Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Laura Tsujikawa"'
Autor:
Kevin G McLure, Emily M Gesner, Laura Tsujikawa, Olesya A Kharenko, Sarah Attwell, Eric Campeau, Sylwia Wasiak, Adam Stein, Andre White, Eric Fontano, Robert K Suto, Norman C W Wong, Gregory S Wagner, Henrik C Hansen, Peter R Young
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83190 (2013)
Increased synthesis of Apolipoprotein A-I (ApoA-I) and HDL is believed to provide a new approach to treating atherosclerosis through the stimulation of reverse cholesterol transport. RVX-208 increases the production of ApoA-I in hepatocytes in vitro,
Externí odkaz:
https://doaj.org/article/e475fa058c6c480b97460e96177ac8f4
Autor:
Ewelina Kulikowski, Sylwia Wasiak, Laura Tsujikawa, Li Fu, Dean Gilham, Christopher Sarsons, Michael Sweeney, Jan Johansson
Publikováno v:
Journal of the American College of Cardiology. 81:559
Autor:
Laura Tsujikawa, Brooke Rakai, Li Fu, Kamyar Kalantar-Zadeh, Ravi Jahagirdar, Jan Johansson, Christopher Halliday, Christopher D. Sarsons, Sylwia Wasiak, Dean Gilham, Michael O. Sweeney, Norman C.W. Wong, Stephanie C. Stotz, Ewelina Kulikowski
Publikováno v:
Nephrology Dialysis Transplantation. 36
Background and Aims Major adverse cardiac events (MACE) remain a leading cause of mortality in chronic kidney disease (CKD). Apabetalone is an orally available inhibitor of bromodomain & extraterminal (BET) proteins – epigenetic readers that modula
Autor:
Laura Tsujikawa, Stephanie C. Stotz, Brooke Rakai, Sylwia Wasiak, Christopher D. Sarsons, Li Fu, Jan Johansson, Ewelina Kulikowski, Norman C.W. Wong, Michael O. Sweeney, Dean Gilham
Publikováno v:
Circulation. 142
Introduction: Apabetalone is an orally available small molecule that affects gene transcription by inhibiting BET protein interactions with acetylated histones and transcription factors. Apabetalone is in late stage clinical development for the treat
Autor:
Dean Gilham, Li Fu, Brooke D. Rakai, Laura Tsujikawa, Sylwia Wasiak, Stephanie Stotz, Christopher D. Sarsons, Norman C. Wong, Michael Sweeney, Jan O. Johansson, Kamyar KalantarZadeh, Ewelina Kulikowski
Publikováno v:
Journal of the American College of Cardiology. 79:286
Autor:
Christopher Halliday, Ravi Jahagirdar, Dean Gilham, Brooke Rakai, Laura Tsujikawa, Christopher D. Sarsons, Li Fu, Jan Johansson, Mathias Haarhaus, Phoebe Ho, Michael O. Sweeney, Kamyar Kalantar-Zadeh, Ewelina Kulikowski, Stephanie C. Stotz, Sylwia Wasiak, Kenith Lebioda, Norman C.W. Wong
Publikováno v:
Nephrology Dialysis Transplantation. 35
Background and Aims Elevated serum alkaline phosphatase (ALP) independently predicts major adverse cardiac events (MACE) by contributing to vascular calcification and endothelial dysfunction arising in chronic kidney disease (CKD) and cardiovascular
Autor:
Ewelina Kulikowski, Li Fu, Stephanie C. Stotz, Ravi Jahagirdar, Laura Tsujikawa, Sylwia Wasiak, Brooke Rakai, Jan O. Johansson, Norman C.W. Wong, Emily Daze, Dean Gilham, Michael O. Sweeney, Christopher Halliday
Publikováno v:
Cardiovascular Therapeutics
Cardiovascular Therapeutics, Vol 2020 (2020)
Cardiovascular Therapeutics, Vol 2020 (2020)
Chronic systemic inflammation contributes to cardiovascular disease (CVD) and correlates with the abundance of acute phase response (APR) proteins in the liver and plasma. Bromodomain and extraterminal (BET) proteins are epigenetic readers that regul
Autor:
Christopher Halliday, Richard Robson, Jan O. Johansson, Laura Tsujikawa, Kamyar Kalantar-Zadeh, Sylwia Wasiak, Ravi Jahagirdar, Norman C.W. Wong, Stephanie C. Stotz, Ewelina Kulikowski, Dean Gilham, Michael O. Sweeney
Publikováno v:
Kidney International Reports, Vol 3, Iss 3, Pp 711-721 (2018)
Kidney international reports, vol 3, iss 3
Kidney International Reports
Kidney international reports, vol 3, iss 3
Kidney International Reports
Introduction: Apabetalone, a small molecule inhibitor, targets epigenetic readers termed BET proteins that contribute to gene dysregulation in human disorders. Apabetalone has in vitro and in vivo anti-inflammatory and antiatherosclerotic properties.
Autor:
Eric Campeau, Sanjay Lakhotia, Laura Tsujikawa, Sarah Attwell, Olesya A. Kharenko, Reena G. Patel, Cyrus Calosing, Ravi Jahagirdar, Henrik C. Hansen
Publikováno v:
Cancer Research. 78:P3-06
More than 200,000 women are diagnosed with breast cancer every year in the United States. About 80% of these cases are estrogen receptor positive (ER+), which is characterized by the up-regulation of ER signaling and downstream activation of cyclin-d
Autor:
Christopher D. Sarsons, Ravi Jahargirdar, Laura Tsujikawa, Dean Gilham, Jan Johansson, Salman Azhar, Emily Daze, Sylwia Wasiak, Brooke Rakai, Norman C.W. Wong, Ewelina Kulikowski, Stephanie C. Stotz, Michael O. Sweeney
Publikováno v:
Journal of the American College of Cardiology. 77:1785
Introduction: Obesity increases the risk of type 2 diabetes (DM2) and cardiovascular disease (CVD), due to associated insulin resistance, dyslipidemia, high blood pressure and chronic inflammation....