Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Laura-An Guns"'
Autor:
Silvia Monteagudo, Frederique M. F. Cornelis, Carolina Aznar-Lopez, Ploi Yibmantasiri, Laura-An Guns, Peter Carmeliet, Frédéric Cailotto, Rik J. Lories
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
DOT1L is one of the few genes linked to osteoarthritis by human GWAS. Here the authors show that DOT1L-dependent histone methylation protects homeostasis of articular chondrocytes by SIRT1-dependent inhibition of canonical WNT signalling, and that in
Externí odkaz:
https://doaj.org/article/04bc89636776490eb64098d886437b56
Autor:
Ingrid Meulenbelt, Laura-An Guns, Rob G H H Nelissen, T. Peeters, F.M. Cornelis, Wouter den Hollander, Ilse Jonkers, Rik Lories, L. Storms, Silvia Monteagudo
Publikováno v:
Science Translational Medicine. 10
Osteoarthritis is the most common joint disorder with increasing global prevalence due to aging of the population. Current therapy is limited to symptom relief, yet there is no cure. Its multifactorial etiology includes oxidative stress and overprodu
Autor:
Frédéric Cailotto, Silvia Monteagudo, Peter Carmeliet, Carolina Aznar-Lopez, Rik Lories, Laura-An Guns, F.M. Cornelis, Ploi Yibmantasiri
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2017, 8, pp.15889. ⟨10.1038/ncomms15889⟩
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Nature Communications, Nature Publishing Group, 2017, 8, pp.15889. ⟨10.1038/ncomms15889⟩
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Osteoarthritis is the most prevalent and crippling joint disease, and lacks curative treatment, as the underlying molecular basis is unclear. Here, we show that DOT1L, an enzyme involved in histone methylation, is a master protector of cartilage heal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f9ca598f0864a75baf158d66c0e007
https://lirias.kuleuven.be/handle/123456789/592476
https://lirias.kuleuven.be/handle/123456789/592476
Autor:
Greet Kerckhofs, Erik Martens, Jennifer Vandooren, Laura-An Guns, Frédéric Cailotto, Rik Lories, Maryna Kvasnytsia, Ghislain Opdenakker
Publikováno v:
Pathogenic stroma.
Purpose Drug repositioning is a recent pharmaceutical strategy to discover new uses for market-approved drugs, with known safety profiles that can provide quick transition from the laboratory bench to bedside. Here, we investigate the influence of su
Publikováno v:
Osteoarthritis and Cartilage. 26:S32-S33
Autor:
Laura-An Guns, Frédéric Cailotto, Greet Kerckhofs, Jennifer Vandooren, Maryna Kvasnytsia, Erik Martens, Ghislain Opdenakker, Rik Lories
Publikováno v:
Osteoarthritis and Cartilage. 25:S145-S146
Autor:
Laura-An Guns, Ingrid Meulenbelt, Silvia Monteagudo, W. den Hollander, L. Storms, F.M. Cornelis, Rik Lories, T. Peeters
Publikováno v:
Osteoarthritis and Cartilage. 26:S21
Autor:
Laura-An Guns, Jennifer Vandooren, Maryna Kvasnytsia, Greet Kerckhofs, Frédéric Cailotto, Silvia Monteagudo, Ghislain Opdenakker, Rik Lories
Publikováno v:
RMD Open : Rheumatic & Musculoskeletal Diseases
RMD Open : Rheumatic & Musculoskeletal Diseases, EULAR ; BMJ, 2017, 3 (2), ⟨10.1136/rmdopen-2017-000604⟩
RMD Open, Vol. 3, no.2, p. e000604 (2017)
RMD Open
RMD Open : Rheumatic & Musculoskeletal Diseases, EULAR ; BMJ, 2017, 3 (2), ⟨10.1136/rmdopen-2017-000604⟩
RMD Open, Vol. 3, no.2, p. e000604 (2017)
RMD Open
Objectives Suramin is an old drug used for the treatment of African sleeping sickness. We investigated therapeutic repositioning of suramin to protect against cartilage damage, as suramin may interact with tissue inhibitor of metalloproteinase-3 (TIM
Publikováno v:
Annals of the Rheumatic Diseases. 75:A38.1-A38
Purpose A genome-wide association study (GWAS) identified an association between osteoarthritis and a gene cluster on chromosome 7 in which we proposed a role for G protein coupled receptor (GPR)22. This orphan receptor was found in OA cartilage whil
Publikováno v:
Annals of the Rheumatic Diseases. 73:A65.2-A65
Background Osteoarthritis (OA) is the most common type of arthritis and its prevalence increases in the ageing population. A genome-wide association study (GWAS) identified an OA susceptibility locus of approximately 500 kb on chromosome 7q22. This l