Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Laura Virtanen"'
Autor:
Caroline Le Dour, Maria Chatzifrangkeskou, Coline Macquart, Maria M. Magiera, Cécile Peccate, Charlène Jouve, Laura Virtanen, Tiina Heliö, Katriina Aalto-Setälä, Silvia Crasto, Bruno Cadot, Déborah Cardoso, Nathalie Mougenot, Daniel Adesse, Elisa Di Pasquale, Jean-Sébastien Hulot, Pekka Taimen, Carsten Janke, Antoine Muchir
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Lamin A/C gene mutations cause dilated cardiomyopathy associated with cofilin-1 phosphorylation and actin destabilization. Here, the authors show that phosphorylated cofilin-1 blunts the MRTF-A/SRF axis, leading to decreased tubulin acetylation and a
Externí odkaz:
https://doaj.org/article/ef932080f9164edd9c93891a4153a646
Autor:
Gun West, Minttu Turunen, Anna Aalto, Laura Virtanen, Song-Ping Li, Tiina Heliö, Annika Meinander, Pekka Taimen
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Lamins A and C are nuclear intermediate filament proteins that form a proteinaceous meshwork called lamina beneath the inner nuclear membrane. Mutations in the LMNA gene encoding lamins A and C cause a heterogenous group of inherited degenerative dis
Externí odkaz:
https://doaj.org/article/36547d1f42a541a680ba43e8f60e69a4
Autor:
Disheet Shah, Laura Virtanen, Chandra Prajapati, Mostafa Kiamehr, Josef Gullmets, Gun West, Joose Kreutzer, Mari Pekkanen-Mattila, Tiina Heliö, Pasi Kallio, Pekka Taimen, Katriina Aalto-Setälä
Publikováno v:
Cells, Vol 8, Iss 6, p 594 (2019)
Dilated cardiomyopathy (DCM) is one of the leading causes of heart failure and heart transplantation. A portion of familial DCM is due to mutations in the LMNA gene encoding the nuclear lamina proteins lamin A and C and without adequate treatment the
Externí odkaz:
https://doaj.org/article/c6fb85b811c545bca8652ab8309eb771
Publikováno v:
Cells, Vol 8, Iss 4, p 361 (2019)
The nuclear lamina consists of a dense fibrous meshwork of nuclear lamins, Type V intermediate filaments, and is ~14 nm thick according to recent cryo-electron tomography studies. Recent advances in light microscopy have extended the resolution to a
Externí odkaz:
https://doaj.org/article/c653fd0c32264b33aa06643e0647a78a
Autor:
Pekka Taimen, Timo Savunen, Laura Liikamaa, Laura Virtanen, Markus Malmberg, Emily Pan, Jarmo Gunn, Maija Hollmén, Sirpa Jalkanen, Emmi Saura, Vesa Anttila, Siiri Deomic Niittynen, Juho Jalkanen
Publikováno v:
The Heart Surgery Forum. 24:E409-E413
Background: To investigate the potential of intravenously administered porcine recombinant interferon-β1a (IFN-β1a) for myocardial protection during acute ischemia-reperfusion (IR) injury in an experimental animal model. Methods: Twenty-two piglets
Autor:
Laura Virtanen, Emilia Holm, Mona Halme, Gun West, Fanny Lindholm, Josef Gullmets, Juho Irjala, Tiina Heliö, Artur Padzik, Annika Meinander, John E. Eriksson, Pekka Taimen
The heat shock (HS) response is crucial for cell survival in harmful environments. Nuclear lamin A/C, encoded by LMNA gene, has been shown to contribute towards altered gene expression during heat shock, but the underlying mechanisms are poorly under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dd3342cfbe4117696f82d564ebe6c9f
https://doi.org/10.1101/2022.01.19.476880
https://doi.org/10.1101/2022.01.19.476880
Autor:
Chiara D’Ercole, Paolo D’Angelo, Veronica Ruggieri, Daisy Proietti, Laura Virtanen, Cristina Parisi, Carles Sanchez Riera, Alessandra Renzini, Alberto Macone, Marta Marzullo, Laura Ciapponi, Davide Bonvissuto, Claudio Sette, Lorenzo Giordani, Luca Madaro
Striated muscle is a highly organized structure composed of well-defined anatomical domains with integrated but distinct assignments. So far, the lack of a direct correlation between tissue architecture and gene expression has limited our understandi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01c899847cabbf32e88487fcc0ececa
https://hdl.handle.net/11573/1662908
https://hdl.handle.net/11573/1662908
Autor:
Caroline Le Dour, Maria Chatzifrangkeskou, Coline Macquart, Maria M. Magiera, Cécile Peccate, Charlène Jouve, Laura Virtanen, Tiina Heliö, Katriina Aalto-Setälä, Silvia Crasto, Bruno Cadot, Déborah Cardoso, Nathalie Mougenot, Daniel Adesse, Elisa Di Pasquale, Jean-Sébastien Hulot, Pekka Taimen, Carsten Janke, Antoine Muchir
Publikováno v:
Nature communications. 13(1)
Mutations in the lamin A/C gene (LMNA) cause dilated cardiomyopathy associated with increased activity of ERK1/2 in the heart. We recently showed that ERK1/2 phosphorylates cofilin-1 on threonine 25 (phospho(T25)-cofilin-1) that in turn disassembles
Autor:
Chandra Prajapati, Pekka Taimen, Mostafa Kiamehr, Gun West, Katriina Aalto-Setälä, Tiina Heliö, Mari Pekkanen-Mattila, Laura Virtanen, Pasi Kallio, Disheet Shah, Josef Gullmets, Joose Kreutzer
Publikováno v:
Cells
Volume 8
Issue 6
Cells, Vol 8, Iss 6, p 594 (2019)
Volume 8
Issue 6
Cells, Vol 8, Iss 6, p 594 (2019)
Dilated cardiomyopathy (DCM) is one of the leading causes of heart failure and heart transplantation. A portion of familial DCM is due to mutations in the LMNA gene encoding the nuclear lamina proteins lamin A and C and without adequate treatment the
Autor:
Joose Kreutzer, Pasi Kallio, Disheet Shah, Mostafa Kiamehr, Katriina Aalto-Setälä, Mari Pekkanen-Mattila, Pekka Taimen, Laura Virtanen
Publikováno v:
Cardiovascular Research. 114:S128-S129