Výsledky vyhledávání - "Laura W, Engstrom"

Akademický článek

A human tissue-based functional assay platform to evaluate the immune function impact of small molecule inhibitors that target the immune system.

Autor: Cristina St Pierre, Jane Guo, John D Shin, Laura W Engstrom, Hyun-Hee Lee, Alan Herbert, Laura Surdi, James Baker, Michael Salmon, Sanjiv Shah, J Michael Ellis, Hani Houshyar, Michael A Crackower, Melanie A Kleinschek, Dallas C Jones, Alexandra Hicks, Dennis M Zaller, Stephen E Alves, Ravisankar A Ramadas

Publikováno v: PLoS ONE, Vol 12, Iss 7, p e0180870 (2017)

While the immune system is essential for the maintenance of the homeostasis, health and survival of humans, aberrant immune responses can lead to chronic inflammatory and autoimmune disorders. Pharmacological modulation of drug targets in the immune

Externí odkaz: https://doaj.org/article/a511e5553a1e4c19982a055d21745012

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Akademický článek

Kinetic Assessment and Therapeutic Modulation of Metabolic and Inflammatory Profiles in Mice on a High-Fat and Cholesterol Diet

Autor: Laura W. Engstrom, Loretta Bober, Shu-Cheng Chen, Jay S. Fine, Ying Li, Michaela C. Stanton, David Kinsley, Long Cui, James V. Jackson, Alberto Rojas-Triana, Daniel Lundell, Maureen Laverty, Eric L. Gustafson, Chung-Her Jenh, Timothy J. Kowalski, Denise J. Manfra

Publikováno v: PPAR Research, Vol 2010 (2010)

The kinetics of metabolic and inflammatory parameters associated with obesity were evaluated in a murine diet-induced obesity (DIO) model using a diet high in fat and cholesterol. Cellular infiltration and mediator production were assessed and shown

Externí odkaz: https://doaj.org/article/cae9bc5d7d7f4e2ba1dbbdd988dcff99

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[Untitled]

Autor: Daniel Lundell, Laura W. Engstrom, Loretta A. Bober, James V. Jackson, Jay S. Fine, Alberto Rojas-Triana, Gregory Deno

Publikováno v: Inflammation. 27:161-174

We have characterized leukocyte migration to the pleural cavity in a methylated-BSA (mBSA)-induced model of murine delayed-type hypersensitivity and evaluated the ability of IL-4 and IL-10 to modulate this response. Neutrophils, macrophages, T cells,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aaa5be6adb4c1b0d91b83190e29fc436
https://doi.org/10.1023/a:1025076111950

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Durable engraftment of major histocompatibility complex–incompatible cells after nonmyeloablative conditioning with fludarabine, low-dose total body irradiation, and posttransplantation cyclophosphamide

Autor: Sanju Jalla, Leo Luznik, Laura W. Engstrom, Ephraim J. Fuchs, Robert Iannone

Publikováno v: Blood. 98:3456-3464

Treatment of leukemia by myeloablative conditioning and transplantation of major histocompatibility complex (MHC)–mismatched stem cells is generally avoided because of the high risk of graft rejection or lethal graft-versus-host disease (GVHD). Thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0035707592d14e97eda607e230fb08d5
https://doi.org/10.1182/blood.v98.12.3456

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Effects of mixed hematopoietic chimerism in a mouse model of bone marrow transplantation for sickle cell anemia

Autor: Leo Luznik, Ephraim J. Fuchs, Frederic B. Askin, Sherrie L. Tennessee, Lori Noffsinger, Laura W. Engstrom, James F. Casella, Thomas S. Kickler, Steven N. Goodman, Robert Iannone, Constance A. Griffin, Anita L. Hawkins

Publikováno v: Blood. 97:3960-3965

Sickle cell anemia (SCA) is an inherited disorder of beta-globin, resulting in red blood cell rigidity, anemia, painful crises, organ infarctions, and reduced life expectancy. Allogeneic blood or marrow transplantation (BMT) can cure SCA but is assoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aba1833a1ae55a88cd0929c683d3046
https://doi.org/10.1182/blood.v97.12.3960

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Kinetic Assessment and Therapeutic Modulation of Metabolic and Inflammatory Profiles in Mice on a High-Fat and Cholesterol Diet

Autor: Alberto Rojas-Triana, James V. Jackson, Denise Manfra, Jay S. Fine, Long Cui, Laura W. Engstrom, Daniel Lundell, David Kinsley, Timothy J. Kowalski, Ying Li, Maureen Laverty, Eric L. Gustafson, Michaela C. Stanton, Loretta A. Bober, Shu-Cheng Chen, Chung-Her Jenh

Publikováno v: PPAR Research, Vol 2010 (2010)
PPAR Research

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc2e2212981aad5357ad60de410c787b
https://doaj.org/article/cae9bc5d7d7f4e2ba1dbbdd988dcff99

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Characterization of a murine keyhole limpet hemocyanin (KLH)-delayed-type hypersensitivity (DTH) model: role for p38 kinase

Autor: Katsuhiro Mihara, Jay S. Fine, Ying Li, David Kinsley, Laura W. Engstrom, Rob Nelissen, M. Consuelo Pinzon-Ortiz, Shu-Cheng Chen, Denise Manfra

Publikováno v: International immunopharmacology. 9(10)

Molecular and cellular assessment of dermal delayed-type hypersensitivity (DTH) responses is a useful approach for evaluating the mechanism of action (MOA) of immunomodulatory agents. In the present report, we characterized the delayed-type hypersens

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3218ec1f5d77578bf585c4cead20d583
https://pubmed.ncbi.nlm.nih.gov/19616132

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Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation

Autor: Eric M. Parker, Maria Pinzon-Ortiz, Hubert B. Josien, Laura W. Engstrom, Gwendolyn T. Wong, Hu-Jung J. Lee, Lili Zhang, Jay S. Fine, Frederique M. Poulet, Qi Zhang, Thomas A. Bara, Guy A. Higgins, Denise Manfra

Publikováno v: The Journal of biological chemistry. 279(13)

Inhibition of gamma-secretase, one of the enzymes responsible for the cleavage of the amyloid precursor protein (APP) to produce the pathogenic beta-amyloid (Abeta) peptides, is an attractive approach to the treatment of Alzheimer disease. In additio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::805624b9692a5fcc38070efe53c1e9ab
https://pubmed.ncbi.nlm.nih.gov/14709552

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Impairment of leukocyte trafficking in a murine pleuritis model by IL-4 and IL-10

Autor: Jay S, Fine, Alberto, Rojas-Triana, James V, Jackson, Laura W, Engstrom, Gregory S, Deno, Daniel J, Lundell, Loretta A, Bober

Publikováno v: Inflammation. 27(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fc28e3de84d928b6e73d0c78a7a9eee9
https://pubmed.ncbi.nlm.nih.gov/14527170

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Posttransplantation cyclophosphamide facilitates engraftment of major histocompatibility complex-identical allogeneic marrow in mice conditioned with low-dose total body irradiation

Autor: Laura W. Engstrom, Ephraim J. Fuchs, Leo Luznik, Robert Iannone

Publikováno v: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 8(3)

Cyclophosphamide (Cy) has been studied extensively for its immunosuppressive properties and is frequently combined with total body irradiation (TBI) as conditioning prior to HLA-identical allogeneic blood or marrow transplantation (alloBMT) in humans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdf61dd0b2787dbf8653715247762422
https://pubmed.ncbi.nlm.nih.gov/11939602

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