Comparing the Efficacy of Two Generations of EGFR-TKIs: An Integrated Drug–Disease Mechanistic Model Approach in EGFR-Mutated Lung Adenocarcinoma

Autor: Hippolyte Darré, Perrine Masson, Arnaud Nativel, Laura Villain, Diane Lefaudeux, Claire Couty, Bastien Martin, Evgueni Jacob, Michaël Duruisseaux, Jean-Louis Palgen, Claudio Monteiro, Adèle L’Hostis

Publikováno v: Biomedicines, Vol 12, Iss 3, p 704 (2024)

Mutationsin epidermal growth factor receptor (EGFR) are found in approximately 48% of Asian and 19% of Western patients with lung adenocarcinoma (LUAD), leading to aggressive tumor growth. While tyrosine kinase inhibitors (TKIs) like gefitinib and os

Externí odkaz: https://doaj.org/article/e5edff8536c445b9bec0eb00a9ed4bd5

Abstract 4287: The combination of statistical methods to compare observed and simulated data allowed to assess effectively the validity of mathematical model predictions in a context of a EGFR+ lung adenocarcinoma

Autor: Evgueni Jacob, Laura Villain, Nicoletta Ceres, Jean-Louis Palgen, Adele L'Hostis, Claudio Monteiro, Riad Kahoul

Publikováno v: Cancer Research. 83:4287-4287

Introduction In silico models proved to be a promising tool to complement and optimize clinical trials. These models should be validated to assess their capacity to reproduce real life behaviors. Opposed to real-life clinical trials where the amount

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ee9da0106a589d2242dc3918ba19a54
https://doi.org/10.1158/1538-7445.am2023-4287

Modelling the Response to Interleukin-7 Therapy in HIV-Infected Patients

Autor: Chloé Pasin, Daniel Commenges, Rodolphe Thiébaut, Laura Villain

Publikováno v: Mathematical, Computational and Experimental T Cell Immunology ISBN: 9783030572037

IL-7 is a cytokine produced by stromal cells in the thymus and bone marrow, epithelial cells and dendritic cells. This cytokine plays a key role in the T-cell homeostasis [17] and also for B- cell development. IL-7 promotes the survival, differentiat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3902d7abfbef23263e35721ff1add937
https://doi.org/10.1007/978-3-030-57204-4_6

Controlling IL-7 injections in HIV-infected patients

Autor: Rodolphe Thiébaut, Huilong Zhang, Chloé Pasin, Laura Villain, François Dufour

Publikováno v: Bulletin of Mathematical Biology
Bulletin of Mathematical Biology, Springer Verlag, 2018, ⟨10.1007/s11538-018-0465-8⟩
Bulletin of Mathematical Biology, 2018, ⟨10.1007/s11538-018-0465-8⟩
Bulletin of Mathematical Biology, Springer Verlag, 2018, 80 (9), pp.2349-2377. ⟨10.1007/s11538-018-0465-8⟩
Bulletin of Mathematical Biology, Springer Verlag, 2018

Immune interventions consisting in repeated injections are broadly used as they are thought to improve the quantity and the quality of the immune response. However, they also raise several questions that remain unanswered, in particular the number of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c249800c91265de0174b6e534bf38714
https://hal.inria.fr/hal-03063888

Associations between adverse childhood experiences and clinical characteristics of eating disorders

Autor: Eric Renard, Laura Villain, A. Ryst, Sébastien Guillaume, Maude Seneque, D. Hamroun, Patrick Lefebvre, Isabelle Jaussent, Laurent Maïmoun, P. Courtet

Publikováno v: Scientific Reports
Scientific Reports, 2016, 6 (1), pp.35761. ⟨10.1038/srep35761⟩
Scientific Reports, Nature Publishing Group, 2016, 6 (1), pp.35761. ⟨10.1038/srep35761⟩

Patients with eating disorders (EDs) frequently report a history of childhood trauma (CT). We investigated whether certain subtypes of CT are associated with more severe features of EDs, independently of psychiatric comorbidity, and whether they act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46f68e745bf53067b05cf7a37b27ef19
https://pubmed.ncbi.nlm.nih.gov/27804994