Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Laura Trujillo Estrada"'
Autor:
Laura Cáceres Palomo, Juan García León, Laura Trujillo Estrada, Elba López Oliva, Javier Vitorica, Antonia Gutierrez
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S170- (2023)
Externí odkaz:
https://doaj.org/article/1285cd4ea93548d9ac93644d3a86fa69
Autor:
Clara Muñoz-Castro, Marina Mejias-Ortega, Elisabeth Sanchez-Mejias, Victoria Navarro, Laura Trujillo-Estrada, Sebastian Jimenez, Juan Antonio Garcia-Leon, Juan Jose Fernandez-Valenzuela, Maria Virtudes Sanchez-Mico, Carmen Romero-Molina, Ines Moreno-Gonzalez, David Baglietto-Vargas, Marisa Vizuete, Antonia Gutierrez, Javier Vitorica
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-21 (2023)
Abstract Microglia are brain-resident myeloid cells and play a major role in the innate immune responses of the CNS and the pathogenesis of Alzheimer's disease (AD). However, the contribution of nonparenchymal or brain-infiltrated myeloid cells to di
Externí odkaz:
https://doaj.org/article/4356ba8ee739486f92b38c01b92e57e2
Autor:
David Baglietto-Vargas, Stefania Forner, Lena Cai, Alessandra C. Martini, Laura Trujillo-Estrada, Vivek Swarup, Marie Minh Thu Nguyen, Kelly Do Huynh, Dominic I. Javonillo, Kristine Minh Tran, Jimmy Phan, Shan Jiang, Enikö A. Kramár, Cristina Nuñez-Diaz, Gabriela Balderrama-Gutierrez, Franklin Garcia, Jessica Childs, Carlos J. Rodriguez-Ortiz, Juan Antonio Garcia-Leon, Masashi Kitazawa, Mohammad Shahnawaz, Dina P. Matheos, Xinyi Ma, Celia Da Cunha, Ken C. Walls, Rahasson R. Ager, Claudio Soto, Antonia Gutierrez, Ines Moreno-Gonzalez, Ali Mortazavi, Andrea J. Tenner, Grant R. MacGregor, Marcelo Wood, Kim N. Green, Frank M. LaFerla
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Most instances of Alzheimer’s disease (AD) are sporadic or not associated with a particular mutation. Here, the authors develop knock-in mice that express wildtype human Aβ under control of the mouse App locus, which may have potential for modelli
Externí odkaz:
https://doaj.org/article/1e311a8bbdd34a96bb987b252f4dfaaf
Autor:
Raquel Sanchez-Varo, Elisabeth Sanchez-Mejias, Juan Jose Fernandez-Valenzuela, Vanessa De Castro, Marina Mejias-Ortega, Angela Gomez-Arboledas, Sebastian Jimenez, Maria Virtudes Sanchez-Mico, Laura Trujillo-Estrada, Ines Moreno-Gonzalez, David Baglietto-Vargas, Marisa Vizuete, Jose Carlos Davila, Javier Vitorica, Antonia Gutierrez
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder characterized by initial memory impairments that progress to dementia. In this sense, synaptic dysfunction and loss have been established as the pathological features that best co
Externí odkaz:
https://doaj.org/article/8efa1e12f990456da15d700c8c5ad782
Autor:
Raquel Sanchez-Varo, Marina Mejias-Ortega, Juan Jose Fernandez-Valenzuela, Cristina Nuñez-Diaz, Laura Caceres-Palomo, Laura Vegas-Gomez, Elisabeth Sanchez-Mejias, Laura Trujillo-Estrada, Juan Antonio Garcia-Leon, Ines Moreno-Gonzalez, Marisa Vizuete, Javier Vitorica, David Baglietto-Vargas, Antonia Gutierrez
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 10, p 5404 (2022)
Alzheimer’s disease (AD) constitutes the most prominent form of dementia among elderly individuals worldwide. Disease modeling using murine transgenic mice was first initiated thanks to the discovery of heritable mutations in amyloid precursor prot
