Mechanical cell competition kills cells via induction of lethal p53 levels

Autor: Laura Wagstaff, Maja Goschorska, Kasia Kozyrska, Guillaume Duclos, Iwo Kucinski, Anatole Chessel, Lea Hampton-O’Neil, Charles R. Bradshaw, George E. Allen, Emma L. Rawlins, Pascal Silberzan, Rafael E. Carazo Salas, Eugenia Piddini

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)

Cell competition is a quality control mechanism to eliminate unfit cells. Here the authors show that physical compaction of less fit cells surrounded by healthy neighbours leads to increased expression of tumour suppressor p53 in the compacted cells,

Externí odkaz: https://doaj.org/article/917bfec21e0c49399454b3445695a286

How Right Now? Supporting Mental Health and Resilience Amid COVID-19

Autor: Amelia Burke-Garcia, Ashani Johnson-Turbes, Elizabeth W. Mitchell, Jorge M. Vallery Verlenden, Richard Puddy, Melissa C. Mercado, Pierce Nelson, Lucy Rabinowitz, Kanru Xia, Laura Wagstaff, Miao Feng, Larisa Caicedo, Emily Tolbert

Publikováno v: Traumatology (Tallahass Fla)

The How Right Now communication initiative (HRN) was developed to facilitate resilience amid the COVID-19 pandemic in the United States. HRN was designed as a conduit for promoting mental health and addressing feelings of grief, worry, and stress exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::168436877afb49f4efa09e2f3d077332
https://pubmed.ncbi.nlm.nih.gov/35360002

Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun

Autor: Shaline V. Fazal, Georg W. Otto, Peter Arthur-Farraj, Sergio Velasco-Aviles, Jose A. Gomez-Sanchez, Cristina Benito, Mark Turmaine, Rhona Mirsky, Liam Yn Wong, Kirolos Michael, Hugo Cabedo, Alastair M. Kilpatrick, Tessa Gordon, Kristjan R. Jessen, Ki H. Ma, Laura Wagstaff, John Svaren

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
eLife
eLife, Vol 10 (2021)
Wagstaff, L J, Gomez-Sanchez, J A, Fazal, S V, Otto, G W, Kilpatrick, A M, Michael, K, Wong, L YN, Ma, K H, Turmaine, M, Svaren, J, Gordon, T, Arthur-Farraj, P, Velasco-Aviles, S, Cabedo, H, Benito, C, Mirsky, R & Jessen, K R 2021, ' Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun ', eLIFE, vol. 10 . https://doi.org/10.7554/eLife.62232

After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that results from slow axon g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f21724dc2acf9c6f275b3d775968dd8a
https://doi.org/10.7554/elife.62232

Cell wars: regulation of cell survival and proliferation by cell competition

Autor: Eugenia Piddini, Laura Wagstaff, Silvia Vivarelli

Publikováno v: Essays in Biochemistry

During cell competition fitter cells take over the tissue at the expense of viable, but less fit, cells, which are eliminated by induction of apoptosis or senescence. This probably acts as a quality-control mechanism to eliminate suboptimal cells and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::057330c6da0d891d4152272fe5a6a1a1
https://doi.org/10.1042/bse0530069

Binding of Extracellular Maspin to β1 Integrins Inhibits Vascular Smooth Muscle Cell Migration

Autor: Rosemary Bass, Vincent Ellis, Lorna Ravenhill, Laura Wagstaff

Publikováno v: Journal of Biological Chemistry. 284:27712-27720

Maspin is a serpin that has multiple effects on cell behavior, including inhibition of migration. How maspin mediates these diverse effects remains unclear, as it is devoid of protease inhibitory activity. We have previously shown that maspin rapidly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aa87da332416b0f40c965dd58bf5444
https://doi.org/10.1074/jbc.m109.038919