Zobrazeno 1 - 10 of 338 pro vyhledávání: '"Laura Z Rassenti"'
1
Akademický článek
Aberrant spliceosome activity via elevated intron retention and upregulation and phosphorylation of SF3B1 in chronic lymphocytic leukemia
Autor: Manoj Kumar Kashyap, Hiren Karathia, Deepak Kumar, Roberto Vera Alvarez, Jose Vicente Forero-Forero, Eider Moreno, Juliana Velez Lujan, Carlos Ivan Amaya-Chanaga, Newton Medeiros Vidal, Zhe Yu, Emanuela M. Ghia, Paula A. Lengerke-Diaz, Daniel Achinko, Michael Y. Choi, Laura Z. Rassenti, Leonardo Mariño-Ramírez, Stephen M. Mount, Sridhar Hannenhalli, Thomas J. Kipps, Januario E. Castro
Publikováno v: Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102202- (2024)
Splicing factor 3b subunit 1 (SF3B1) is the largest subunit and core component of the spliceosome. Inhibition of SF3B1 was associated with an increase in broad intron retention (IR) on most transcripts, suggesting that IR can be used as a marker of s
Externí odkaz: https://doaj.org/article/adf59c81f6f94126a63b606708311ab5
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2
Akademický článek
A phase 1b study of zilovertamab in combination with paclitaxel for locally advanced/unresectable or metastatic HER2-negative breast cancer
Autor: Rebecca A. Shatsky, Hemali Batra-Sharma, Teresa Helsten, Richard B. Schwab, Emily I. Pittman, Minya Pu, Elizabeth Weihe, Emanuela M. Ghia, Laura Z. Rassenti, Alfredo Molinolo, Betty Cabrera, James B. Breitmeyer, George F. Widhopf, Karen Messer, Catriona Jamieson, Thomas J. Kipps, Barbara A. Parker
Publikováno v: Breast Cancer Research, Vol 26, Iss 1, Pp 1-10 (2024)
Abstract Background Zilovertamab is a humanized monoclonal antibody targeting ROR1, an onco-embryonic antigen expressed by malignant cells of a variety of solid tumors, including breast cancer. A prior phase 1 study showed that zilovertamab was well
Externí odkaz: https://doaj.org/article/0486bdf60d074a82b6fba59959ed172b
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4
Akademický článek
cyCombine allows for robust integration of single-cell cytometry datasets within and across technologies
Autor: Christina Bligaard Pedersen, Søren Helweg Dam, Mike Bogetofte Barnkob, Michael D. Leipold, Noelia Purroy, Laura Z. Rassenti, Thomas J. Kipps, Jennifer Nguyen, James Arthur Lederer, Satyen Harish Gohil, Catherine J. Wu, Lars Rønn Olsen
Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Combining single-cell cytometry datasets increases the analytical flexibility and the statistical power of data analyses. Here, the authors present a method to robustly integrate cytometry data from different batches, experiments, or even different e
Externí odkaz: https://doaj.org/article/6478e4f03ab74e9dbd3495199b84ead9
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5
Akademický článek
Impact of the Types and Relative Quantities of IGHV Gene Mutations in Predicting Prognosis of Patients With Chronic Lymphocytic Leukemia
Autor: Matthew Kaufman, Xiao-Jie Yan, Wentian Li, Emanuela M. Ghia, Anton W. Langerak, Laura Z. Rassenti, Chrysoula Belessi, Neil E. Kay, Frederic Davi, John C. Byrd, Sarka Pospisilova, Jennifer R. Brown, Mark Catherwood, Zadie Davis, David Oscier, Marco Montillo, Livio Trentin, Richard Rosenquist, Paolo Ghia, Jacqueline C. Barrientos, Jonathan E. Kolitz, Steven L. Allen, Kanti R. Rai, Kostas Stamatopoulos, Thomas J. Kipps, Donna Neuberg, Nicholas Chiorazzi
Publikováno v: Frontiers in Oncology, Vol 12 (2022)
Patients with CLL with mutated IGHV genes (M-CLL) have better outcomes than patients with unmutated IGHVs (U-CLL). Since U-CLL usually express immunoglobulins (IGs) that are more autoreactive and more effectively transduce signals to leukemic B cells
Externí odkaz: https://doaj.org/article/c619ded3a3974ed5becc2e624f138274
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6
Akademický článek
B-cell Receptor Signaling Induced Metabolic Alterations in Chronic Lymphocytic Leukemia Can Be Partially Bypassed by TP53 Abnormalities
Autor: Katarina Kluckova, Andrew J. Clear, Annalisa D’Avola, Laura Z. Rassenti, Thomas J. Kipps, John G. Gribben, John C. Riches
Publikováno v: HemaSphere, Vol 6, Iss 6, p e722 (2022)
It has been unclear what role metabolism is playing in the pathophysiology of chronic lymphocytic leukemia (CLL). One reason is that the study of CLL metabolism is challenging due to the resting nature of circulating CLL cells. Also, it is not clear
Externí odkaz: https://doaj.org/article/f8ebec7a7ae54bc1a1256e29c145678a
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7
Akademický článek
Genetic dynamics in untreated CLL patients with either stable or progressive disease: a longitudinal study
Autor: Alice Ramassone, Andrea D’Argenio, Angelo Veronese, Alessio Basti, Shimaa Hassan AbdelAziz Soliman, Stefano Volinia, Cristian Bassi, Sara Pagotto, Manuela Ferracin, Laura Lupini, Elena Saccenti, Veronica Balatti, Felice Pepe, Laura Z. Rassenti, Idanna Innocenti, Francesco Autore, Laura Marzetti, Renato Mariani-Costantini, Thomas J. Kipps, Massimo Negrini, Luca Laurenti, Rosa Visone
Publikováno v: Journal of Hematology & Oncology, Vol 12, Iss 1, Pp 1-5 (2019)
Abstract Clonal evolution of chronic lymphocytic leukemia (CLL) often follows chemotherapy and is associated with adverse outcome, but also occurs in untreated patients, in which case its predictive role is debated. We investigated whether the select
Externí odkaz: https://doaj.org/article/c1332f4fd0124ad88fe36c7515842edf
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10
Akademický článek
Targeting the CXCR4 pathway using a novel anti-CXCR4 IgG1 antibody (PF-06747143) in chronic lymphocytic leukemia
Autor: Manoj K. Kashyap, Carlos I. Amaya-Chanaga, Deepak Kumar, Brett Simmons, Nanni Huser, Yin Gu, Max Hallin, Kevin Lindquist, Rolla Yafawi, Michael Y. Choi, Ale-Ali Amine, Laura Z. Rassenti, Cathy Zhang, Shu-Hui Liu, Tod Smeal, Valeria R. Fantin, Thomas J. Kipps, Flavia Pernasetti, Januario E. Castro
Publikováno v: Journal of Hematology & Oncology, Vol 10, Iss 1, Pp 1-16 (2017)
Abstract Background The CXCR4-CXCL12 axis plays an important role in the chronic lymphocytic leukemia (CLL)-microenvironment interaction. Overexpression of CXCR4 has been reported in different hematological malignancies including CLL. Binding of the
Externí odkaz: https://doaj.org/article/c1cbefb66ea643659235e75122642524
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