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ALS/FTD mutant CHCHD10 mice reveal a tissue-specific toxic gain-of-function and mitochondrial stress response

Autor: Samantha Meadows, Crystal Davis, Suzanne R. Burstein, Corey Anderson, Aamir Zuberi, Kirsten Bredvik, Teresa A. Milner, Jalia Dash, Alessandra Piersigilli, Giovanni Manfredi, Cathleen M. Lutz, Hibiki Kawamata, Laure Case

Publikováno v: Acta Neuropathol

Mutations in coiled-coil-helix-coiled-coil-helix domain containing 10 (CHCHD10), a mitochondrial protein of unknown function, cause a disease spectrum with clinical features of motor neuron disease, dementia, myopathy and cardiomyopathy. To investiga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d99e5af000f4c279f688e57bb9336a44
https://europepmc.org/articles/PMC6571048/

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Characterization and Optimization of SLE Mouse Models for the Evaluation of Immunomodulation Therapeutics

Autor: Laure Case, Hannah Knowlton, Greg Christianson, Lewis Vann, Cathleen Lutz

Publikováno v: The Journal of Immunology. 202:132.14-132.14

Systemic Lupus Erythematosus is a chronic autoimmune disease that causes systemic damage throughout the body and is characterized by a broad spectrum of clinical manifestations. The pathogenic mechanisms underlying the disease remain unclear, but are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::69cd04f26a455e1e0d96cb696ddcc97f
https://doi.org/10.4049/jimmunol.202.supp.132.14

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H1R signaling in antigen presenting cells is dispensable for eliciting pathogenic T cells in experimental allergic encephalomyelitis (123.14)

Autor: Naresha Saligrama, Rajkumar Noubade, Laure Case, Matthew Poynter, Cory Teuscher

Publikováno v: The Journal of Immunology. 188:123.14-123.14

The histamine H1 receptor (Hrh1/H1R) was identified as a shared autoimmune disease (SAID) gene in experimental allergic encephalomyelitis (EAE) and autoimmune orchitis, the principal AI models of multiple sclerosis (MS) and idiopathic male infertilit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc952e6eded598cdd06d3e3b3b7d1bca
https://doi.org/10.4049/jimmunol.188.supp.123.14

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Development of iNKT cells: influence of Y-chromosome genes (153.44)

Autor: Leon Toussaint, Laure Case, Stephanie Terrizzi, Jeffrey Ericson, Christophe Benoist, Cory Teuscher, Laurent Brossay

Publikováno v: The Journal of Immunology. 186:153.44-153.44

In previous studies, we identified a mouse strain, B6.Ynkt, in which only males were deficient in iNKT cells and demonstrated that the deficiency was linked to Y-chromosome factors. We reasoned that the deficiency could be due to either a consomic ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e080301a1d1e6790be902da34aa44d37
https://doi.org/10.4049/jimmunol.186.supp.153.44

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Evidence supporting the existence of a novel histaminergic pathway in the regulation of EAE susceptibility (143.51)

Autor: Naresha Saligrama, Roxana Del Rio, Laure Case, Rajkumar Noubade, Cory Teuscher

Publikováno v: The Journal of Immunology. 184:143.51-143.51

Histamine (HA) is a key regulator of experimental allergic encephalomyelitis (EAE), the autoimmune disease model of multiple sclerosis (MS). Histidine decarboxylase deficient mice (HDCKO), which are unable to synthesize HA, exhibit more severe EAE an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c619bd4ca78b96f136c6bf23c9874f2
https://doi.org/10.4049/jimmunol.184.supp.143.51

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