Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Laura Z Vanags"'
Autor:
Laura Z. Vanags, PhD, Joanne T.M. Tan, PhD, Keyvan K. Galougahi, MD, PhD, Andreas Schaefer, MD, Steven G. Wise, PhD, Andrew Murphy, PhD, Ziad A. Ali, MD, PhD, Christina A. Bursill, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 3, Iss 2, Pp 200-209 (2018)
Summary: Even the most advanced drug-eluting stents evoke unresolved issues, including chronic inflammation, late thrombosis, and neoatherosclerosis. This highlights the need for novel strategies that improve stent biocompatibility. Our studies show
Externí odkaz:
https://doaj.org/article/d8d4a7812f1546ab8a5dc2f65548598b
Autor:
Jamie Morton, MBBS, PhD, Shisan Bao, MD, PhD, Laura Z. Vanags, BSc, PhD, Tania Tsatralis, BSc, Anisyah Ridiandries, BSc, PhD, Chung-Wah Siu, MBBS, MD, Kwong-Man Ng, BSc, PhD, Joanne T.M. Tan, BSc, PhD, David S. Celermajer, MBBS, PhD, Martin K.C. Ng, MBBS, PhD, Christina A. Bursill, BSc, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 3, Iss 2, Pp 187-199 (2018)
Summary: Preclinical studies have shown benefit of apolipoprotein A-I (apoA-I)/high-density lipoprotein (HDL) raising in atherosclerosis; however, this has not yet translated into a successful clinical therapy. Our studies demonstrate that apoA-I rai
Externí odkaz:
https://doaj.org/article/191bf6b8123e4c32927bf2bc5abbd323
Autor:
Alex H P Chan, Richard P Tan, Praveesuda L Michael, Bob S L Lee, Laura Z Vanags, Martin K C Ng, Christina A Bursill, Steven G Wise
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174773 (2017)
Current animal models for the evaluation of synthetic grafts are lacking many of the molecular tools and transgenic studies available to other branches of biology. A mouse model of vascular grafting would allow for the study of molecular mechanisms o
Externí odkaz:
https://doaj.org/article/1140067a143145319250df802d6e349c
Autor:
Dhanya Ravindran, Anisyah Ridiandries, Laura Z Vanags, Rodney Henriquez, Siân Cartland, Joanne T M Tan, Christina A Bursill
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173224 (2017)
Chemokines are important in macrophage recruitment and the progression of atherosclerosis. The 'M3' chemokine binding protein inactivates key chemokines involved in atherosclerosis (e.g. CCL2, CCL5 and CX3CL1). We aimed to determine the effect of M3
Externí odkaz:
https://doaj.org/article/af89377ab6d54a9d893736137e15f008
Autor:
Nathan K. P. Wong, Helena Cheung, Emma L. Solly, Laura Z. Vanags, William Ritchie, Stephen J. Nicholls, Martin K. C. Ng, Christina A. Bursill, Joanne T. M. Tan
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 7, p 1903 (2018)
Angiogenesis, the process of forming new blood vessels, is crucial in the physiological response to ischemia, though it can be detrimental as part of inflammation and tumorigenesis. We have previously shown that high-density lipoproteins (HDL) modula
Externí odkaz:
https://doaj.org/article/a51a36687992442dba358fe0bbbf6314
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 38:1691-1701
Revascularization because of coronary artery disease is commonly achieved by percutaneous coronary intervention with stent deployment. Refinement in interventional techniques, major improvements in stent design (particularly drug-eluting stents), and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9db98f5e6ee4dc0189f816f999b31d00
https://doi.org/10.1161/atvbaha.118.310788
https://doi.org/10.1161/atvbaha.118.310788
Autor:
Andrew J. Murphy, Andreas Schaefer, Ziad A. Ali, Keyvan Karimi Galougahi, Laura Z. Vanags, Christina A. Bursill, Steven G. Wise, Joanne T.M. Tan
Publikováno v:
JACC: Basic to Translational Science
JACC: Basic to Translational Science, Vol 3, Iss 2, Pp 200-209 (2018)
JACC: Basic to Translational Science, Vol 3, Iss 2, Pp 200-209 (2018)
Visual Abstract
Highlights • This study shows that apoA-I may be an alternative strategy to improve the biocompatibility of stents. • Systemic infusions of apoA-I reduce in-stent neointimal hyperplasia in a murine model of stenting. • The
Highlights • This study shows that apoA-I may be an alternative strategy to improve the biocompatibility of stents. • Systemic infusions of apoA-I reduce in-stent neointimal hyperplasia in a murine model of stenting. • The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf29613c08e782ef2af3a4cf6892f334
http://europepmc.org/articles/PMC6060078
http://europepmc.org/articles/PMC6060078
Autor:
Kwong Man Ng, Jamie Morton, Joanne T.M. Tan, Laura Z. Vanags, Anisyah Ridiandries, David S. Celermajer, Tania Tsatralis, Shisan Bao, Chung-Wah Siu, Martin K.C. Ng, Christina A. Bursill
Publikováno v:
JACC: Basic to Translational Science, Vol 3, Iss 2, Pp 187-199 (2018)
JACC: Basic to Translational Science
JACC: Basic to Translational Science
Visual Abstract
Highlights • The atheroprotective effects of apoA-I are dependent on the plaque stage from which apoA-I is infused. • The atheroprotective effects of apoA-I infusions are also impaired in older mice with a greater disease mil
Highlights • The atheroprotective effects of apoA-I are dependent on the plaque stage from which apoA-I is infused. • The atheroprotective effects of apoA-I infusions are also impaired in older mice with a greater disease mil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b7103e8a8d1799e1d83c266d15cf9d
http://www.sciencedirect.com/science/article/pii/S2452302X17302838
http://www.sciencedirect.com/science/article/pii/S2452302X17302838
Autor:
Ziad A. Ali, Marcela M.M. Bilek, Laura Z. Vanags, Joanne T.M. Tan, Praveesuda S. Michael, Steven G. Wise, Christina A. Bursill, Miguel Santos
Publikováno v:
Nanomedicine: Nanotechnology, Biology and Medicine. 13:2141-2150
We utilized a plasma activated coating (PAC) to covalently bind the active component of high density lipoproteins (HDL), apolipoprotein (apo) A-I, to stainless steel (SS) surfaces. ApoA-I suppresses restenosis and thrombosis and may therefore improve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::149453d4273fd1d0f70d89842fecb67d
https://doi.org/10.1016/j.nano.2017.06.012
https://doi.org/10.1016/j.nano.2017.06.012
Autor:
Laura Lecce, Yuen Ting Lam, Zoe E. Clayton, Stacy Robertson, Tania Tsatralis, David S. Celermajer, Sui Ching G. Yuen, Joanne T.M. Tan, Louise L. Dunn, Martin K.C. Ng, Hamish C. G. Prosser, Christina A. Bursill, Anisyah Ridiandries, Laura Z. Vanags
Publikováno v:
Diabetes. 65:3091-3103
Disordered neovascularization and impaired wound healing are important contributors to diabetic vascular complications. We recently showed that high-density lipoproteins (HDLs) enhance ischemia-mediated neovascularization, and mounting evidence sugge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14141cca6d4a6ae85aeaeca6669ca1cf
https://doi.org/10.2337/db15-1668
https://doi.org/10.2337/db15-1668