Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Laure C. Bouchez"'
Autor:
Heinz Ruffner, Joëlle Sprunger, Olga Charlat, Juliet Leighton-Davies, Bianka Grosshans, Adrian Salathe, Svenja Zietzling, Valérie Beck, Maxime Therier, Andrea Isken, Yang Xie, Yue Zhang, Huaixiang Hao, Xiaoying Shi, Dong Liu, Qinhui Song, Ieuan Clay, Gabriele Hintzen, Jan Tchorz, Laure C Bouchez, Gregory Michaud, Peter Finan, Vic E Myer, Tewis Bouwmeester, Jeff Porter, Marc Hild, Fred Bassilana, Christian N Parker, Feng Cong
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40976 (2012)
The Wnt/β-catenin signaling pathbway controls many important biological processes. R-Spondin (RSPO) proteins are a family of secreted molecules that strongly potentiate Wnt/β-catenin signaling, however, the molecular mechanism of RSPO action is not
Externí odkaz:
https://doaj.org/article/bd2794bcdd5c40a0903a9b2a0d7c9a22
Autor:
Anna Dubrovska, Jimmy Elliott, Richard J Salamone, Gennady D Telegeev, Alexander E Stakhovsky, Ihor B Schepotin, Feng Yan, Yan Wang, Laure C Bouchez, Sumith A Kularatne, James Watson, Christopher Trussell, Venkateshwar A Reddy, Charles Y Cho, Peter G Schultz
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31226 (2012)
Tumor progenitor cells represent a population of drug-resistant cells that can survive conventional chemotherapy and lead to tumor relapse. However, little is known of the role of tumor progenitors in prostate cancer metastasis. The studies reported
Externí odkaz:
https://doaj.org/article/41a17563a9034f63b5f9da5962d3b158
Publikováno v:
ACS Chemical Biology. 13:3354-3360
Hypoxia, conditions of reduced oxygen, occur in a wide variety of biological contexts, including solid tumours and bacterial biofilms, which are relevant to human health. Consequently, the development of chemical tools to study hypoxia is vital. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa3db7a678dac44bd4b5a169dbac8513
https://doi.org/10.1021/acschembio.8b00858
https://doi.org/10.1021/acschembio.8b00858
Autor:
Madeleine Livendahl, Cyril Gerbeaux, Marion Rusch, Maude Patoor, Laure C. Bouchez, Neil John Press
Publikováno v:
Synlett. 28:1219-1223
β-(2-Pyridyl) ketones are a unique class of heterocycles with valuable physicochemical properties and emerging relevance as pharmacophores. Herein we report a one-step process for the preparation of various substituted β-(2-pyridyl) ketones from th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9aefba8516d3c3a6a0bd7e3bc5da57fe
https://doi.org/10.1055/s-0036-1588154
https://doi.org/10.1055/s-0036-1588154
Autor:
Yitzhak Zimmer, Anna M. Schläfli, Daniel Candinas, Noelle Dommann, Adrian Keogh, Manuel O. Jakob, Mario P. Tschan, Michaela Medová, Sofia Karkampouna, Marianna Kruithof-de Julio, Vanessa Banz, Deborah Stroka, Jacopo Gavini, Laure C. Bouchez
Publikováno v:
Gavini, Jacopo; Dommann, Noëlle; Jakob, Manuel O.; Keogh, Adrian; Bouchez, Laure C; Karkampouna, Sofia; Kruithof-de Julio, Marianna; Medova, Michaela; Zimmer, Yitzhak; Schläfli, Anna M; Tschan, Mario P.; Candinas, Daniel; Stroka, Deborah; Banz, Vanessa (2019). Verteporfin-induced lysosomal compartment dysregulation potentiates the effect of sorafenib in hepatocellular carcinoma. Cell death & disease, 10(10), p. 749. Springer Nature 10.1038/s41419-019-1989-z
Cell Death and Disease, Vol 10, Iss 10, Pp 1-17 (2019)
Cell Death & Disease
Cell Death and Disease, Vol 10, Iss 10, Pp 1-17 (2019)
Cell Death & Disease
Lysosomal sequestration of anti-cancer compounds reduces drug availability at intracellular target sites, thereby limiting drug-sensitivity and inducing chemoresistance. For hepatocellular carcinoma (HCC), sorafenib (SF) is the first line systemic tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ce5c6df763b7e86cdfd85194d49f376
https://doi.org/10.1038/s41419-019-1989-z
https://doi.org/10.1038/s41419-019-1989-z
Autor:
