Zobrazeno 1 - 10 of 23 pro vyhledávání: '"Laura Trotta"'
1
Akademický článek
Global analysis of dynamical decision-making models through local computation around the hidden saddle.
Autor: Laura Trotta, Eric Bullinger, Rodolphe Sepulchre
Publikováno v: PLoS ONE, Vol 7, Iss 3, p e33110 (2012)
Bistable dynamical switches are frequently encountered in mathematical modeling of biological systems because binary decisions are at the core of many cellular processes. Bistable switches present two stable steady-states, each of them corresponding
Externí odkaz: https://doaj.org/article/29e206d0f44a4d25a4c9b7b4ae2b29f2
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2
Akademický článek
Transcranial Magnetic Stimulation Studies in Alzheimer's Disease
Autor: Andrea Guerra, Federica Assenza, Federica Bressi, Federica Scrascia, Marco Del Duca, Francesca Ursini, Stefano Vollaro, Laura Trotta, Mario Tombini, Carmelo Chisari, Florinda Ferreri
Publikováno v: International Journal of Alzheimer's Disease, Vol 2011 (2011)
Although motor deficits affect patients with Alzheimer's disease (AD) only at later stages, recent studies demonstrated that primary motor cortex is precociously affected by neuronal degeneration. It is conceivable that neuronal loss is compensated b
Externí odkaz: https://doaj.org/article/a5dee922de834e7281f1b60b2c77c520
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3
Detection of Fraud in a Clinical Trial Using Unsupervised Statistical Monitoring
Autor: Hans-Juergen Lomp, Sylviane de Viron, Laura Trotta, Marc Buyse, Sebastiaan Höppner, Steve Young, Helmut Schumacher
Publikováno v: Therapeutic Innovation & Regulatory Science
Background A central statistical assessment of the quality of data collected in clinical trials can improve the quality and efficiency of sponsor oversight of clinical investigations. Material and Methods The database of a large randomized clinical t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30c88495b1e9f863004cc0de4435a2ac
https://doi.org/10.1007/s43441-021-00341-5
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4
Does Central Monitoring Lead to Higher Quality? An Analysis of Key Risk Indicator Outcomes
Autor: Sylviane de Viron, Laura Trotta, William Steijn, Steve Young, Marc Buyse
Publikováno v: Therapeutic innovationregulatory science.
Background Central monitoring, which typically includes the use of key risk indicators (KRIs), aims at improving the quality of clinical research by pro-actively identifying and remediating emerging issues in the conduct of a clinical trial that may
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2042a354430ac99977aa4f69ebdf4e7
https://pubmed.ncbi.nlm.nih.gov/36269551
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6
Detection of atypical data in multicenter clinical trials using unsupervised statistical monitoring
Autor: Junichi Sakamoto, Akira Tsuburaya, Lieven Desmet, Kazuhiro Yoshida, Marc Buyse, Satoshi Morita, Tomasz Burzykowski, Koji Oba, Laura Trotta, Yuusuke Kabeya, Paurush Praveen, David Venet, Erik Doffagne, Yumi Miyashita
Publikováno v: Clinical Trials. 16:512-522
Background/Aims A risk-based approach to clinical research may include a central statistical assessment of data quality. We investigated the operating characteristics of unsupervised statistical monitoring aimed at detecting atypical data in multicen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a89af287cdc26135165b10f244d314
https://doi.org/10.1177/1740774519862564
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7
Methods for detection of clusters of observations with an outlying correlation coefficient value
Autor: David Venet, Marc Buyse, Laura Trotta, Lieven Desmet, Tomasz Burzykowski
Multivariate datasets with a clustered structure are the natural framework for, e.g., multicentre clinical trials. We propose a number of methods aimed at detecting clusters with outlying correlation coefficients. While the methods can be used in a v
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::28acfe025b472b7aa52d3a85fb491bb5
https://doi.org/10.1101/2020.10.12.20211128
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8
Central statistical monitoring of investigator-led clinical trials in oncology
Autor: Marc Buyse, Laura Trotta, Everardo D. Saad, Junichi Sakamoto
Publikováno v: International Journal of Clinical Oncology
Investigator-led clinical trials are pragmatic trials that aim to investigate the benefits and harms of treatments in routine clinical practice. These much-needed trials represent the majority of all trials currently conducted. They are however threa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e920ee3e22e655d3d0e93e949591ed7d
https://pubmed.ncbi.nlm.nih.gov/32577951
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9
Akademický článek
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10
Functional Connectivity of Ventral and Dorsal Visual Streams in Posterior Cortical Atrophy
Autor: Aurélie Kas, Paolo Bartolomeo, Vincent Perlbarg, Cecile Gallea, Stéphane Lehéricy, Laura Trotta, Dalila Samri, Bruno Dubois, Agnès Michon, Raffaella Migliaccio, Lucette Lacomblez
Publikováno v: Journal of Alzheimer's Disease
Journal of Alzheimer's Disease, IOS Press, 2016, 51 (4), pp.1119-1130. ⟨10.3233/JAD-150934⟩
Journal of Alzheimer's Disease, 2016, 51 (4), pp.1119-1130. ⟨10.3233/JAD-150934⟩
International audience; Abstract: Background:Posterior cortical atrophy (PCA) induces progressive dysfunction of ventral and dorsal visual networks. Little is known, however, about corresponding changes in functional connectivity (FC). Objectives:To
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7169f275c1a0c17d0d40970a6612e945
https://doi.org/10.3233/jad-150934
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