Externí odkaz:
https://doaj.org/article/2fc137a7578741d99a3f0159b3e90e28
Autor:
Laura Trujillo-Estrada, Juan Antonio García-León, Javier Vitorica, Antonia Gutierrez, David Baglietto-Vargas, Frank M. LaFerla, Raquel Sanchez-Varo, Cristina Nuñez-Diaz, Elisabeth Sanchez-Mejias, Jose Carlos Davila, Ines Moreno-Gonzalez
Alzheimer’s disease (AD) is an incurable neurodegenerative disease affecting over 45 million people worldwide. Transgenic mouse models have made remarkable contributions toward clarifying the pathophysiological mechanisms behind the clinical manife
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ef533a5a7c17f06bcedb1e0cad2ba2
http://hdl.handle.net/10261/306226
http://hdl.handle.net/10261/306226
Autor:
Sebastià Parets, Marc Miralles, Maria A Fiol de‐Roque, Laura Trujillo‐Estrada, Joan Cabot, Mária Péter, Gábor Balogh, Paula Fernández‐García, Victoria Lladó, Xavier Busquets, Antonia Gutierrez, Pablo V. Escriba, Manuel Torres
Publikováno v:
Alzheimer's & Dementia. 17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c79e83c6545bf0849302f8d1a2e6525
https://doi.org/10.1002/alz.054514
https://doi.org/10.1002/alz.054514
Autor:
Celia da Cunha, David Baglietto-Vargas, Marie Minh Thu Nguyen, Laura Trujillo-Estrada, Stella T. Sarraf, Peter W. Vanderklish, Run Rong Kuang, Alessandra C. Martini, Stefania Forner, Simmon Vincent F, Dominic I. Javonillo, Frank M. LaFerla, Caroline T. Nguyen, Eric Huynh
Publikováno v:
Neurotherapeutics
Alzheimer’s disease (AD) is conceptualized as a synaptic failure disorder in which loss of glutamatergic synapses is a major driver of cognitive decline. Thus, novel therapeutic strategies aimed at regenerating synapses may represent a promising ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37d19815a73e58d983f287d324e850ed
https://pubmed.ncbi.nlm.nih.gov/34738197
https://pubmed.ncbi.nlm.nih.gov/34738197
Autor:
David Baglietto-Vargas, Alessandra C. Martini, Frank M. LaFerla, Stefânia Forner, Antonia Gutierrez, Laura Trujillo-Estrada, Angela Gomez-Arboledas
Publikováno v:
Current Alzheimer Research. 16:675-698
Astrocytes are key cells for adequate brain formation and regulation of cerebral blood flow as well as for the maintenance of neuronal metabolism, neurotransmitter synthesis and exocytosis, and synaptic transmission. Many of these functions are intri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::380d79678e13d1df857691ea4f7913c5
https://doi.org/10.2174/1567205016666190830110152
https://doi.org/10.2174/1567205016666190830110152
Autor:
Antonia Gutierrez, Rahasson R. Ager, Angela Gomez-Arboledas, Amanda McQuade, Carlos J. Rodriguez-Ortiz, Jose Carlos Davila, Jimmy Phan, Mathew Blurton-Jones, Stefania Forner, Celia da Cunha, Masashi Kitazawa, Laura Trujillo-Estrada, Melanie Tram, David Baglietto-Vargas, Alessandra C. Martini, Jordan-Vu Ha, Dominic I. Javonillo, Emma Danhash, Rodrigo Medeiros, Frank M. LaFerla
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance As we age, the innate immune system becomes dysregulated and is characterized by persistent inflammatory responses, and the chronic inflammation mediated by inflammatory receptors represents a key mechanism by which amyloid-beta (Aβ) dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f87777828c2e319720bda3dda102e595
http://europepmc.org/articles/PMC6800331
http://europepmc.org/articles/PMC6800331