Gabi Schutzius, Michael Faller, Aimee Reynolds, Ralph Tiedt, Julia Klopp, Florian Fuchs, Laure C. Bouchez, Federico Tortelli, Nelly Leroy, Jonathan J. Turner, Guglielmo Roma, Simona Cotesta, Armin Beyerbach, Peter Drueckes, Shola M Richards, Debora Bonenfant, Heinrich Rueeger, Heinz Ruffner, Jutta Blank, Rémi Terranova, Peter Tarsa, Frederic Grandjean, Florian Nigsch, Sebastian Bergling, Natalie Dales, Alexandra Aebi, Paul W. Manley, Markus Schirle, Christian Kolter, Tewis Bouwmeester, Rene Hemmig, Sukhdeep Sahambi, Lori L. Jennings, Walter Carbone, Felix Lohmann, Alfred Zimmerlin, Jun Li, Susan Kirkland, Steffen Renner, Mathias Frederiksen, Vickie Driver, Amy Berwick, Florence Zink, Jason R. Thomas, Andrea Vaupel, Chris Dimitri, Vito Guagnano, Viktoria Gruber, Malvina Louis, Caroline Gubser Keller, Adrian Salathe
Publikováno v:
Nature chemical biology. 17(3)
Although most acute skin wounds heal rapidly, non-healing skin ulcers represent an increasing and substantial unmet medical need that urgently requires effective therapeutics. Keratinocytes resurface wounds to re-establish the epidermal barrier by tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a8580afdc9f2d099758e215f9da05e
https://pubmed.ncbi.nlm.nih.gov/33462495
https://pubmed.ncbi.nlm.nih.gov/33462495
Autor:
Esther K. Schmitt, Christian Studer, Patrick Rollin, Madeleine Livendahl, Beatrice Ranieri, Marion Rusch, Carsten Spanka, Arnaud Thevenon, Thomas Aust, Maude Patoor, Laure C. Bouchez, Karl Gademann, Dominic Hoepfner
Publikováno v:
ChemBioChem.
Selective and specific inhibitors of Plasmodium falciparum lysyl-tRNA synthetase represent promising therapeutic antimalarial avenues. Cladosporin was identified as a potent P. falciparum lysyl-tRNA synthetase inhibitor, with an activity against para
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e4547cbd01479200bcf0ebb88267c47
https://doi.org/10.1002/cbic.201800587
https://doi.org/10.1002/cbic.201800587
Publikováno v:
Current Organic Chemistry. 20:2358-2378
Diels-Alder reactions have emerged as highly powerful transformations for the generation of structurally complex polycyclic scaffolds essentially due to their associated rapidity and atom-economy. Since its discovery in 1928, a better understanding o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9688e6f44abf6f1551e43ba620d280f
https://doi.org/10.2174/1385272820666160216000558
https://doi.org/10.2174/1385272820666160216000558
Autor:
Maude Patoor, Corinne Haller, Yvonne Ibig‐Rehm, Shola M. Richards, Carole Manneville, Matthias Mueller, Caroline Gubser Keller, Thierry Doll, Marjo Goette, Isabelle Fruh, Hyun-Woo Lee, Laure C. Bouchez
Publikováno v:
Stem Cells. 34:299-310
The multilineage differentiation capacity of mouse and human embryonic stem (ES) cells offers a testing platform for small molecules that mediate mammalian lineage determination and cellular specialization. Here we report the identification of two sm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c4e20d7dbd06b1f5eea261821397966
https://doi.org/10.1002/stem.2228
https://doi.org/10.1002/stem.2228
Autor:
Christian N. Parker, Guglielmo Roma, Laure C. Bouchez, Caroline Gubser Keller, Walter Carbone, Heinz Ruffner, Nicolas Melin, Svenja Ley, Alexandra Aebi, Judith Knehr, Susan Kirkland, Olaf Galuba, Martin Beibel, Adrian Salathe, Tewis Bouwmeester, Giovanni d'Ario, Florian Nigsch, Monika Pikiolek
Publikováno v:
SLAS discovery : advancing life sciences RD. 22(5)
Oral and intestinal mucositis is a debilitating side effect of radiation treatment. A mouse model of radiation-induced mucositis leads to weight loss and tissue damage, reflecting the human ailment as it responds to keratinocyte growth factor (KGF),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f4b2ec499e9dadab4f2bb111a6d12f0
https://pubmed.ncbi.nlm.nih.gov/28345372
https://pubmed.ncbi.nlm.nih.gov/28345372