Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Laura V. Danai"'
Autor:
Adilson Guilherme, David J. Pedersen, Elizabeth Henchey, Felipe S. Henriques, Laura V. Danai, Yuefei Shen, Batuhan Yenilmez, DaeYoung Jung, Jason K. Kim, Irfan J. Lodhi, Clay F. Semenkovich, Michael P. Czech
Publikováno v:
Molecular Metabolism, Vol 6, Iss 8, Pp 781-796 (2017)
Background: The de novo biosynthesis of fatty acids (DNL) through fatty acid synthase (FASN) in adipocytes is exquisitely regulated by nutrients, hormones, fasting, and obesity in mice and humans. However, the functions of DNL in adipocyte biology an
Externí odkaz:
https://doaj.org/article/6bc9d2917df04eb3b86d55ef045f6e28
Autor:
Marina T. DiStefano, Rachel J. Roth Flach, Ozlem Senol-Cosar, Laura V. Danai, Joseph V. Virbasius, Sarah M. Nicoloro, Juerg Straubhaar, Sezin Dagdeviren, Martin Wabitsch, Olga T. Gupta, Jason K. Kim, Michael P. Czech
Publikováno v:
Molecular Metabolism, Vol 5, Iss 12, Pp 1149-1161 (2016)
Objective: Adipose tissue relies on lipid droplet (LD) proteins in its role as a lipid-storing endocrine organ that controls whole body metabolism. Hypoxia-inducible Gene 2 (Hig2) is a recently identified LD-associated protein in hepatocytes that pro
Externí odkaz:
https://doaj.org/article/da5c0d463454410a9f92bd4386dce998
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 8 (2018)
Cancers have an altered metabolism, and there is interest in understanding precisely how oncogenic transformation alters cellular metabolism and how these metabolic alterations can translate into therapeutic opportunities. Researchers are developing
Externí odkaz:
https://doaj.org/article/b5ca963773a244c99940fde8f23efd0e
Autor:
David J. Pedersen, Adilson Guilherme, Laura V. Danai, Lauren Heyda, Anouch Matevossian, Jessica Cohen, Sarah M. Nicoloro, Juerg Straubhaar, Hye Lim Noh, DaeYoung Jung, Jason K. Kim, Michael P. Czech
Publikováno v:
Molecular Metabolism, Vol 4, Iss 7, Pp 507-518 (2015)
Objective: Adipose tissue (AT) inflammation is associated with systemic insulin resistance and hyperinsulinemia in obese rodents and humans. A longstanding concept is that hyperinsulinemia may promote systemic insulin resistance through downregulatio
Externí odkaz:
https://doaj.org/article/25dbea29984f42b69a63ebc38311b475
Autor:
Laura V. Danai, Adilson Guilherme, Kalyani V. Guntur, Juerg Straubhaar, Sarah M. Nicoloro, Michael P. Czech
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 10, Pp 2697-2707 (2013)
Adipose tissue lipogenesis is paradoxically impaired in human obesity, promoting ectopic triglyceride (TG) deposition, lipotoxicity, and insulin resistance. We previously identified mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4), a
Externí odkaz:
https://doaj.org/article/673b1ac8792b4c8d87d275202345e5e4
Autor:
Sharanya Sivanand, Yetis Gultekin, Peter S. Winter, Sidney Y. Vermeulen, Konstantine Tchourine, Laura V. Danai, Brian T. Do, Kayla Crowder, Tenzin Kunchok, Allison N. Lau, Alicia M. Darnell, Satoru Morita, Dan G. Duda, Andrew Aguirre, Brian M. Wolpin, Caroline A. Lewis, Dennis Vitkup, Alex K. Shalek, Matthew G. Vander Heiden
Metastases arise from a subset of cancer cells that disseminate from the primary tumor; however, the factors that contribute to proliferation of cancer cells in a secondary site are incompletely understood. The ability of cancer cells to thrive in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35609d6038e328628d4549bfd6c98408
https://doi.org/10.1101/2022.08.17.504141
https://doi.org/10.1101/2022.08.17.504141
Autor:
David A. Tuveson, Nicholas J Matheson, Giulia Biffi, Evan C. Lien, Alicia M. Darnell, Laura V. Danai, Tyler Jacks, Shawn M. Davidson, Matthew G. Vander Heiden, Kiera M. Sapp, Ömer H. Yilmaz, Vasilena Gocheva, Sharanya Sivanand, Anna M. Westermark, Zhaoqi Li, Christopher R. Chin, Allison N. Lau, Raphael Ferreira, Jared R. Mayers
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
Funder: Jane Coffin Childs Memorial Fund for Medical Research; FundRef: http://dx.doi.org/10.13039/100001033
Funder: Swedish Foundation for Strategic Research; FundRef: http://dx.doi.org/10.13039/501100001729
Funder: Knut and Alice Wallenbe
Funder: Swedish Foundation for Strategic Research; FundRef: http://dx.doi.org/10.13039/501100001729
Funder: Knut and Alice Wallenbe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80fde3c5e548d66f8a3851a8ddc356cb
Autor:
Evan C. Lien, David A. Tuveson, Zhaoqi Li, Tyler Jacks, Allison N. Lau, Raphael Ferreira, Christopher R. Chin, Giulia Biffi, Alicia M. Darnell, Jared R. Mayers, Nicholas J Matheson, Matthew G. Vander Heiden, Laura V. Danai, Sharanya Sivanand, Ömer H. Yilmaz, Kiera M. Sapp, Vasilena Gocheva, Anna M. Westermark, Shawn M. Davidson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d1959975d018296b343c25c008cf167
https://doi.org/10.7554/elife.56782.sa2
https://doi.org/10.7554/elife.56782.sa2
Autor:
Allison N. Lau, Evan C. Lien, Laura V. Danai, Kiera M. Sapp, Ömer H. Yilmaz, Vasilena Gocheva, Matthew G. Vander Heiden, Shawn M. Davidson, Raphael Ferreira, Giulia Biffi, Alicia M. Darnell, Zhaoqi Li, Nicholas J Matheson, Anna M. Westermark, Sharanya Sivanand, Christopher R. Chin, David A. Tuveson, Tyler Jacks, Jared R. Mayers
Tumors are composed of many different cell types including cancer cells, fibroblasts, and immune cells. Dissecting functional metabolic differences between various cell types within a mixed population can be limited by the rapid turnover of metabolit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b9e0475fb71841d48fbb9cca2f5ebfd
Autor:
Camille X. Devoe, Talya L. Dayton, Allison N. Lau, Matthew G. Vander Heiden, Dolores Di Vizio, Alissandra L. Hillis, Laura V. Danai
Publikováno v:
Cancer & Metabolism, Vol 6, Iss 1, Pp 1-8 (2018)
BioMed Central
Cancer & Metabolism
BioMed Central
Cancer & Metabolism
Background While most cancer cells preferentially express the M2 isoform of the glycolytic enzyme pyruvate kinase (PKM2), PKM2 is dispensable for tumor development in several mouse cancer models. PKM2 is expressed in human pancreatic cancer, and ther