Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Laura de Diego-García"'
Autor:
Linda Francistiová, Carolina Bianchi, Caterina Di Lauro, Álvaro Sebastián-Serrano, Laura de Diego-García, Julianna Kobolák, András Dinnyés, Miguel Díaz-Hernández
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease characterized by a progressive cognitive decline associated with global brain damage. Initially, intracellular paired helical filaments composed by hyperphosphorylated tau and
Externí odkaz:
https://doaj.org/article/8ad1c946efc34c1e9ccc6656461de0b0
Autor:
Carlos Martínez-Frailes, Caterina Di Lauro, Carolina Bianchi, Laura de Diego-García, Álvaro Sebastián-Serrano, Lisardo Boscá, Miguel Díaz-Hernández
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Alzheimer disease is a neurodegenerative disease characterized by the presence of senile plaques composed of amyloid-β (Aβ) peptide, neurofibrillary tangles, neuronal loss and neuroinflammation. Previous works have revealed that extracellular ATP,
Externí odkaz:
https://doaj.org/article/6a1944aeb4f3413ba7213ec9804a2080
Autor:
Álvaro Sebastián-Serrano, Laura de Diego-García, David C. Henshall, Tobías Engel, Miguel Díaz-Hernández
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Hypophosphatasia (HPP) is a rare heritable metabolic bone disease caused by hypomorphic mutations in the ALPL (in human) or Akp2 (in mouse) gene, encoding the tissue-nonspecific alkaline phosphatase (TNAP) enzyme. In addition to skeletal and dental m
Externí odkaz:
https://doaj.org/article/a912931503f949ce9f9342273387f977
Autor:
Álvaro Sebastián-Serrano, Laura de Diego-García, Carlos Martínez-Frailes, Jesús Ávila, Herbert Zimmermann, José Luis Millán, María Teresa Miras-Portugal, Miguel Díaz-Hernández
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 13, Iss C, Pp 95-100 (2015)
Tissue-nonspecific alkaline phosphatase (TNAP) is one of the four isozymes in humans and mice that have the capacity to hydrolyze phosphate groups from a wide spectrum of physiological substrates. Among these, TNAP degrades substrates implicated in n
Externí odkaz:
https://doaj.org/article/86722c46bd7a427e88aed7eb196d3292
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 4, p 998 (2018)
Tauopathies are a class of neurodegenerative diseases associated with the microtubule-associated protein tau, with Alzheimer’s disease (AD) being the most prevalent related disorder. Neurofibrillary tangles (NFTs) are one of the neuropathological h
Externí odkaz:
https://doaj.org/article/fc997765bad644c989386248dfa43a39
Autor:
Álvaro Sebastián-Serrano, Miguel Díaz-Hernández, Laura de Diego-García, Carolina Bianchi, Caterina Di Lauro
Publikováno v:
Brain Research Bulletin. 151:84-91
Neurodegenerative diseases (ND) are a heterogeneous group of neurological disorders characterized by a progressive loss of neuronal function which results in neuronal death. Although a specific toxic factor has been identified for each ND, all of the
Autor:
Hany El-Naggar, David C. Henshall, Norman Delanty, Edward Beamer, Faming Tian, Nicholas Dale, Austin Lacey, Laura de Diego-García, Tobias Engel, Felix Rosenow, Mohamed Khalil, Mariana Alves, Giorgia Conte
Publikováno v:
Epilepsia
Objective:\ud There is a major unmet need for a molecular biomarker of seizures or epilepsy that lends itself to fast, affordable detection in an easy‐to‐use point‐of‐care device. Purines such as adenosine triphosphate and adenosine are poten
Autor:
Alberto Parras, Laura de Diego-García, Mariana Alves, Raúl Méndez, Ivanna Ollá, Alejandro Ocampo, Razi Alalqam, Giorgia Conte, David C. Henshall, Edward Beamer, Tobias Engel, José J. Lucas
Publikováno v:
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Objective: Pharmacoresistance and the lack of disease-modifying actions of current antiseizure drugs persist as major challenges in the treatment of epilepsy. Experimental models of chemoconvulsant-induced status epilepticus remain the models of choi
Autor:
Gioacchino de Leo, Edward Beamer, Tobias Engel, Giorgia Conte, Annette Nicke, Jonathon Smith, Mariana Alves, Aida Menéndez-Méndez, Laura de Diego-García, James Morgan
Publikováno v:
Neurosci Bull
Mounting evidence suggests that the ATP-gated P2X7 receptor contributes to increased hyperexcitability in the brain. While increased expression of P2X7 in the hippocampus and cortex following status epilepticus and during epilepsy has been repeatedly
Polyadenylation of mRNA as a novel regulatory mechanism of gene expression in temporal lobe epilepsy
Autor:
Raúl Méndez, Michael A. Farrell, Alejandro Ocampo, Laura de Diego-García, Norman Delanty, Eva M. Jimenez-Mateos, James Morgan, Donncha F. O’Brien, Giorgia Conte, ivana olla, Yasmina E. Hernandez-Santana, Tobias Engel, Alberto Parras, Edward Beamer, David C. Henshall, Mariana Alves, José J. Lucas
Publikováno v:
Brain
Temporal lobe epilepsy is the most common and refractory form of epilepsy in adults. Gene expression within affected structures such as the hippocampus displays extensive dysregulation and is implicated as a central pathomechanism. Post-transcription