Výsledky vyhledávání - "Laura V Bownes"

Akademický článek

EZH2 inhibition decreases neuroblastoma proliferation and in vivo tumor growth.

Autor: Laura V Bownes, Adele P Williams, Raoud Marayati, Laura L Stafman, Hooper Markert, Colin H Quinn, Nikita Wadhwani, Jamie M Aye, Jerry E Stewart, Karina J Yoon, Elizabeth Mroczek-Musulman, Elizabeth A Beierle

Publikováno v: PLoS ONE, Vol 16, Iss 3, p e0246244 (2021)

Investigation of the mechanisms responsible for aggressive neuroblastoma and its poor prognosis is critical to identify novel therapeutic targets and improve survival. Enhancer of Zeste Homolog 2 (EZH2) is known to play a key role in supporting the m

Externí odkaz: https://doaj.org/article/00f6cc5570544d52be7e472249944929

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Akademický článek

Preclinical evidence for employing MEK inhibition in NRAS mutated pediatric gastroenteropancreatic neuroendocrine-like tumors

Autor: Colin H. Quinn, Andee M. Beierle, Adele P. Williams, Raoud Marayati, Laura V. Bownes, Hooper R. Market, Michael E. Erwin, Jamie M. Aye, Jerry E. Stewart, Elizabeth Mroczek-Musulman, Karina J. Yoon, Elizabeth A. Beierle

Publikováno v: Translational Oncology, Vol 47, Iss , Pp 102045- (2024)

Background: Pediatric gastroenteropancreatic neuroendocrine tumors are exceedingly rare, resulting in most pediatric treatment recommendations being based on data derived from adults. Trametinib is a kinase inhibitor that targets MEK1/2 and has been

Externí odkaz: https://doaj.org/article/0515712cdd0f4633a52a9cf06e81c2dc

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Akademický článek

PIM kinases mediate resistance to cisplatin chemotherapy in hepatoblastoma

Autor: Raoud Marayati, Laura L. Stafman, Adele P. Williams, Laura V. Bownes, Colin H. Quinn, Jamie M. Aye, Jerry E. Stewart, Karina J. Yoon, Joshua C. Anderson, Christopher D. Willey, Elizabeth A. Beierle

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

Abstract Despite increasing incidence, treatment for hepatoblastoma has not changed significantly over the past 20 years. Chemotherapeutic strategies continue to rely on cisplatin, as it remains the most active single agent against hepatoblastoma. Ho

Externí odkaz: https://doaj.org/article/651d99d3286c48f987b6b07498bbc8c8

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Akademický článek

Pleuropulmonary blastoma in an adolescent

Autor: Laura V. Bownes, Sara C. Hutchins, Agustin M. Cardenas, David R. Kelly, Elizabeth A. Beierle

Publikováno v: Journal of Pediatric Surgery Case Reports, Vol 59, Iss , Pp 101482- (2020)

Primary pulmonary malignancies are rare in childhood. The most common, pleuropulmonary blastoma (PPB), has an incidence of 25–50 cases per year in the United States (Knight and et al., 2019) [1]. The majority of children are diagnosed with PPB befo

Externí odkaz: https://doaj.org/article/ad956f502a734464845f104c51224d05

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Using 3D-bioprinted models to study pediatric neural crest-derived tumors

Autor: Colin H. Quinn, Andee M. Beierle, Janet R. Julson, Michael E. Erwin, Hasan Alrefai, Hooper R. Markert, Jerry E. Stewart, Sara Claire Hutchins, Laura V. Bownes, Jamie M. Aye, Elizabeth Mroczek-Musulman, Patricia H. Hicks, Karina J. Yoon, Christopher D. Willey, Elizabeth A. Beierle

Publikováno v: International Journal of Bioprinting.

The use of three-dimensional (3D) bioprinting has remained at the forefront of tissue engineering and has recently been employed for generating bioprinted solid tumors to be used as cancer models to test therapeutics. In pediatrics, neural crest-deri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df242bcbdd8b26f6dfa1d4e1aa77064c
https://doi.org/10.18063/ijb.723

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Rapid Characterization of Solid Tumors Using Resonant Sensors

Autor: Andee M. Beierle, Colin H. Quinn, Hooper R. Markert, Adam Carr, Raoud Marayati, Laura V. Bownes, Sara Claire Hutchins, Jerry E. Stewart, Benjamin Hill, Michael Ohlmeyer, Nigel F. Reuel, Elizabeth A. Beierle

Publikováno v: ACS omega. 7(36)

Cancer continues to be a significant cause of non-traumatic pediatric mortality. Diagnosis of pediatric solid tumors is paramount to prescribing the correct treatment regimen. Recent efforts have focused on non-invasive methods to obtain tumor tissue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bc678b9bc5aec627b3df74c04e5c325
https://pubmed.ncbi.nlm.nih.gov/36119978

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PIM3 kinase promotes tumor metastasis in hepatoblastoma by upregulating cell surface expression of chemokine receptor cxcr4

Autor: Raoud Marayati, Janet Julson, Laura V. Bownes, Colin H. Quinn, Laura L. Stafman, Andee M. Beierle, Hooper R. Markert, Sara C. Hutchins, Jerry E. Stewart, David K. Crossman, Anita B. Hjelmeland, Elizabeth Mroczek-Musulman, Elizabeth A. Beierle

Publikováno v: Clinicalexperimental metastasis. 39(6)

Patients presenting with metastatic hepatoblastoma have limited treatment options and survival rates as low as 25%. We previously demonstrated that Proviral Integration site in Maloney murine leukemia virus 3 (PIM3) kinase promotes tumorigenesis and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::037881ad2aea9d65f7f1729a83ea8a2d
https://pubmed.ncbi.nlm.nih.gov/36315303

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