Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Laura W Harris"'
Autor:
Ruidong Xiang, Martin Kelemen, Yu Xu, Laura W. Harris, Helen Parkinson, Michael Inouye, Samuel A. Lambert
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-14 (2024)
Abstract Polygenic scores (PGS) can be used for risk stratification by quantifying individuals’ genetic predisposition to disease, and many potentially clinically useful applications have been proposed. Here, we review the latest potential benefits
Externí odkaz:
https://doaj.org/article/afd2a65ad1024f02a94ecb4905c69f5e
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46368 (2012)
We have recently shown that a molecular biomarker signature comprised of inflammatory, hormonal and growth factors occurs in the blood serum from first onset schizophrenia patients. Here, we use the same platform to investigate post mortem brain tiss
Externí odkaz:
https://doaj.org/article/71868fd040e741eaa72d14fdcedca0ac
Autor:
Laura W Harris, Matthew Wayland, Martin Lan, Margaret Ryan, Thomas Giger, Helen Lockstone, Irene Wuethrich, Michael Mimmack, Lan Wang, Mark Kotter, Rachel Craddock, Sabine Bahn
Publikováno v:
PLoS ONE, Vol 3, Iss 12, p e3964 (2008)
BackgroundPrevious studies of brain and peripheral tissues in schizophrenia patients have indicated impaired energy supply to the brain. A number of studies have also demonstrated dysfunction of the microvasculature in schizophrenia patients. Togethe
Externí odkaz:
https://doaj.org/article/70b2569b333d4519a25dae37fa881661
Autor:
Ray Stefancsik, James P. Balhoff, Meghan A. Balk, Robyn Ball, Susan M. Bello, Anita R. Caron, Elissa Chessler, Vinicius de Souza, Sarah Gehrke, Melissa Haendel, Laura W. Harris, Nomi L. Harris, Arwa Ibrahim, Sebastian Koehler, Nicolas Matentzoglu, Julie A. McMurry, Christopher J. Mungall, Monica C. Munoz-Torres, Tim Putman, Peter Robinson, Damian Smedley, Elliot Sollis, Anne E Thessen, Nicole Vasilevsky, David O. Walton, David Osumi-Sutherland
Publikováno v:
bioRxiv
Existing phenotype ontologies were originally developed to represent phenotypes that manifest as a character state in relation to a wild-type or other reference. However, these do not include the phenotypic trait or attribute categories required for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3ba90afc362ce02ed181cd277391e8
https://doi.org/10.1101/2023.01.26.525742
https://doi.org/10.1101/2023.01.26.525742
Autor:
Elliot Sollis, Abayomi Mosaku, Ala Abid, Annalisa Buniello, Maria Cerezo, Laurent Gil, Tudor Groza, Osman Güneş, Peggy Hall, James Hayhurst, Arwa Ibrahim, Yue Ji, Sajo John, Elizabeth Lewis, Jacqueline A L MacArthur, Aoife McMahon, David Osumi-Sutherland, Kalliope Panoutsopoulou, Zoë Pendlington, Santhi Ramachandran, Ray Stefancsik, Jonathan Stewart, Patricia Whetzel, Robert Wilson, Lucia Hindorff, Fiona Cunningham, Samuel A Lambert, Michael Inouye, Helen Parkinson, Laura W Harris
Publikováno v:
Nucleic acids research.
