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Encapsulation of Large-Size Plasmids in PLGA Nanoparticles for Gene Editing: Comparison of Three Different Synthesis Methods

Autor: Tresa López-Royo, Víctor Sebastián, Laura Moreno-Martínez, Laura Uson, Cristina Yus, Teresa Alejo, Pilar Zaragoza, Rosario Osta, Manuel Arruebo, Raquel Manzano

Publikováno v: Nanomaterials, Vol 11, Iss 10, p 2723 (2021)

The development of new gene-editing technologies has fostered the need for efficient and safe vectors capable of encapsulating large nucleic acids. In this work we evaluate the synthesis of large-size plasmid-loaded PLGA nanoparticles by double emuls

Externí odkaz: https://doaj.org/article/7280452fcab64166b47917b4fba12ee7

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In Cellulo Bioorthogonal Catalysis by Encapsulated AuPd Nanoalloys: Overcoming Intracellular Deactivation

Autor: Belén Rubio-Ruiz, Ana M. Pérez-López, Laura Uson, M. Carmen Ortega-Liebana, Teresa Valero, Manuel Arruebo, Jose L. Hueso, Victor Sebastian, Jesus Santamaria, Asier Unciti-Broceta

Publikováno v: Rubio Ruiz, B, Perez-Lopez, A, Uson, L, Ortega Liebana, M C, Valero, T, Arruebo, M, Hueso, J L, Sebastian, V, Santamaría, J & Unciti-Broceta, A 2023, ' In Cellulo Bioorthogonal Catalysis by Encapsulated AuPd Nanoalloys. Overcoming Intracellular Deactivation ', Nano Letters, vol. 23, no. 3, pp. 804-811 . https://doi.org/10.1021/acs.nanolett.2c03593

Bioorthogonal metallocatalysis has opened up a xenobiotic route to perform nonenzymatic catalytic transformations in living settings. Despite their promising features, most metals are deactivated inside cells by a myriad of reactive biomolecules, inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e31e38af801c3f6ddec213e6a08b54a
https://doi.org/10.1021/acs.nanolett.2c03593

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Optimization of superfluorinated PLGA nanoparticles for enhanced cell labelling and detection by

Autor: Cristina, Chirizzi, Lodovico, Gatti, María, Sancho-Albero, Victor, Sebastian, Manuel, Arruebo, Laura, Uson, Giulia, Neri, Jesus, Santamaria, Pierangelo, Metrangolo, Linda, Chaabane, Francesca, Baldelli Bombelli

Publikováno v: Colloids and surfaces. B, Biointerfaces. 220

Fluorine-19 (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::20249a1bea730aff454e5f7191a37405
https://pubmed.ncbi.nlm.nih.gov/36272281

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Novel intracellular antibiotic delivery system against Staphylococcus aureus: cloxacillin-loaded poly(d,l-lactide-co-glycolide) acid nanoparticles

Autor: Alicia Lacoma, José Domínguez, Beatriz Muriel-Moreno, Victor Sebastian, Laura Uson, Esther García-García, Gracia Mendoza, Manuel Arruebo, Cristina Prat

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Nanomedicine
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol

[Aim]: First, to compare in vitro minimum inhibitory concentrations (MIC) of free cloxacillin and cloxacillin-containing nanoparticles (NP) against methicillin-susceptible (MSSA) and resistant Staphylococcus aureus (MRSA) and second, to assess NP ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cddb1ce165f1547e1a5bf9ce6bdaee09
https://doi.org/10.2217/nnm-2019-0371

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Reversible stimuli-responsive nanomaterials with on-off switching ability for biomedical applications

Autor: Manuel Arruebo, Teresa Alejo, Laura Uson

Publikováno v: Journal of Controlled Release. 314:162-176

Many long-acting extended drug release systems can provide controlled or sustained release of therapeutic payloads. In the majority of those systems drug release cannot be stopped once it has started because they operate autonomously regardless of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e08d133e5d35bdbe65e4b1714bf5f3
https://doi.org/10.1016/j.jconrel.2019.10.036

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Nanogels with High Loading of Anesthetic Nanocrystals for Extended Duration of Sciatic Nerve Block

Autor: Martin Prieto, Manuel Arruebo, Ana Rodríguez-Largo, Victor Sebastian, Gracia Mendoza, Laura Uson, Guillermo Landa, Sara Garcia-Salinas, Silvia Irusta, Ricardo de Miguel, Cristina Yus Argon, Teresa Alejo

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

The development of thermoresponsive nanogels loaded with nanocrystals of the local anesthetic bupivacaine nanocrystals (BNCs) for prolonged peripheral nerve pain relief is reported here. BNCs were prepared using the antisolvent precipitation method f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ef6816074b76fc989e0721ec24aae2
https://pubmed.ncbi.nlm.nih.gov/33821601

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Encapsulation of Large-Size Plasmids in PLGA Nanoparticles for Gene Editing: Comparison of Three Different Synthesis Methods

Autor: Pilar Zaragoza, Tresa López-Royo, Rosario Osta, Victor Sebastian, Cristina Yus, Laura Moreno-Martínez, Manuel Arruebo, Teresa Alejo, Laura Uson, Raquel Manzano

Publikováno v: Nanomaterials
Volume 11
Issue 10
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Nanomaterials, Vol 11, Iss 2723, p 2723 (2021)
Digital.CSIC. Repositorio Institucional del CSIC

This article belongs to the Special Issue Functional Polymeric Nanoparticles.
The development of new gene-editing technologies has fostered the need for efficient and safe vectors capable of encapsulating large nucleic acids. In this work we eva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec0f8ac4d1422df85aea5379a35c12ed
http://zaguan.unizar.es/record/108510

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Nanoengineering Palladium Plasmonic Nanosheets Inside Polymer Nanospheres for Photothermal Therapy and Targeted Drug Delivery

Autor: Victor Sebastian, Teresa Alejo, Eric Leroy, Cristina Yus, Ane Larrea, Manuel Arruebo, Gracia Mendoza, Silvia Irusta, Raul Arenal, David García-Domingo, Laura Uson

Publikováno v: Advanced Functional Materials
Digital.CSIC. Repositorio Institucional del CSIC
instname

The incorporation of plasmonic nanoconstructs in biodegradable polymeric nanoparticles (NPs), together with therapeutic drugs in a controlled procedure is of interest for different applications in Nanomedicine. Advanced hybrid nanomaterials can be en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed1d88c9681bad92af263fa27f514b8d

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Insights into the mechanism of the formation of noble metal nanoparticles by: In situ NMR spectroscopy

Autor: José Miguel Mateo, Manuel Arruebo, Victor Sebastian, M. Victoria Gomez, Antonio de la Hoz, Laura Uson

Publikováno v: Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Digital.CSIC. Repositorio Institucional del CSIC
Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza

High-resolution solution Nuclear Magnetic Resonance (NMR) spectroscopy has been used to gain insights into the mechanism of the formation of gold, platinum and gold–platinum alloyed nanoparticles using metal precursors and tetrakis(hydroxymethyl)ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e3a22f752a2836d650d97d819b5200f
http://zaguan.unizar.es/record/96167

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