OCT4 activates a Suv39h1-repressive antisense lncRNA to couple histone H3 Lysine 9 methylation to pluripotency

Autor: Laure D Bernard, Agnès Dubois, Victor Heurtier, Véronique Fischer, Inma Gonzalez, Almira Chervova, Alexandra Tachtsidi, Noa Gil, Nick Owens, Lawrence E Bates, Sandrine Vandormael-Pournin, José C R Silva, Igor Ulitsky, Michel Cohen-Tannoudji, Pablo Navarro

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, 2022, ⟨10.1093/nar/gkac550⟩
Bernard, L D, Dubois, A, Heurtier, V, Fischer, V, Gonzalez, I, Chervova, A, Tachtsidi, A, Gil, N, Owens, N, Bates, L E, Vandormael-Pournin, S, Silva, J C R, Ulitsky, I, Cohen-Tannoudji, M & Navarro, P 2022, ' OCT4 activates a Suv39h1-repressive antisense lncRNA to couple histone H3 Lysine 9 methylation to pluripotency ', Nucleic Acids Research, vol. 50, no. 13, pp. 7367-7379 . https://doi.org/10.1093/nar/gkac550

Histone H3 Lysine 9 (H3K9) methylation, a characteristic mark of heterochromatin, is progressively implemented during development to contribute to cell fate restriction as differentiation proceeds. Accordingly, in undifferentiated and pluripotent mou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb549b92a0f4c49361d981c802c8fbdd
https://hal-pasteur.archives-ouvertes.fr/pasteur-03719071/file/Bernard_etal_nar_revised_final.pdf

Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease

Autor: Tatyana Sukonnik, Fei Gu, Maximilian Haeussler, W. Patrick Devine, Reuben Thomas, Kavitha S. Rao, Michael H. Lai, Matthew L. Speir, William T. Pu, Irfan S. Kathiriya, Piyush Goyal, Bayardo I. Garay, Jonathan G. Seidman, Kai Li, Swetansu K. Hota, Andrew Blair, Benoit G. Bruneau, Henry Gong, Laure D. Bernard, Gunes A. Akgun, Holger Heyn, Lauren K. Wasson, Joshua M. Stuart, Giovanni Iacono, Kevin M. Hu, Brynn N. Akerberg, Christine E. Seidman

Publikováno v: Dev Cell
Developmental cell, vol 56, iss 3

Haploinsufficiency of transcriptional regulators causes human congenital heart disease (CHD); however, the underlying CHD gene regulatory network (GRN) imbalances are unknown. Here, we define transcriptional consequences of reduced dosage of the CHD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1355dc6ae49133bf02d2f38d8f2d4b43
https://doi.org/10.1016/j.devcel.2020.11.020