). Short- and long-term presynaptic plasticity is associated with modulation of synaptic delay. We show here that the duration and amplitude of the presynap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c654f46eef79ef9b66bb2eedd7e1607c
https://doi.org/10.1113/jphysiol.2010.199653

Metabotropic glutamate receptor subtype 1 regulates sodium currents in rat neocortical pyramidal neurons

Autor: Edmond Carlier, Dominique Debanne, Laure Fronzaroli-Molinieres, Patrice Déglise, Sami Boudkkazi, Valérie Sourdet, Norbert Ankri

Publikováno v: The Journal of Physiology. 577:141-154

Brain sodium channels (NaChs) are regulated by various neurotransmitters such as acetylcholine, serotonin and dopamine. However, it is not known whether NaCh activity is regulated by glutamate, the principal brain neurotransmitter. We show here that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f18f0c79515376352b31a3359b80b36
https://doi.org/10.1113/jphysiol.2006.118026

Analog modulation of spike-evoked transmission in CA3 circuits is determined by axonal Kv1.1 channels in a time-dependent manner

Autor: Sylvain Rama, Vincenzo Marra, Andrzej Bialowas, Dominique Debanne, Norbert Ankri, Mickaël Zbili, Laure Fronzaroli-Molinieres, Edmond Carlier

Publikováno v: European Journal of Neuroscience
European Journal of Neuroscience, Wiley, 2015, 41 (3), pp.293-304. ⟨10.1111/ejn.12787⟩
European Journal of Neuroscience, 2015, 41 (3), pp.293-304. ⟨10.1111/ejn.12787⟩

International audience; Synaptic transmission usually depends on action potentials (APs) in an all-or-none (digital) fashion. Recent studies indicate, however , that subthreshold presynaptic depolarization may facilitate spike-evoked transmission, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0f53a88e5ee72f425d79ed5c08fe33
https://pubmed.ncbi.nlm.nih.gov/25394682