Zobrazeno 1 - 10 of 28 pro vyhledávání: '"Laura Von Schantz"'
1
Akademický článek
RUBY® – a tetravalent (2+2) bispecific antibody format with excellent functionality and IgG-like stability, pharmacology and developability properties
Autor: Barnabas Nyesiga, Mattias Levin, Anna Säll, Anna Rosén, Kim Jansson, Sara Fritzell, Karin Hägerbrand, Dietmar Weilguny, Laura von Schantz
Publikováno v: mAbs, Vol 16, Iss 1 (2024)
ABSTRACTDespite the large number of existing bispecific antibody (bsAb) formats, the generation of novel bsAbs is still associated with development and bioprocessing challenges. Here, we present RUBY, a novel bispecific antibody format that allows ra
Externí odkaz: https://doaj.org/article/3554ed116f6c45079b118217d1d8fd6f
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2
Akademický článek
Bispecific antibodies targeting CD40 and tumor-associated antigens promote cross-priming of T cells resulting in an antitumor response superior to monospecific antibodies
Autor: Malin Lindstedt, Peter Ellmark, Lennart Greiff, Karin Hägerbrand, Laura von Schantz, Mia Thagesson, Doreen Werchau, Kristine Smedenfors, Anna Rosén, Anette Sundstedt, Adnan Deronic, Lill Ljung, Mattias Levin, Laura Varas, Anna Säll, Christina Sakellariou, Barnabas Nyesiga, David Gomez Jimenez, Mona Celander, Deniz Bölükbas, Fredrika Carlsson
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 11 (2022)
Background Indications with poor T-cell infiltration or deficiencies in T-cell priming and associated unresponsiveness to established immunotherapies represent an unmet medical need in oncology. CD40-targeting therapies designed to enhance antigen pr
Externí odkaz: https://doaj.org/article/3ded16f9cf504c5983b33e362b58d5fd
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4
Akademický článek
The CTLA-4 x OX40 bispecific antibody ATOR-1015 induces anti-tumor effects through tumor-directed immune activation
Autor: Anne Månsson Kvarnhammar, Niina Veitonmäki, Karin Hägerbrand, Anna Dahlman, Karin Enell Smith, Sara Fritzell, Laura von Schantz, Mia Thagesson, Doreen Werchau, Kristine Smedenfors, Maria Johansson, Anna Rosén, Ida Åberg, Magnus Winnerstam, Eva Nyblom, Karin Barchan, Christina Furebring, Per Norlén, Peter Ellmark
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-14 (2019)
Abstract Background The CTLA-4 blocking antibody ipilimumab has demonstrated substantial and durable effects in patients with melanoma. While CTLA-4 therapy, both as monotherapy and in combination with PD-1 targeting therapies, has great potential in
Externí odkaz: https://doaj.org/article/ac146a36143540ed83d59ae4ac9773f4
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6
Akademický článek
MICRODISTRIBUTION OF XYLOGLUCAN IN DIFFERENTIATING POPLAR CELLS
Autor: David Sandquist, Lada Filonova, Laura von Schantz, Mats Ohlin, Geoffrey Daniel
Publikováno v: BioResources, Vol 5, Iss 2, Pp 796-807 (2010)
Recent studies on the ultrastructure and composition of the gelatinous layer (g-layer) in poplar have reported findings of xyloglucan. Using correlated fluorescence, scanning- and transmission electron micros-copy, we found evidence for xyloglucan pr
Externí odkaz: https://doaj.org/article/d5f36b387a234bd4b985a1022ec7802a
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10
751 Neo-X-Prime bispecific antibodies targeting CD40 and tumor antigens promote cross-presentation of tumor exosome-derived neoantigen and induce superior anti-tumor responses compared to CD40 mAb
Autor: Barnabas Nyesiga, Mia Thagesson, Anna Rosén, Karin Hägerbrand, Mattias Levin, Karin Barchan, Laura Varas, Anette Sundstedt, Anna Säll, Doreen Werchau, Peter Ellmark, Lill Ljung, Laura Von Schantz, Eva Lindqvist, Adnan Deronic
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundAlligator's Neo-X-Prime platform aims to enable antigen presenting cells to efficiently enhance priming of tumor neoantigen-specific T cells with the goal of overcoming PD-1 resistance in certain tumor types. We hypothesize that binding of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::254b3a98cca7dddc470b999478d652d6
https://doaj.org/article/9e6a3658910c424b887736939f0b115c
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