Activation of Invariant Natural Killer T Cells Redirects the Inflammatory Response in Neonatal Sepsis

Autor: Alexandra C. Bolognese, Weng-Lang Yang, Laura W. Hansen, Archna Sharma, Jeffrey M. Nicastro, Gene F. Coppa, Ping Wang

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Sepsis is the third leading cause of death in the neonatal population, due to susceptibility to infection conferred by immaturity of both the innate and adaptive components of the immune system. Invariant natural killer T (iNKT) cells are specialized

Externí odkaz: https://doaj.org/article/79f27d2f9d8f4b20836d683948f641a4

Deficiency of receptor-interacting protein kinase 3 (RIPK3) attenuates inflammation and organ injury in neonatal sepsis

Autor: Gene F. Coppa, Asha Jacob, Jeffrey Nicastro, Jose M. Prince, Weng Lang Yang, Laura W. Hansen, Ping Wang, Alexandra C. Bolognese

Publikováno v: Journal of Pediatric Surgery. 53:1699-1705

Introduction Sepsis is the third leading cause of morbidity and mortality in neonates. Sepsis in neonates is characterized as the systemic inflammation owing to infection within the first 28days after birth. The molecular mechanism causing the exagge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d52414906525625602ab8bc43f6e750
https://doi.org/10.1016/j.jpedsurg.2017.11.054

Treatment with milk fat globule epidermal growth factor-factor 8 (MFG-E8) reduces inflammation and lung injury in neonatal sepsis

Autor: Tracy Chen, Jose M. Prince, Asha Jacob, Weng Lang Yang, Alexandra C. Bolognese, Jeffrey Nicastro, Gene F. Coppa, Ping Wang, Laura W. Hansen

Publikováno v: Surgery. 162:349-357

Background Sepsis remains one of the leading causes of infant death worldwide. It is characterized by uncontrolled inflammatory responses due to proven bacterial infection. Despite improvement in supportive care and the availability of effective anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed6cb79fd9f8fc3149439c2b86cbb3ec
https://doi.org/10.1016/j.surg.2017.02.006

Inhibition of necroptosis attenuates lung injury and improves survival in neonatal sepsis

Autor: Naomi-Liza Denning, Alexandra C. Bolognese, Gene F. Coppa, Ping Wang, Weng Lang Yang, Jeffrey Nicastro, Laura W. Hansen

Publikováno v: Surgery.

Background Neonatal sepsis represents a unique therapeutic challenge owing to an immature immune system. Necroptosis is a form of programmed cell death that has been identified as an important mechanism of inflammation-induced cell death. Receptor-in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e255f1a649cd1d6bf7a108d55d926581
https://pubmed.ncbi.nlm.nih.gov/29709367

List of Contributors

Autor: Sandra Abreu, Ceren Akal, Farhad Alavi, Wataru Aoi, Monowar Aziz, Siddhi M. Bagwe, Jocelyne R. Benatar, Helle Kirstine Mørup Bergholdt, Sukhwinder K. Bhullar, Claire Bourlieu, Wolfram M. Brück, Harpal S. Buttar, Peter Clifton, Lucia H. da Silva Miglioranza, Ilse De Bourdeaudhuij, Alejandra de Moreno de LeBlanc, Sara De Pelsmaeker, Hans De Steur, Ronald P. de Vries, Eda Deci, Isaias Dichi, Christina Ellervik, Zahra Emam-Djomeh, Javier Fontecha, Claudio Galli, Daniel Garrido, Xavier Gellynck, Christiane L. Girard, Benoît Graulet, Giuseppe Grosso, Laura W. Hansen, Alfheidur Haraldsdottir, Lars I. Hellgren, Michael Horowitz, Ying-Hsin Hsieh, Masayo Iwasa, Manuela Juárez, Ana Kapaj, Rajeev Kapila, Suman Kapila, Ginpreet Kaur, Naresh Kumar, Sofie Lagast, Manon Lecomte, Alina Li, Jie Li, Simin Liu, Marcell A.B. Lovozoy, Daniel R. Machin, Virginia E. Méndez Utz, Marie-Caroline Michalski, Mehdi Mohammadian, Luís A. Nero, Paul Nestel, Tirang R. Neyestani, Bahareh Nikooyeh, Pernille Nordby, Børge Grønne Nordestgaard, Sebnem Ozturkoglu-Budak, Gabriela Perdigón, Luana M. Perin, Jose M. Prince, Midathala Raghavendra, Christopher K. Rayner, Patrizia Risé, Maryam Salami, Bruna M. Scavuzzi, Joachim Jietse Schouteten, Valdemiro C. Sgarbieri, Rohit Sharma, Andréa N.C. Simão, Hari R. Singal, Yan Song, Irshad M. Sulaiman, Hirofumi Tanaka, Pamela Thomson, Jayanti Tokas, Johanna E. Torfadottir, Nazli Turkmen, Anette Varbo, Ping Wang, Linda E. Watson, Andrea S. Wiley, Tongzhi Wu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1b028073b087c08ec37124bb67273794
https://doi.org/10.1016/b978-0-12-809868-4.00044-3