Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Laura del Barrio"'
Autor:
Itziar de Rojas, Laura del Barrio, Isabel Hernández, Laura Montrreal, Pablo García-González, Marta Marquié, Sergi Valero, Amanda Cano, Adelina Orellana, Mercè Boada, Santos Mañes, Agustín Ruiz
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2186 (2023)
Cholesterol efflux capacity (CEC) is of interest given its potential relationship with several important clinical conditions including Alzheimer’s disease. The inactivation of the APOE locus in mouse models supports the idea that it is involved in
Externí odkaz:
https://doaj.org/article/895d5ebd14004532a9af7d2dfedea882
Publikováno v:
The Scientific World Journal, Vol 11, Pp 2037-2050 (2011)
The inflammasome is an important innate immune pathway that regulates at least two host responses protective against infections: (1) secretion of the proinflammatory cytokines IL-1β and IL-18 and (2) induction of pyroptosis, a form of cell death. In
Externí odkaz:
https://doaj.org/article/559dd3c533a1417889decc28b8e65534
Autor:
Laura del Barrio, Manoranjan Sahoo, Louis Lantier, Joseph M Reynolds, Ivonne Ceballos-Olvera, Fabio Re
Publikováno v:
PLoS Pathogens, Vol 11, Iss 3, p e1004706 (2015)
The role of IL-1β and IL-18 during lung infection with the gram-negative bacterium Francisella tularensis LVS has not been characterized in detail. Here, using a mouse model of pneumonic tularemia, we show that both cytokines are protective, but thr
Externí odkaz:
https://doaj.org/article/e8dbe1b3ba1c4ef5bf9283e81aadcb6c
Publikováno v:
PLoS Pathogens, Vol 10, Iss 8, p e1004327 (2014)
Two distinct defense strategies can protect the host from infection: resistance is the ability to destroy the infectious agent, and tolerance is the ability to withstand infection by minimizing the negative impact it has on the host's health without
Externí odkaz:
https://doaj.org/article/7a55b1b8363549238a8a9c18025599b4
Publikováno v:
PLoS Pathogens, Vol 7, Iss 12, p e1002452 (2011)
Burkholderia pseudomallei is a Gram-negative bacterium that infects macrophages and other cell types and causes melioidosis. The interaction of B. pseudomallei with the inflammasome and the role of pyroptosis, IL-1β, and IL-18 during melioidosis hav
Externí odkaz:
https://doaj.org/article/a8032ea119884c45b828b1d27f653e31
Publikováno v:
Estudios de Lingüística, Iss 13, p 9 (1999)
This paper presents the results of an experimental analysis of the duration of Spanish consonants. The influence of three different factors—stress, location on the syllable, and pause vicinity— on the duration of consonants in reading text has be
Externí odkaz:
https://doaj.org/article/0e8f95ddf4ef4f69961a0b51b3c4ec61
Autor:
Viktória Jeney, Miguel P. Soares, Susana Ramos, Claudia Bank, Ana Ribeiro, Birte Blankenhaus, Raffaella Gozzelino, Temitope W. Ademolue, Faouzi Braza, Subhashini Bolisetty, Zélia Gouveia, Anupam Agarwal, Laura del Barrio, Damian L. Trujillo, Erida Gjini, Pedro Faísca, Abolfazl Zarjou, Silvia Cardoso, Balamurugan Sundaram, Ana Rita Carlos, Sofia Rebelo, Rui Martins
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences
Significance Malaria, the disease caused by Plasmodium spp. infection, remains a major global cause of morbidity and mortality, claiming the lives of over ∼4.5 × 105 individuals per year. Paradoxically, however, up to 98% of infected individuals s
Autor:
Sofia Rebelo, Rasmus Larsen, Michael Bauer, Sascha Schäuble, Laura del Barrio, Sebastian Weis, Sumnima Singh, Miguel P. Soares, Sandro Lindig, Maria Raquel Moita, Silvia Cardoso, Gilles Mithieux, Ana Rita Carlos, Birte Blankenhaus, Fabienne Rajas
Publikováno v:
Cell
Cell, Elsevier, 2017, 169 (7), pp.1263-1275.e14. ⟨10.1016/j.cell.2017.05.031⟩
Cell, Elsevier, 2017, 169 (7), pp.1263-1275.e14. ⟨10.1016/j.cell.2017.05.031⟩
International audience; Sepsis is an often lethal syndrome resulting from maladaptive immune and metabolic responses to infection, compromising host homeostasis. Disease tolerance is a defense strategy against infection that preserves host homeostasi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6353de810bd31d2c865406a50349f6
https://www.hal.inserm.fr/inserm-02339589
https://www.hal.inserm.fr/inserm-02339589
Publikováno v:
Current topics in medicinal chemistry. 17(9)
Alzheimer's disease (AD) is the most prevalent among the aging diseases known as neurodegenerative disorders. Drug design programs over the last two decades were mainly based on the cholinergic, the amyloid or the tau hypothesis. However, none of the
Autor:
José Marco-Contelles, Laura González-Lafuente, Maria Dolores Martin-de-Saavedra, Abdelouahid Samadi, Mourad Chioua, Agatha Bastida, Mercedes Villarroya, Laura del Barrio, Cristóbal de los Ríos, Luis Gandía, Inés Colmena, Carolina Valderas, Manuela G. López, Alejandro Romero
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:122-133
The synthesis, biological assessment, and molecular modelling of new tacrine analogues 11–22 is described. Compounds 11–22 have been obtained by Friedlander-type reaction of 2-aminopyridine-3-carbonitriles 1–10 with cyclohexanone or 1-benzyl-4-