The NHGRI-EBI GWAS Catalog (www.ebi.ac.uk/gwas) is a FAIR knowledgebase providing detailed, structured, standardised and interoperable genome-wide association study (GWAS) data to >200 000 users per year from academic research, healthcare and industr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab0d8788633b34367407df638d7a4bb4
https://pubmed.ncbi.nlm.nih.gov/36350656
https://pubmed.ncbi.nlm.nih.gov/36350656
Autor:
Aoife McMahon, Peggy Hall, Michael Inouye, Elliot Sollis, James D. Hayhurst, Stephen S. Rich, Maria Cerezo, Annalisa Buniello, Laura W. Harris, Inês Barroso, Helen Parkinson, Elizabeth Lewis, Ken Wiley, Teri A. Manolio, Lucia A. Hindorff, Robert J. Carroll, Patricia L. Whetzel, Jacqueline A. L. MacArthur, Orli G. Bahcall
Publikováno v:
Cell genomics. 1(1)
Summary Genome-wide association studies (GWASs) have enabled robust mapping of complex traits in humans. The open sharing of GWAS summary statistics (SumStats) is essential in facilitating the larger meta-analyses needed for increased power in resolv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f9488ce29170aab9153b5ff67f2b367
https://pubmed.ncbi.nlm.nih.gov/36082306
https://pubmed.ncbi.nlm.nih.gov/36082306
Autor:
Richard L.M. Faull, Jacqueline A. Sluijs, Lasse Brandt, Josef Priller, Francisco Fernández-Klett, Maurice A. Curtis, Jinte Middeldorp, Elly M. Hol, Laura W. Harris, Sabine Bahn, Basim Abuelnor, Camila Fernández-Zapata
Publikováno v:
Brain Pathology
Brain pathology 30(6), 1071-1086 (2020). doi:10.1111/bpa.12897
Brain pathology 30(6), 1071-1086 (2020). doi:10.1111/bpa.12897
Pericytes are vascular mural cells that surround capillaries of the central nervous system (CNS). They are crucial for brain development and contribute to CNS homeostasis by regulating blood–brain barrier function and cerebral blood flow. It has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c83072a81b007cc9892038c7fb723e51
https://doi.org/10.1111/bpa.12897
https://doi.org/10.1111/bpa.12897
Autor:
Heather Junkins, Paul Flicek, Joannella Morales, Peggy Hall, Harpreet Singh Riat, Elliot Sollis, Aoife McMahon, Stephen J. Trevanion, Laura W. Harris, Patricia L. Whetzel, James D. Hayhurst, Jacqueline A. L. MacArthur, M. Ridwan Amode, Fiona Cunningham, Annalisa Buniello, Daniel Suveges, Tony Burdett, Helen Parkinson, Olga Vrousgou, Jose A. Guillen, Cinzia Malangone, Lucia A. Hindorff, Edward Mountjoy, Maria Cerezo
Publikováno v:
Nucleic Acids Research
The GWAS Catalog delivers a high-quality curated collection of all published genome-wide association studies enabling investigations to identify causal variants, understand disease mechanisms, and establish targets for novel therapies. The scope of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b60d3105cc326f46e9be891e5eb48716
http://europepmc.org/articles/PMC6323933
http://europepmc.org/articles/PMC6323933
Autor:
Heather Junkins, Helen Parkinson, Annalisa Milano, Emma Hastings, Aoife McMahon, Tony Burdett, Joannella Morales, Emily H. Bowler, Danielle Welter, Fiona Cunningham, Laura W. Harris, Cinzia Malangone, Lucia A. Hindorff, Peggy Hall, Paul Flicek, Jacqueline A. L. MacArthur, Maria Cerezo, Annalisa Buniello
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-10 (2018)
Genome Biology
Genome Biology
BackgroundThe accurate description of ancestry is essential to interpret and integrate human genomics data, and to ensure that advances in the field of genomics benefit individuals from all ancestral backgrounds. However, there are no established gui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dd91a3ebb34320d4fba7d04116623f1
http://link.springer.com/article/10.1186/s13059-018-1396-2
http://link.springer.com/article/10.1186/s13059-018-1396-2
Autor:
Annalisa Buniello, Elliot Sollis, Laura W. Harris, Jacqueline A. L. MacArthur, Lucia A. Hindorff, Aoife McMahon, Helen Parkinson, Maria Cerezo, Elizabeth Lewis, Peggy Hall
Publikováno v:
Cell genomics
SUMMARY Genome sequencing has recently become a viable genotyping technology for use in genome-wide association studies (GWASs), offering the potential to analyze a broader range of genome-wide variation, including rare variants. To survey current st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d69fa090c2f40ca2dd9a776d4c7cae
https://doi.org/10.1016/j.xgen.2021.100005
https://doi.org/10.1016/j.xgen.2021.100005