Výsledky vyhledávání

Syntheses and Biological Activities (Topoisomerase Inhibition and Antitumor and Antimicrobial Properties) of Rebeccamycin Analogues Bearing Modified Sugar Moieties and Substituted on the Imide Nitrogen with a Methyl Group

Autor: Thomas Meyer, Danièle Sevère, Jean-François Riou, Fabrice Anizon, Laure Belin, Christian Bailly, Michelle Prudhomme, Doriano Fabbro, Monique Ollier, Martine Sancelme, Aline Voldoire, Pascale Moreau

Publikováno v: Journal of Medicinal Chemistry. 40:3456-3465

As a part of studies on structure-activity relationships, several potential topoisomerase I inhibitors were prepared. Different analogues of the antitumor antibiotic rebeccamycin substituted on the imide nitrogen with a methyl group were synthesized.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca0ab24858308c9484d7225e793ed483
https://doi.org/10.1021/jm9702084

Zobrazit plný text záznamu

Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties

Autor: Thomas Meyer, Doriano Fabbro, Jean-François Riou, Michelle Prudhomme, Martine Sancelme, Elisabète Rodrigues Pereira, Laure Belin, Monique Ollier, Danièle Sevère, Rapp Maryse

Publikováno v: Journal of medicinal chemistry. 39(22)

A series of compounds structurally related to staurosporine, rebeccamycin, and corresponding aglycones was synthesized, and their activities toward protein kinase C and topoisomerases I and II were tested together with their in vitro antitumor effici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7866d1e84610cd790ebce84a4c258af5
https://pubmed.ncbi.nlm.nih.gov/8893841

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání